Gịnị bụIhe ewepụtara Andrographis Paniculata ?
Andrographis paniculata, nke a makwaara dị ka "obi ụtọ otu ugboro" na "ahịhịa ilu", bụ osisi ahịhịa kwa afọ nke ezinụlọ Acanthaceae. Ọ bụ nke ndị South Asia dịka India na Sri Lanka, a na-ekesakwa ya nke ọma ugbu a n'ebe mmiri dị ọkụ na ebe ọkụ dị ka Guangdong na Fujian na China. Osisi ahụ dum na-atọ oke ilu, nwere ogwe osisi dị okirikiri, akwụkwọ dị iche iche, na oge okooko nke Ọgọst-Septemba. Ọgwụ ọdịnala nke ndị China na-eji mmetụta ya nke iwepụ okpomọkụ na iwepụ nsị, ime ka ọbara jụọ oyi na ibelata ọzịza iji gwọọ oyi, ahụ ọkụ, ọnyụnyụ ọbara, ọnya na ata agwọ. Ụlọ ọrụ ọgbara ọhụrụ na-ewepụta ihe ndị na-arụ ọrụ site na osisi na akwụkwọ site na mwepụ CO₂ dị oke mkpa na teknụzụ bio-enzymatic hydrolysis iji mepụta ntụ ntụ ọkọlọtọ nwere ọdịnaya andrographolide nke 8%-98%, na-akwalite nkwalite ya site na ọgwụ ahịhịa ndị mmadụ gaa na ihe eji emepụta ihe mba ụwa.
Isi ihe ndị dị mkpa nke ihe mejupụtaraAndrographis Paniculata Eihe ndị e ji ewepụta ihebụ ngwakọta lactone diterpenoid, nke nwere 2%-5%24, ọkachasị gụnyere:
1. Andrographolide:Usoro molekul C₂₀H₃₀O₅, nke ruru 30%-50%, bụ isi ihe na-arụ ọrụ maka nje bacteria na mgbochi mkpali.
2. Dehydroandrographolide:usoro molekul C₂₀H₂₈O₄, ebe agbaze 204℃, yana ọrụ mgbochi etuto dị ukwuu.
3. 14-Deoksiandrographolide:usoro molekul C₂₀H₃₀O₄, nke nwere arụmọrụ pụrụ iche megide leptospirosis.
4. Neoandrographolide:usoro molekul C₂₆H₄₀O₈, ezigbo mmiri na-agbaze, dị mma maka nkwadebe ọnụ.
Na mgbakwunye, flavonoids, phenolic acids na ihe ndị mejupụtara mmanụ na-agbanwe agbanwe na-eme ka ọrụ antioxidant na immunomodulatory dịkwuo mma.
Uru dị na yaIhe ewepụtara Andrographis Paniculata ?
1. Mgbochi Immunomodulation na Mgbochi Ọrịa
Ọgwụ nje na ọgwụ nje: Andrographolide nwere ihe karịrị 90% na Staphylococcus aureus na Shigella dysenteriae, arụmọrụ ya n'ịgwọ ọrịa bacillary yiri chloramphenicol. Mmiri ya nwere ike ibelata ọnụọgụgụ influenza site na 30% ma belata oge oyi site na 50%.
Mmezi Mgbochi Ahụ: Site n'ịrụ ọrụ macrophages na T lymphocytes, ọ nwere ike ịbawanye ọkwa nke CD4⁺ lymphocytes na ndị ọrịa HIV (data ahụike: 405→501/mm³, p=0.002).
2. Mgbochi Mgbochi Ọrịa Tumor na Angiogenesis
Ọgwụ mgbochi etuto ahụ kpọmkwem: Dehydroandrographolide nwere ike igbochi uto nke etuto W256 a gbanwere ma gbochie mmụba nke mkpụrụ ndụ kansa n'ụzọ dabere na dose.
Mgbochi ọrịa obi: Andrographolide na-egbochi ọrịa obi site na ibelata ngosipụta VEGFR2 ma na-egbochi ụzọ mgbaàmà ERK/p38, site na iji IC₅₀ nke 100-200μM.
3. Metabolism na Nchedo Akụkụ Ahụ
Nchedo imeju na mbelata abụba: Andrographolide na-ejigide ọkwa glutathione ma na-ebelata malondialdehyde (MDA) na ụdị mmerụ ahụ imeju carbon tetrachloride site na 40%, nke ka mma karịa silymarin.
Nchedo obi: Na-achịkwa nguzozi nitric oxide/endothelin, na-egbu oge atherosclerosis, ma na-ebelata ọkwa lipid dị n'ọbara na oke bekee nnwale.
4. Ọgwụ mgbochi mkpali na ọgwụ mgbochi oxidant
Mmiri e si n'osisi ahụ wepụta nwere ike kachasị sie ike iwepụ ihe ndị na-egbu egbu (IC₅₀=4.42μg/mL), nke dị irè okpukpu anọ karịa ihe ndị na-egbochi ọrịa sịntetik ma dịkwa mma maka ọrịa mkpali na-adịghị ala ala.
Kedu ihe bụ ngwa nkeIhe ewepụtara Andrographis Paniculata ?
1. Ọgwụ na Ọgwụgwọ Ahụike
Ọgwụ mgbochi nje: a na-eji ya maka ọrịa ọnya nje bacteria, ịgba ọgwụ n'ime akpa ume na nkwadebe ọnụ maka pharyngitis, yana ọgwụgwọ ahụike karịrị 85%.
Ọgwụ ndị a na-eji agwọ ọrịa kansa: "Andrographine" nke sitere na Andrographolide abanyela na nnwale ahụike nke Usoro nke Abụọ maka ọrịa leukemia na ọrịa kansa siri ike.
Nlekọta ọrịa na-adịghị ala ala: ọgwụgwọ mgbakwunye nke ọrịa retinopathy nke ọrịa shuga (0.5-2mg/kg/ụbọchị) na ọrịa ogbu na nkwonkwo (1-3mg/kg/ụbọchị).
2. Ịzụ Anụmanụ na Ịzụlite Akwụkwọ Ndụ
Ọgwụ nje ndị ọzọ: Ihe mgbakwunye nri Andrographis paniculata nke nwere ngwakọta na-ebelata afọ ọsịsa nke ezi ma mee ka ọnụego ndụ nke broilers dịkwuo elu; na-agbakwunye ihe ewepụtara 4% na nri carp, ọnụego mmụba ibu ruru 155.1%, a na-emezikwa ọnụego mgbanwe nri ka ọ bụrụ 1.11.
Mgbochi na njikwa ọrịa: Ọgwụ Andrographis paniculata na-agwọ ọrịa pneumonia na enteritis, na-agwọ ya ruo 90% na ọnụọgụ ọnwụ nke 10%.
3. Nri Ahụike na Kemịkalụ Kwa Ụbọchị
Nri bara uru:Andrographis paniculataihe e si na ya wepụtaA na-emepụta kapsụl (200mg kwa ụbọchị) n'ahịa ndị Europe na America maka ịchịkwa ahụ ike na mgbochi oyi.
Ngwa nlekọta akpụkpọ ahụ: Tinye ihe ndị na-egbochi mbufụt na ihe ndị na-eme ka anwụ ghara ịcha iji belata mmebi UV na ọbara ọbara nke akpụkpọ ahụ dị nro.
4. Ihe Ndị Ga-eme n'Ọgbọ Ndị Na-apụta
Ọgwụ ndị na-egbochi ọrịa obi: Mmepe nke nkwadebe ezubere maka etuto ahụ na ọrịa retinopathy nke ndị ọrịa mamịrị abụrụla isi ihe dị mkpa na bayoloji sịntetik.
Nlekọta Ahụike Anụ Ụlọ: A na-emepụta ihe mgbakwunye mgbochi mkpali na immunomodulatory maka nkịta na pusi na ahịa North America, na ọnụego uto kwa afọ nke 35%.
Maka ozi ndị ọzọ, biko kpọtụrụ:
Aha: Nora
Ekwentị/WhatsApp: +86 15594821525
Email:nora@lfherb.com
Oge ozi: Ọktoba-20-2026