●Gịnị bụ Gymnema Sylvestre wepụ?
Gymnema sylvestre bụ osisi vine nke ezinụlọ Apocynaceae, na-ekesa n'ọtụtụ ebe na mpaghara okpomọkụ dị ka Guangxi na Yunnan na China. Ojiji ọgwụ ọdịnala na-elekwasị anya na akwụkwọ ya, nke a na-eji belata shuga ọbara, gbochie ire eze ma gbochie mmeghachi omume ụtọ ụtọ. Otú ọ dị, nnyocha e mere n'oge na-adịbeghị anya achọpụtala na ihe ndị e ji eme ihe na-emepụta ihe na-emepụta ihe na-arụ ọrụ, na ihe ndị dị n'ime ya karịrị okpukpu iri karịa akwụkwọ. Site na usoro nkewa ihe mgbaze na-ahazi, n-butanol na 95% ethanol akụkụ nke ihe ndị na-emepụta ihe na-egosi ụdị chromatography UV yiri nke ahụ na akwụkwọ ahụ, na-egosi na ihe ndị na-arụ ọrụ nke abụọ na-agbanwe agbanwe. Nchọpụta a na-enye nkwado dị mkpa maka ịgbasa isi iyi ọgwụ yana ibelata ọnụ ahịa mmepe.
The chemical mejupụtara nkeGymnema sylvestre wepụdị mgbagwoju anya ma dị iche iche, ọkachasị gụnyere:
Cyclols na steroid:Conduritol A, dị ka isi akụrụngwa hypoglycemic, nwere ike ịkwalite njikọ glycogen; stigmasterol na glucoside ya nwere mmetụta nchịkwa mgbochi mkpali;
Ngwakọta nke saponin:Na 2020, asatọ ọhụrụ C21 steroidal saponins (gymsylvestrosides AH) kewapụrụ na nke mbụ, na ihe owuwu ha nwere glucuronic acid na rhamnose nkeji, na-enye ha ọrụ ndu pụrụ iche;
Ngwakọta mmekọrịta:Alkanol ndị nwere ogologo agbụ dị ka lupine cinnamyl ester na n-heptadecanol na-akwalite ikike antioxidant site n'ịchụpụ radicals efu.
Ọ dị mma ịmara na ịdị ọcha nke saponins stem nwere ike iru karịa 90%, enwere ike nweta ịdị ọcha dị ukwuu site na teknụzụ ethanol recrystallization, na-ezere iji ihe mgbaze na-egbu egbu dị ka chloroform.
●Kedu ihe bụUruNke Gymnema Sylvestre wepụ?
1. Nlekọta ọrịa shuga
Ọmụmụ ọgwụ egosila na mwepu ethanol nwere ike ibelata ọkwa shuga ọbara site na 30% -40% na oke oke ndị na-arịa ọrịa shuga alloxan, na usoro nke ime ihe na-egosi mmekọrịta nke ọtụtụ ụzọ:
Nchedo agwaetiti: rụkwaa mkpụrụ ndụ β mebiri emebi ma na-abawanye mmepụta insulin;
Usoro metabolism nke glucose: na-akwalite njikọ glycogen imeju ma na-egbochi ọrụ α-glucosidase intestinal (ọ bụ ezie na ọnụ ọgụgụ mgbochi nke monomer saponin bụ naanị 4.9% -9.5%, mmetụta synergistic nke nchịkọta dum dị ịrịba ama);
Ntinye aka nke nrụgide Oxidative: belata ọkwa lipid peroxide wee bulie ọrụ superoxide dismutase.
2. Neuroprotection
Nnyocha e bipụtara na Scientific Reports na 2025 kpughere ikike nkeGymnema sylvestrewepụna ọgwụgwọ ọrịa Alzheimer (AD):
Ezubere iche protein protein AD isi: metabolites S-adenosylmethionine na bamipine nwere njikọ chiri anya na β-secretase (BACE1) na monoamine oxidase B (MAO-B), na-ebelata ntinye β-amyloid;
Usoro usoro akwara ozi: site n'ịkwalite ụzọ akara cAMP / PI3K-Akt, na-abawanye okwu choline acetyltransferase (Chat), na-ebelata ọrụ acetylcholinesterase, na ịkwalite nnyefe synaptic;
Nnwale nnwale cell: N'ime ụdị mkpụrụ ndụ akwara Aβ42 butere, mpụta ahụ belatara ọgbọ nke ụdị oxygen na-emeghachi omume (ROS) site na 40% yana ọnụego apoptosis karịa 50%.
● Kedu ihe bụNgwaOf Gymnema Sylvestre wepụ ?
Mmepe ọgwụ: Guangxi Guilin Jiqi Company ejirila saponins nke Gymnema sylvestre (dị ọcha 98.2%) maka mmepe nke nkwadebe ọrịa shuga1; ndị otu nyocha nke India na-aga n'ihu na-aga n'ihu ule preclinical nke mpụta neuroprotective ya;
Nri dị mma: a na-eji mpempe akwụkwọ eme ihe dị ka ihe na-egbochi uto anụ ahụ maka nri na-enweghị shuga; a na-emepụta ihe na-emepụta ethanol stem dị ka ihe ọṅụṅụ na-arụ ọrụ maka ịhazi shuga ọbara;
Ngwa ọrụ ugbo: a na-eji ihe ndị na-emepụta ihe na-adịghị ọcha na-eme ihe dị ka ihe ọkụkụ sitere na ụmụ ahụhụ, na-elekwasị anya na usoro ụjọ nke arthropods na inwe ihe ndị na-emebi emebi.
lỌdịmma dị elu NEWGREENGymnema Sylvestre wepụNtụ ntụ
Oge nzipu: Jul-21-2025
