I-Gymnema Sylvestre Extract: Impumelelo yoluleko ukusuka kwimifuno yendabuko ye-hypoglycemic ukuya kwinkwenkwezi entsha kukhuseleko lwe-neuroprotection.

●Yintoni i Gymnema Sylvestre Extract?

IGymnema sylvestre ngumdiliya wosapho lwe-Apocynaceae, isasazwe ngokubanzi kwindawo eziphantsi kweTropiki ezifana neGuangxi kunye neYunnan eChina. Amayeza esintu asetyenziswa ikakhulu kumagqabi awo, asetyenziselwa ukuthoba iswekile esegazini, ukuthintela ukubola kwamazinyo kwaye anqande ukusabela kwencasa eswiti. Nangona kunjalo, uphando lwakutsha nje lufumene ukuba imithombo yayo yesiqu nayo ityebile kwizithako ezisebenzayo, kwaye oovimba bangaphezulu kwe-10 kunamagqabi. Ngokusebenzisa indlela yokwahlula i-solvent ecwangcisiweyo, i-n-butanol kunye ne-95% ye-ethanol iingxenye ze-stem extracts zibonise i-spectra ye-UV efanayo kunye neempawu ze-chromatography ezinqamlekileyo kumagqabi, ezibonisa ukuba izithako ezisebenzayo zezi zimbini zihambelana kakhulu. Oku kufunyanisiweyo kunika inkxaso ephambili yokwandisa imithombo yamachiza kunye nokunciphisa iindleko zophuhliso.

Ukwakheka kweekhemikhali zeGymnema sylvestre isicatshulwaintsonkothile kwaye yahlukene, ingakumbi kuquka:

IiCyclols kunye ne-steroids:I-Conduritol A, njengenxalenye ephambili ye-hypoglycemic, inokukhuthaza i-glycogen synthesis; I-stigmasterol kunye ne-glucoside yayo ineempembelelo ezichasayo zokulawula;

Iikhompawundi zeSaponin:Kwi-2020, ii-saponins ezisibhozo ze-C21 steroidal saponins (gymsylvestrosides AH) zaye zodwa okokuqala, kwaye izakhiwo zazo ziqukethe i-glucuronic acid kunye neeyunithi ze-rhamnose, ezibanika umsebenzi oyingqayizivele we-biological;

Amacandelo e-Synergistic:iialkanols ezinde ezifana nelupine cinnamyl ester kunye ne-n-heptadecanol ziphucula amandla e-antioxidant ngokukhupha iiradicals zasimahla.

Kuyafaneleka ukuba uqaphele ukuba ukucoceka kwe-stem saponins kunokufikelela ngaphezu kwe-90%, kwaye ukuhlanjululwa okukhulu kunokufezekiswa ngeteknoloji ye-ethanol recrystallization, ukuphepha ukusetyenziswa kwe-solvents enobuthi njenge-chloroform.

●Yintoni naIingeneloKwe Gymnema Sylvestre Extract?

1. Ulawulo lwesifo seswekile

Uphononongo lwe-Pharmacological lubonise ukuba i-stem ethanol extract inokunciphisa amanqanaba eswekile yegazi nge-30% -40% kwiimpuku ze-alloxan zesifo seswekile, kwaye indlela yokusebenza ibonisa i-synergy yeendlela ezininzi:

Ukukhuselwa kwe-Islet: lungisa iiseli ze-β ezonakalisiweyo kunye nokwandisa i-insulin secretion;

Ukulawulwa kwe-glucose metabolism: ukukhuthaza ukuhlanganiswa kwe-glycogen yesibindi kunye nokuvimbela intestinal α-glucosidase umsebenzi (nangona izinga lokuthintela i-monomer saponin kuphela i-4.9% -9.5%, umphumo we-synergistic we-extract yonke ubalulekile);

Ukungenelela koxinzelelo lwe-oxidative: ukunciphisa amanqanaba e-lipid peroxide kunye nokwandisa umsebenzi we-superoxide dismutase.

2. I-Neuroprotection

Uphononongo olupapashwe kwiiNgxelo zeNzululwazi ngo-2025 luveze amandla okubaGymnema sylvestreisicatshulwakunyango lwe-Alzheimer's (AD):

Ukujolisa kwiiprotheyini eziphambili ze-AD: i-metabolites i-S-adenosylmethionine kunye ne-bamipine inobudlelwane obubophezelayo obuphezulu kunye ne-β-secretase (BACE1) kunye ne-monoamine oxidase B (MAO-B), ukunciphisa i-β-amyloid deposition;

Ukulawulwa kwendlela ye-Neural: ngokuvula i-cAMP / PI3K-Akt indlela yokubonisa, ukwandisa i-choline acetyltransferase (i-Chat) inkcazo, ngelixa unciphisa umsebenzi we-acetylcholinesterase, kunye nokuphucula ukuhanjiswa kwe-synaptic;

Ukuqinisekiswa kovavanyo lweseli: Kwimodeli ye-neural cell ye-Aβ42-induced, i-extract yanciphisa ukuveliswa kweentlobo ze-oxygen esebenzayo (ROS) nge-40% kunye nezinga le-apoptosis ngaphezu kwe-50%.

● Yintoni naIsiceloOf Gymnema Sylvestre Extract ?

Uphuhliso lwamachiza: I-Guangxi Guilin Jiqi Inkampani isebenzise i-saponins iyonke ye-Gymnema sylvestre (ubunyulu 98.2%) kuphuhliso lwamalungiselelo esifo seswekile1; iqela lophando laseIndiya liqhubela phambili ulingo lwangaphambili lwezicatshulwa zalo ze-neuroprotective;

Ukutya okunempilo: izicatshulwa zamagqabi zisetyenziswa njengezithinteli zobumnandi bendalo bokutya okungenaswekile; i-stem ethanol extracts iphuhliswa njengeziselo ezisebenzayo zokulawula iswekile yegazi;

Ukusetyenziswa kwezolimo: i-low-purity crude extracts isetyenziswa njengezitshabalalisi ezisekelwe kwizityalo, ezijolise kwinkqubo ye-nervous ye-arthropods kunye neepropati ezonakeleyo.

lENTSHA Unikezelo lomgangatho ophezuluGymnema Sylvestre ExtractUmgubo