I-Tauroursodeoxycholic Acid (I-TUDCA), njengokuphuma kwe-bile acid yemvelo, sekugxilwe embonini yezempilo yomhlaba wonke eminyakeni yamuva nje ngenxa yokuvikela isibindi okubalulekile kanye nemiphumela ye-neuroprotection. Ngo-2023, usayizi wemakethe ye-TUDCA yomhlaba wonke udlule ezigidini ezingama-US $350, futhi kulindeleke ukuthi ufinyelele ezigidini ezingama-US $820 ngo-2030, ngenani lokukhula elihlanganisiwe lonyaka lika-12.8%. Izimakethe zaseYurophu nezaseMelika zibuswa izinga eliphezulu lokungena kwemikhiqizo yezempilo. Isifunda sase-Asia-Pacific (ikakhulukazi i-China ne-India) sihamba phambili emhlabeni ngezinga lokukhula njengoba ukwanda kwezifo zesibindi ezingapheli kanye nokusetshenziswa kwezempilo kuthuthukiswa.
Ngaphandle kwalokho, ngokwamalungelo obunikazi aphethwe yi-Besty Pharmaceuticals, i-TUDCA ingathuthukisa kakhulu inqubo ye-pathological yezifo ezihlukahlukene ze-neurodeergenerative ngokuvimbela i-apoptosis ye-neuronal kanye nokunciphisa ingcindezi ye-oxidative. Ukwengeza, ukusetshenziswa okujulile kobuchwepheshe be-AI ocwaningweni nasekuthuthukisweni kwezidakamizwa (njengokuhlolwa okuhlosiwe kanye nokwenza ngcono izivivinyo zomtholampilo) kusheshise ukusebenza kahle kokuguqulwa komtholampilo kwe-TUDCA, futhi usayizi wemakethe ofanele kulindeleke ukuthi udlule u-US$1 bhiliyoni eminyakeni emihlanu ezayo.
●Indlela yokulungiselela: ukusuka ekukhishweni kwendabuko kuya ekuhlanganiseni okuluhlaza
1. Indlela Yendabuko Yokukhipha:I-ursodeoxycholic acid (UDCA) ihlukaniswa ne-bile bile, bese ihlanganiswa ne-taurine ukukhiqiza.I-TUDCA. Inqunyelwe izimiso zokuziphatha zokuvikela izilwane kanye namandla okukhiqiza, izindleko ziphezulu futhi zishintshwa kancane kancane.
2. Indlela Yokwenziwa Kwamakhemikhali:Isebenzisa i-bile acid njengempahla eluhlaza, i-UDCA ihlanganiswa nge-oxidation, ukunciphisa, ukufingqa nezinye izinyathelo, bese i-taurized. Ukuhlanzeka kungafinyelela ngaphezu kwama-99%, kodwa inqubo iyinkimbinkimbi futhi ukungcola kukhulu.
3. I-Microbial Fermentation Method (I-Frontier Direction):Ukusebenzisa i-Escherichia coli eyenziwe ngofuzo noma imvubelo ukuze kuhlanganiswe ngokuqondileI-TUDCA, inezinzuzo ze-green, low-carbon kanye namandla amakhulu okukhiqiza ngobuningi. Ngo-2023, Inkampani ye-BioCore eNingizimu Korea izuze ukukhiqizwa kokuhlola, yehlisa izindleko ngama-40%.
4. Indlela ye-Enzyme Catalysis:Ubuchwepheshe be-enzyme engakwazi ukuhamba bungakwazi ukugqugquzela ngempumelelo inhlanganisela ye-UDCA ne-taurine, futhi izimo zokusabela zithambile, ezifanele ukukhiqizwa kwebanga lezemithi.
●Izinzuzo: Indlela yokusebenza okuhloswe ngayo okuningi, ehlanganisa izindawo eziningi zezifo
Indlela ewumgogodla ye-TUDCA ukusimamisa ulwelwesi lweseli, ukuvimbela ukucindezelwa kwe-endoplasmic reticulum kanye nezindlela zokusayina ze-apoptosis, futhi kuqinisekiswe ngokomtholampilo ezimweni eziningi:
1. Izifo ze-Hepatobiliary:
⩥ Ukwelashwa kwe-primary biliary cholangitis (PBC), isifo sesibindi esinamafutha angenalo utshwala (NAFLD), nokunciphisa izinkomba ze-ALT/AST.
⩥ Yehlisa i-cholestasis futhi ikhuthaze i-bilirubin metabolism. I-FDA igunyaze isimo sayo somuthi wezintandane.
2. I-Neuroprotection:
⩥ Thuthukisa ukulimala kwe-neuronal ku-Alzheimer's disease kanye nesifo sika-Parkinson. Ucwaningo lwezemvelo lwango-2022 lubonise ukuthi lungehlisa i-β-amyloid deposition.
⩥ Ibonise amandla okubambezela inkambo yesifo ezivivinyweni zomtholampilo ze-amyotrophic lateral sclerosis (ALS).
3. I-Metabolism kanye Ne-Anti-Aging:
⩥ Lawula ukuzwela kwe-insulin futhi usize ekulawuleni isifo sikashukela.
⩥ Yenza kusebenze umsebenzi we-mitochondrial, welule isikhathi sokuphila sezinto eziphilayo eziyimodeli, futhi ube isithako sekhandidethi "sezidakamizwa zokuphila isikhathi eside".
4. Izicelo Ze-Ophthalmic:
⩥ Inomphumela ovikelayo ku-retinitis pigmentosa kanye ne-glaucoma, futhi amaconsi esweni ahlobene angenile ezivivinyweni zomtholampilo zeSigaba sesi-III.
●I-TUDCA izindawo zokufaka isicelo: kusuka emithini kuya ekudleni okusebenzayo
1. Inkambu yezokwelapha:
⩥ Imithi kadokotela: I-TUDCA esetshenziselwa i-PBC, ukuchithwa kwe-gallstone (njengamalungiselelo e-European Taurursodiol).
⩥ Ukuthuthukiswa kwezidakamizwa zezintandane: ukwelashwa okuhlangene kwezifo ezingavamile njenge-spinal muscular atrophy (SMA).
2. Imikhiqizo Yezempilo:
⩥ Amaphilisi okuvikela isibindi, imikhiqizo ye-hangover: TUDCAkungasetshenziswange-silymarin ne-curcumin ukuthuthukisa umphumela.
⩥ Amaphilisi e-anti-aging: ahlanganiswe ne-NMN ne-resveratrol, egxile ekulungiseni i-mitochondrial.
3. Ukondleka Kwezemidlalo:
⩥ Ukunciphisa ukuvuvukala kwemisipha ngemva kokuqeqeshwa okunamandla, okusetshenziswe njengesengezo sokutakula ngabadlali abaqeqeshiwe.
4. Impilo Yezilwane Ezifuywayo:
⩥ Ukwelashwa nokunakekelwa kwezempilo kwezifo zesibindi ne-gallbladder ezinjeni nasemakati, imikhiqizo ehlobene emakethe yase-US izokhula ngama-35% ngo-2023.
Ngokukhula kwesibalo sabantu abaguga kanye nezinga eliphezulu lezifo ze-metabolic, inani le-TUDCA emikhakheni yezokwelapha, ukunakekelwa kwezempilo, kanye nokulwa nokuguga lizophinde likhishwe. Ubuchwepheshe bebhayoloji yokwenziwa bungase bukhuthaze izintengo ezithengekayo futhi buvule imakethe yezempilo ebiza amakhulu ezigidigidi zama-yuan.
●NewGREEN SupplyI-TUDCAImpushana
Isikhathi sokuthumela: Apr-15-2025
