●Waa maxay Soo saarista jimicsiga Sylvestre?
Gymnema sylvestre waa geed canab ah oo ka tirsan qoyska Apocynaceae, oo si ballaaran loogu qaybiyay gobollada kulaylaha hoose sida Guangxi iyo Yunnan ee Shiinaha. Isticmaalka dawooyinka dhaqameed waxay inta badan ku urursan yihiin caleemaha, kuwaas oo loo isticmaalo hoos u dhigista sonkorta dhiigga, ka hortagga suuska iligga iyo joojinta falcelinta dhadhanka macaan. Si kastaba ha ahaatee, cilmi-baadhisyo dhowaan la sameeyay ayaa lagu ogaaday in ilaha jirkeeda ay sidoo kale hodan ku yihiin maaddooyinka firfircoon, iyo kaydka ayaa ka badan 10 jeer caleemaha. Iyada oo loo marayo habka kala-soocidda dareeraha nidaamsan, n-butanol iyo 95% ethanol qaybo ka mid ah soosaarayaasha asliga ah waxay muujiyeen astaamo UV oo la mid ah iyo astaamo chromatography oo khafiif ah caleemaha, taas oo muujinaysa in maaddooyinka firfircoon ee labada ay yihiin kuwo aad u joogto ah. Daah-furkaani wuxuu bixiyaa taageerada muhiimka ah ee ballaarinta ilaha daroogada iyo dhimista kharashka horumarinta.
Halabuurka kiimikada eeSylvestre-ga jimicsiga soosaaridwaa kakan oo kala duwan, oo ay ku jiraan:
Cyclols iyo steroids:Conduritol A, oo ah qaybta asaasiga ah ee hypoglycemic, waxay kor u qaadi kartaa isku-dhafka glycogen; stigmasterol iyo glukoside-keeda waxay leeyihiin saameyn lid ku ah xakamaynta bararka;
Iskudhisyada Saponin:Sannadka 2020, siddeed saponins oo C21 cusub ah (gymsylvestrosides AH) ayaa la go'doomiyey markii ugu horreysay, qaab-dhismeedkooduna waxa ka kooban unugyo glucuronic acid iyo rhamnose, taasoo siinaya dhaqdhaqaaq noole oo gaar ah;
Qaybaha is dhexgalka:Alkanols-ka silsiladda dheer sida lupine cinnamyl ester iyo n-heptadecanol waxay kor u qaadaan awoodda antioxidant iyagoo iska tuuraya xagjirrada xorta ah.
Waxaa xusid mudan in nadiifinta saponins-ka asliga ah ay gaari karto in ka badan 90%, sifeyn ballaaranna waxaa lagu gaari karaa tignoolajiyada dib-u-kicinta ethanol, iyadoo laga fogaanayo isticmaalka dareerayaasha sunta ah sida chloroform.
●Maxay YihiinFaa'iidooyinkaee Soo saarista jimicsiga Sylvestre?
1. Maareynta Macaanka
Daraasadaha dawooyinka ayaa muujiyay in laga soosaaray ethanol stem ay hoos u dhigi karto heerarka sonkorta dhiigga 30% -40% ee jiirarka sonkorowga alloxan, iyo habka ficilku wuxuu muujinayaa isku-dhafka waddooyinka badan:
Ilaalinta jasiiradaha: hagaajinta unugyada beta ee dhaawacan waxayna kordhisaa dheecaanka insulin;
Nidaaminta dheef-shiid kiimikaadka gulukooska: waxay kor u qaaddaa isku-dhafka glycogen ee beerka waxayna joojisaa dhaqdhaqaaqa xiidmaha α-glucosidase (in kasta oo heerka xakamaynta monomer saponin uu yahay 4.9% -9.5% kaliya, saameynta isku-dhafka ah ee soosaarka oo dhan waa mid muhiim ah);
Faragelinta cadaadiska Oxidative: hoos u dhig heerarka lipid peroxide waxayna kordhisaa firfircoonida dismutase superoxide.
2. Ilaalinta neerfaha
Daraasad lagu daabacay Warbixinnada Sayniska ee 2025 ayaa shaaca ka qaaday suurtagalnimadaSylvestre-ga jimicsigasoosaariddaawaynta cudurka Alzheimers (AD):
Bartilmaameedka borotiinka AD ee muhiimka ah: metabolites S-adenosylmethionine iyo bamipine waxay leeyihiin xiriir sare oo ku xiran β-secretase (BACE1) iyo monoamine oxidase B (MAO-B), hoos u dhigista β-amyloid;
Xeerarka dariiqa neerfaha: iyada oo la dhaqaajinayo dariiqa calaamadaynta cAMP/PI3K-Akt, kordhinta muujinta choline acetyltransferase (Chat), iyada oo la dhimayo dhaqdhaqaaqa acetylcholinesterase, iyo hagaajinta gudbinta synaptik;
Xaqiijinta tijaabada unugyada: Qaabka unugyada neerfaha ee Aβ42, soosaarku wuxuu hoos u dhigay jiilka noocyada ogsijiinta falcelinta (ROS) 40% iyo heerka apoptosis in ka badan 50%.
● Maxay YihiinCodsigaOf Soo saarista jimicsiga Sylvestre ?
Horumarinta dawooyinka: Shirkadda Guangxi Guilin Jiqi waxay isticmaashay wadarta saponins ee Gymnema sylvestre (nadiifinta 98.2%) horumarinta diyaarinta sonkorowga1; Kooxda cilmi-baarista Hindiya waxay horumarinayaan tijaabooyinka hore ee ka-soo-baxyada neerfaha;
Cunto caafimaad leh: laga soosaaray caleenta waxaa loo isticmaalaa ka hortagga macaanka dabiiciga ah cuntooyinka aan sonkorta lahayn; Astaamaha ethanol ee asliga ah ayaa loo soo saaray sidii cabitaano shaqeynaya oo loogu talagalay nidaaminta sonkorta dhiigga;
Codsiyada beeraha: Soosaarrada cayriin ee nadiifka ah ee hooseeya ayaa loo isticmaalaa sida cayayaanka dhirta ku salaysan, iyada oo la beegsanayo habka dareemayaasha ee arthropods iyo isagoo leh sifooyin hoos u dhacaya.
lAgab Cusub oo Tayo Sare lehSoo saarista jimicsiga SylvestreBudada
Waqtiga boostada: Jul-21-2025
