Tauroursodeoxycholic acid (TUDCA), joalo ka e nkiloeng ho acid ea tlhaho ea bile, e fetohile sepheo sa indasteri ea bophelo bo botle ea lefats'e lilemong tsa morao tjena ka lebaka la ts'ireletso ea eona ea bohlokoa ea sebete le litlamorao tsa neuroprotection. Ka 2023, boholo ba mmaraka oa TUDCA oa lefats'e bo fetile lidolara tse limilione tse 350, 'me ho lebelletsoe ho fihla ho $820 milione ka 2030, ka sekhahla sa kholo ea selemo le selemo sa 12.8%. Limmaraka tsa Europe le Amerika li laoloa ke sekhahla se phahameng sa ho kenella ha lihlahisoa tsa bophelo bo botle. Sebaka sa Asia-Pacific (haholo-holo Chaena le India) se etella pele lefats'e ka sekhahla sa kholo ha palo ea mafu a sebete a sa foleng a eketseha le ntlafatso ea tšebeliso ea bophelo bo botle.
Ntle le moo, ho ea ka litokelo tsa molao tse ts'oaretsoeng ke Besty Pharmaceuticals, TUDCA e ka ntlafatsa haholo ts'ebetso ea mafu a mefuta e fapaneng ea mafu a neurodegenerative ka ho thibela neuronal apoptosis le ho fokotsa khatello ea oxidative. Ho feta moo, ts'ebeliso e tebileng ea theknoloji ea AI lipatlisisong le nts'etsopele ea lithethefatsi (joalo ka tlhahlobo ea sepheo le ntlafatso ea liteko tsa bongaka) e potlakisitse katleho ea phetoho ea bongaka ea TUDCA, 'me boholo ba mmaraka bo lebelletsoeng ho feta US $ 1 bilione lilemong tse hlano tse tlang.
●Mokhoa oa ho itokisa: ho tloha ho ntšitsoeng ka setso ho ea ho motsoako o motala
1. Mokhoa oa Setso oa ho Ema:ursodeoxycholic acid (UDCA) e arohane le bile ea bere, ebe e kopanngoa le taurine ho hlahisaTUDCA. E lekanyelitsoe ke melao ea boitšoaro ea tšireletso ea liphoofolo le bokhoni ba tlhahiso, litšenyehelo li holimo 'me butle-butle li nkeloa sebaka.
2. Mokhoa oa ho Kopanya Lik'hemik'hale:U sebelisa bile acid e le lisebelisoa tse tala, UDCA e entsoe ka oxidation, phokotso, condensation le mehato e meng, ebe e taurized. Bohloeki bo ka fihla ho feta 99%, empa mokhoa ona o rarahane mme tšilafalo e kholo.
3. Microbial Fermentation Method (Frontier Direction):Ho sebelisa Escherichia coli e entsoeng ka liphatsa tsa lefutso kapa tomoso ho kopanya ka kotlolohoTUDCA, e na le melemo ea matla a tala, a tlaase a carbon le a maholo a tlhahiso ea bongata. Ka 2023, Khamphani ea BioCore Korea Boroa e fihletse tlhahiso ea lifofane, e fokotsa litšenyehelo ka 40%.
4. Mokhoa oa ho Catalysis Enzyme:Theknoloji ea enzyme e sa sebetseng e ka susumetsa hantle motsoako oa UDCA le taurine, 'me maemo a karabelo a bobebe, a loketseng tlhahiso ea maemo a meriana.
●Melemo: Mekhoa e mengata ea ts'ebetso, e koahelang mefuta e mengata ea maloetse
Mochine oa mantlha oa TUDCA ke ho tsitsisa lera la sele, ho thibela khatello ea maikutlo ea endoplasmic reticulum le litsela tsa lipontšo tsa apoptosis, 'me e netefalitsoe ke bongaka maemong a mangata:
1. Mafu a Hepatobiliary:
⩥ Kalafo ea mantlha ea biliary cholangitis (PBC), lefu le se nang joala la mafura a sebete (NAFLD), le ho fokotsa matšoao a ALT / AST.
⩥ Fokotsa cholestasis le ho khothaletsa metabolism ea bilirubin. FDA e amohetse boemo ba eona ba lithethefatsi tsa likhutsana.
2. Tšireletso ea methapo ea kutlo:
⩥ Ntlafatsa tšenyo ea methapo ea kutlo ho lefu la Alzheimer le lefu la Parkinson. Phuputso ea 2022 ea Tlhaho e bonts'itse hore e ka fokotsa ho beoa ha β-amyloid.
⩥ E bontšitse monyetla oa ho liehisa nako ea lefu litekong tsa bongaka tsa amyotrophic lateral sclerosis (ALS).
3. Metabolism le Anti-botsofali:
⩥ Laola kutloisiso ea insulin le ho thusa taolong ea lefu la tsoekere.
⩥ Kenya ts'ebetso ea mitochondrial, eketsa nako ea bophelo ea libōpuoa tsa mohlala, 'me u be motsoako oa "lithethefatsi tsa nako e telele".
4. Lits'ebetso tsa Ophthalmic:
⩥ E na le ts'ireletso ho retinitis pigmentosa le glaucoma, 'me marotholi a amanang le mahlo a kene litekong tsa bongaka tsa Phase III.
●TUDCA libaka tsa kopo: ho tloha meriana ho ea lijong tse sebetsang
1. Lekala la Bongaka:
⩥ Lithethefatsi tsa ngaka: TUDCA e sebelisetsoang PBC, ho qhibiliha ha gallstone (joalo ka litokisetso tsa Taurursodiol tsa Europe).
⩥ Nts'etsopele ea lithethefatsi tsa likhutsana: kalafo e kopaneng bakeng sa mafu a sa tloaelehang a kang spinal muscular atrophy (SMA).
2. Lihlahisoa tsa Bophelo bo Botle:
⩥ Matlapa a tšireletso ea sebete, lihlahisoa tsa hangover: TUDCAe ka sebelisoaka silymarin le curcumin ho ntlafatsa phello.
⩥ Li-capsules tse khahlanong le botsofali: li kopantsoe le NMN le resveratrol, tse shebaneng le ho lokisa mitochondrial.
3. Phepo ea Lipapali:
⩥ Ho fokotsa ho ruruha ha mesifa ka mor'a koetliso e matla haholo, e sebelisoang e le tlatsetso ea ho hlaphoheloa ke baatlelete ba litsebi.
4. Bophelo bo Botle ba Liphoofolo:
⩥ Kalafo le tlhokomelo ea bophelo bo botle ba mafu a sebete le gallbladder ho lintja le likatse, lihlahisoa tse amanang le 'marakeng oa US li tla hola ka 35% ka 2023.
Ka palo e ntseng e eketseha ea batho ba tsofetseng le mafu a mangata a amanang le metabolic, boleng ba TUDCA litabeng tsa bongaka, tlhokomelo ea bophelo bo botle le botsofali bo tla tsoela pele ho lokolloa. Theknoloji ea maiketsetso ea baeloji e ka khothaletsa litheko le ho bula 'maraka oa bophelo bo botle ba li-yuan tse libilione tse makholo.
● Phepelo e NchaTUDCAPhofo
Nako ea poso: Apr-15-2025
