Tauroursodeoxycholic Acid (I-TUDCA), njenge-derivative ye-asidi ye-bile yendalo, iye yaba yingqwalasela yoshishino lwezempilo lwehlabathi kwiminyaka yamuva nje ngenxa yokukhusela isibindi kunye nemiphumo ye-neuroprotection. Ngo-2023, ubungakanani bemakethi ye-TUDCA yehlabathi jikelele idlule kwi-US $ 350 yezigidi, kwaye kulindeleke ukuba ifike kwi-US $ 820 yezigidi ngo-2030, kunye nezinga lokukhula lonyaka elihlanganisiweyo ye-12.8%. Iimarike zaseYurophu naseMelika zilawulwa lizinga eliphezulu lokungena kweemveliso zempilo. Ummandla wase-Asia-Pacific (ingakumbi i-China kunye ne-Indiya) ukhokela ihlabathi ngesantya sokukhula njengoko iziganeko zesifo sesibindi esingapheliyo sanda kunye nokuphuculwa kokusetyenziswa kwempilo.
Ngaphandle koko, ngokwamalungelo awodwa omenzi wechiza aphethwe yi-Besty Pharmaceuticals, i-TUDCA inokuphucula kakhulu inkqubo ye-pathological yezifo ezahlukeneyo ze-neurodeergenerative ngokuthintela i-neuronal apoptosis kunye nokunciphisa uxinzelelo lwe-oxidative. Ukongeza, ukusetyenziswa okunzulu kwethekhnoloji ye-AI kuphando lweziyobisi kunye nophuhliso (njengokujongwa okujoliswe kuko kunye nokulungiswa kovavanyo lweklinikhi) kukhawulezise ukusebenza kwenguqu yeklinikhi ye-TUDCA, kwaye ubungakanani bentengiso obufanelekileyo kulindeleke ukuba budlule kwi-1 yeebhiliyoni zeedola kwiminyaka emihlanu ezayo.
●Indlela yokulungiselela: ukusuka kwi-extraction yendabuko ukuya kwi-green synthesis
1. Indlela yesiNtu yokutsalwa:I-ursodeoxycholic acid (UDCA) yohlulwe kwinyongo yebhere, kwaye emva koko idityaniswe ne-taurine ukuvelisa.I-TUDCA. Ilinganiselwe ngokuziphatha kokhuseleko lwezilwanyana kunye nomthamo wemveliso, ixabiso liphezulu kwaye ngokuthe ngcembe litshintshwa.
2. Indlela yokuDityaniswa kwemichiza:Ukusebenzisa i-bile acid njengento ekrwada, i-UDCA yenziwe nge-oxidation, ukunciphisa, ukudibanisa kunye namanye amanyathelo, emva koko i-taurized. Ubunyulu bunokufikelela ngaphezu kwe-99%, kodwa inkqubo inzima kwaye ungcoliseko lukhulu.
3. Indlela yeMicrobial Fermentation (Ulwalathiso lwangaphambili):Ukusebenzisa i-Escherichia coli eyenziwe ngofuzo okanye igwele ukudibanisa ngqoI-TUDCA, ineenzuzo zohlaza, i-low-carbon kunye nemveliso enkulu yokuvelisa. Kwi-2023, iNkampani ye-BioCore eMzantsi Korea iphumelele imveliso yokulinga, ukunciphisa iindleko nge-40%.
4. Indlela ye-Enzyme Catalysis:Itekhnoloji ye-enzyme engenakunyakaziswa inokwenza ngokufanelekileyo ukudityaniswa kwe-UDCA kunye ne-taurine, kwaye iimeko zokusabela zithambile, ezifanelekileyo kwimveliso yodidi lwamayeza.
●Iinzuzo: Indlela yokwenza izinto ekujoliswe kuzo ezininzi, ezibandakanya uluhlu olubanzi lwemimandla yezifo
Indlela engundoqo ye-TUDCA kukuzinzisa i-membrane yeseli, inqanda uxinzelelo lwe-endoplasmic reticulum kunye neendlela zokubonisa i-apoptosis, kwaye iqinisekisiwe ngokweklinikhi kwiimeko ezininzi:
1. Izifo zeHepatobiliary:
⩥ Unyango lwe-primary biliary cholangitis (PBC), isifo sesibindi esingenalo utywala (NAFLD), kunye nokunciphisa izibonakaliso ze-ALT / AST.
⩥ Ukunciphisa i-cholestasis kunye nokukhuthaza i-bilirubin metabolism. I-FDA ivume ubume bayo beziyobisi eziyinkedama.
2. Ukhuseleko lwemithambo-luvo:
⩥ Ukuphucula umonakalo we-neuronal kwi-Alzheimer's disease kunye nesifo sika-Parkinson. Uphononongo lweNdalo luka-2022 lubonise ukuba inokunciphisa i-β-amyloid deposition.
⩥ Ibonise amandla okulibazisa ikhosi yesifo kulingo lwezonyango lwe-amyotrophic lateral sclerosis (ALS).
3. I-Metabolism kunye nokuchasana nokuguga:
⩥ Ukulawula ubuntununtunu kwi-insulin kwaye uncedise ekulawuleni isifo seswekile.
⩥ Yenza kusebenze umsebenzi we-mitochondrial, wandise ubomi bemodeli yezinto eziphilayo, kwaye ube sisithako somgqatswa "samachiza obomi obude".
4. Ukusetyenziswa kwamehlo:
⩥ Inefuthe elikhuselayo kwi-retinitis pigmentosa kunye neglaucoma, kwaye amathontsi eliso anxulumeneyo aye angena kwiSigaba sesi-III solingo lwezonyango.
●I-TUDCA indawo yesicelo: ukusuka kwiyeza ukuya kukutya okusebenzayo
1. Indawo yezoNyango:
⩥ Amachiza amiselweyo: I-TUDCA esetyenziselwa i-PBC, i-gallstone dissolution (njengamalungiselelo eTaurursodiol yaseYurophu).
⩥ Ukuphuhliswa kweziyobisi zeenkedama: unyango oludibeneyo lwezifo ezinqabileyo ezifana ne-spinal muscular atrophy (SMA).
2. Iimveliso zempilo:
⩥ Iipilisi zokukhusela isibindi, iimveliso ze-hangover: TUDCAingasetyenziswakunye ne-silymarin kunye ne-curcumin ukuphucula umphumo.
⩥ Ii-capsules zokuguga: zixutywe kunye ne-NMN kunye ne-resveratrol, egxininisa ukulungiswa kwe-mitochondrial.
3. Isondlo sezemidlalo:
⩥ Ukunciphisa ukuvuvukala kwemisipha emva koqeqesho oluphezulu, olusetyenziswa njengesongezelelo sokubuyisela ngabadlali beengcali.
4. Impilo Yezilwanyana Zasekhaya:
⩥ Unyango kunye nokhathalelo lwempilo lwezifo zesibindi kunye ne-gallbladder kwizinja kunye neekati, iimveliso ezinxulumeneyo kwimarike yase-US ziya kukhula ngama-35% ngo-2023.
Ngokunyuka kwabantu abaguga kunye neziganeko eziphezulu zezifo ze-metabolic, ixabiso le-TUDCA kwiinkalo zamayeza, ukhathalelo lwempilo, kunye nokuchasana nokuguga kuya kukhutshwa ngakumbi. Itekhnoloji yokwenziwa kwebhayoloji inokukhuthaza amaxabiso afikelelekayo kwaye ivule imarike yezempilo exabisa amakhulu eebhiliyoni zeeyuan.
● Unikezelo ENTSHAI-TUDCAUmgubo
Ixesha lokuposa: Apr-15-2025
