I-Gymnema Sylvestre Extract: Impumelelo yokuqondisa izigwegwe kusukela kukhambi lendabuko le-hypoglycemic kuya kunkanyezi entsha ekuvikelweni kwemizwa

●Yini? I-Gymnema Sylvestre Extract?

I-Gymnema sylvestre iwumvini womndeni wakwa-Apocynaceae, usatshalaliswa kabanzi ezindaweni ezishisayo njenge-Guangxi kanye ne-Yunnan e-China. Ukusetshenziswa kokwelapha kwendabuko kugxile kakhulu emaqabunga awo, asetshenziselwa ukwehlisa ushukela wegazi, ukuvimbela ukubola kwamazinyo kanye nokuvimbela ukusabela kokunambitheka okumnandi. Kodwa-ke, ucwaningo lwamuva luye lwathola ukuthi imithombo yayo ye-stem nayo inothile ngezithako ezisebenzayo, futhi izinqolobane ziphindwe izikhathi ezingaphezu kwe-10 kunamaqabunga. Ngokusebenzisa indlela ehlelekile yokuhlukanisa i-solvent, i-n-butanol kanye nezingxenye ze-ethanol ezingu-95% ze-stem extracts zibonise izici ezifanayo ze-UV spectra kanye nezici ze-chromatography zongqimba oluncane emaqabunga, okubonisa ukuthi izithako ezisebenzayo zalezi zimbili ziyavumelana kakhulu. Lokhu kutholwa kunikeza ukwesekwa okubalulekile ekwandiseni imithombo yezidakamizwa nokunciphisa izindleko zokuthuthukisa.

Ukwakheka kwamakhemikhali weI-Gymnema Sylvestre khiphaiyinkimbinkimbi futhi ihlukahlukene, ikakhulukazi okuhlanganisa:

Ama-Cyclols nama-steroids:I-Conduritol A, njengengxenye eyinhloko ye-hypoglycemic, ingakhuthaza ukuhlanganiswa kwe-glycogen; I-stigmasterol kanye ne-glucoside yayo inemiphumela yokulawula eqeda ukuvuvukala;

I-Saponin compounds:Ngo-2020, ama-saponins amasha ayisishiyagalombili e-C21 steroidal saponins (gymsylvestrosides AH) ahlukaniswa okokuqala, futhi izakhiwo zawo ziqukethe i-glucuronic acid namayunithi e-rhamnose, okuwanika umsebenzi oyingqayizivele wezinto eziphilayo;

Izingxenye ze-Synergistic:ama-alkanol amaketanga amade afana ne-lupine cinnamyl ester kanye ne-n-heptadecanol athuthukisa umthamo we-antioxidant ngokukhipha ama-radicals mahhala.

Kuyaphawuleka ukuthi ukuhlanzeka kwe-stem saponins kungafinyelela ngaphezu kwe-90%, futhi ukuhlanzwa okukhulu kungafinyelelwa ngobuchwepheshe be-ethanol recrystallization, ukugwema ukusetshenziswa kwezinyibiliki ezinobuthi ezifana ne-chloroform.

●ZiyiniIzinzuzoKwe I-Gymnema Sylvestre Extract?

1. Ukuphathwa Kwesifo Sikashukela

Ucwaningo lwe-Pharmacological lubonise ukuthi ukukhishwa kwe-stem ethanol kunganciphisa izinga likashukela egazini ngo-30% -40% kumagundane e-alloxan Diabetesic, futhi indlela yokusebenza ibonisa ukusebenzisana kwezindlela eziningi:

Ukuvikelwa kwe-Islet: lungisa amaseli e-β alimele futhi andise ukukhiqizwa kwe-insulin;

Ukulawulwa kwe-glucose metabolism: khuthaza ukuhlanganiswa kwe-glycogen yesibindi futhi uvimbele umsebenzi we-α-glucosidase wamathumbu (nakuba izinga lokuvinjelwa kwe-monomer saponin lingu-4.9% -9.5% kuphela, umphumela we-synergistic we-extract yonke ubalulekile);

Ukungenelela kokucindezeleka kwe-oxidative: nciphisa amazinga e-lipid peroxide futhi ukwandise umsebenzi we-superoxide dismutase.

2. I-Neuroprotection

Ucwaningo olwanyatheliswa ku-Scientific Reports ngo-2025 lwembula amandlaI-Gymnema Sylvestrekhiphaekwelapheni isifo i-Alzheimer's (AD):

Ukukhomba amaprotheni angukhiye e-AD: ama-metabolites i-S-adenosylmethionine kanye ne-bamipine anokusondelana okuphezulu okubophayo ne-β-secretase (BACE1) kanye ne-monoamine oxidase B (MAO-B), ehlisa ukubekelwa phansi kwe-β-amyloid;

Ukulawulwa kwe-Neural pathway: ngokuvula indlela yokubonisa i-cAMP/PI3K-Akt, ukwandisa inkulumo ye-choline acetyltransferase (Chat), kuyilapho kunciphisa umsebenzi we-acetylcholinesterase, nokuthuthukisa ukudluliswa kwe-synaptic;

Ukuqinisekiswa kokuhlolwa kweseli: Kumodeli yeseli ye-neural eyenziwe ye-Aβ42, okukhishiwe kunciphise ukukhiqizwa kwezinhlobo ze-oxygen esebenzayo (ROS) ngo-40% kanye nezinga le-apoptosis ngaphezu kuka-50%.

● ZiyiniIsiceloOf I-Gymnema Sylvestre Extract ?

Ukuthuthukiswa kwemithi: I-Guangxi Guilin Jiqi Inkampani isebenzise ama-saponins aphelele e-Gymnema sylvestre (ubumsulwa 98.2%) ukuze kuthuthukiswe amalungiselelo esifo sikashukela1; ithimba labacwaningi baseNdiya liqhubekisela phambili izivivinyo zangaphambi komtholampilo ze-neuroprotective extracts;

Ukudla okunempilo: ama-extracts amaqabunga asetshenziswa njengama-sweetness inhibitors emvelo ekudleni okungenashukela; i-stem ethanol extracts ithuthukiswa njengeziphuzo ezisebenzayo zokulawula ushukela wegazi;

Izicelo zezolimo: Izingxenye ezingahlanzekile ezingahlanzekile zisetshenziswa njengezibulala-zinambuzane ezisekelwe esitshalweni, eziqondiswe ohlelweni lwezinzwa lwama-arthropods futhi zinezakhiwo eziwohlokayo.

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