Tauroursodeoxycholic Acid (TUDCA), seyakatorwa kubva kune yakasikwa bile acid, yave yakatarisana neindasitiri yehutano yepasi rose mumakore achangopfuura nekuda kwekuchengetedza kwayo kwakakosha kwechiropa uye neuroprotection mhedzisiro. Muna 2023, saizi yemusika wepasi rose yeTUDCA yakapfuura US$350 miriyoni, uye inotarisirwa kusvika US$820 miriyoni muna 2030, nekukura kwepagore kwekukura kwe12.8%. Misika yeEurope neAmerica inotongwa nehuwandu hwekupinda kwezvigadzirwa zvehutano. Nharaunda yeAsia-Pacific (kunyanya China neIndia) inotungamira pasi rose mukukura kwekukura sezvo chiitiko chechirwere chisingaperi chechiropa chinowedzera uye kushandiswa kwehutano kunowedzera.
Kunze kwezvo, maererano nemvumo inobatwa naBesty Pharmaceuticals, TUDCA inogona kuvandudza zvakanyanya hurongwa hwehutachiona hwezvirwere zvakasiyana-siyana neurodegenerative nekudzivisa neuronal apoptosis uye kuderedza oxidative kusagadzikana. Pamusoro pezvo, kushandiswa kwakadzama kweAI tekinoroji mukutsvagisa zvinodhaka nekusimudzira (sekutariswa kwechinangwa uye kukwidziridzwa kwekuyedza kwekiriniki) kwakawedzera hunyanzvi hwekushandura kiriniki yeTUDCA, uye saizi yemusika yakakodzera inotarisirwa kudarika US $ 1 bhiriyoni mumakore mashanu anotevera.
●Kugadzirira nzira: kubva pachinyakare kudhirowa kune yakasvibira synthesis
1. Traditional Extract Method:ursodeoxycholic acid (UDCA) inoparadzaniswa nebere bile, yozosanganiswa netaurine kugadzira.TUDCA. Yakaganhurirwa nemaitiro ekuchengetedza mhuka uye kugona kwekugadzira, mutengo wakakwira uye unotsiviwa zvishoma nezvishoma.
2. Chemical Synthesis Method:Ichishandisa bile acid seyakagadzirwa, UDCA inogadzirwa kuburikidza neoxidation, kudzikisira, condensation uye mamwe matanho, uyezve taurized. Kuchena kunogona kusvika kupfuura 99%, asi maitiro acho akaoma uye kusvibiswa kwakakura.
3. Microbial Fermentation Method (Frontier Direction):Kushandisa genetically engineered Escherichia coli kana mbiriso kugadzira zvakanangaTUDCA, ine zvakanakira zvegirini, yakaderera-kabhoni uye yakakura misa yekugadzira. Muna 2023, BioCore Kambani muSouth Korea yakawana kugadzirwa kwendege, ichidzikisa mutengo ne40%.
4. Enzyme Catalysis Nzira:Immobilized enzyme tekinoroji inogona kunyatso kukonzeresa musanganiswa weUDCA uye taurine, uye maitiro ekuita akapfava, ayo akakodzera kugadzirwa kwemishonga-giredhi.
●Benefits: Multi-target nzira yekuita, inovhara nzvimbo dzakasiyana siyana dzechirwere
Iyo yakakosha mashandiro eTUDCA ndeyekudzikamisa sero membrane, inhibit endoplasmic reticulum kushushikana uye apoptosis siginecha nzira, uye yakasimbiswa nekiriniki mune dzakawanda zviitiko:
1. Hepatobiliary Zvirwere:
⩥ Kurapa kweprimary biliary cholangitis (PBC), non-alcoholic fatty chiropa chirwere (NAFLD), uye kuderedza zviratidzo zveALT / AST.
⩥ Bvisa cholestasis uye kusimudzira bilirubin metabolism. Iyo FDA yakatendera chimiro chayo chemushonga wenherera.
2. Neuroprotection:
⩥ Kuvandudza neuronal kukuvara kwechirwere cheAlzheimer uye chirwere cheParkinson. Chidzidzo che2022 Chisikwa chakaratidza kuti chinogona kuderedza β-amyloid deposition.
⩥ Yakaratidza kukwanisa kunonoka nzira yechirwere mumakiriniki ekuedzwa kweamyotrophic lateral sclerosis (ALS).
3. Metabolism uye Anti-Kuchembera:
⩥ Regulate insulin senitivity uye kubatsira mukutarisira chirwere cheshuga.
⩥ Shandisa mitochondrial basa, wedzera hupenyu hwemhando yezvipenyu, uye uve mumiriri we "mishonga yehupenyu hurefu".
4. Ophthalmic Applications:
⩥ Iyo ine inodzivirira paretinitis pigmentosa uye glaucoma, uye madonhwe emeso ane hukama apinda muChikamu chechitatu chekiriniki miedzo.
●TUDCA nzvimbo dzekushandisa: kubva kumushonga kuenda kune inoshanda chikafu
1. Medical Field:
⩥ Mishonga yemishonga: TUDCA inoshandiswa kuPBC, gallstone dissolution (yakadai seEuropean Taurursodiol preparations).
⩥ Nherera kugadzirwa kwezvinodhaka: musanganiswa kurapa zvirwere zvisingawanzoitiki senge spinal muscular atrophy (SMA).
2. Zvigadzirwa zvehutano:
⩥ Mahwendefa ekudzivirira chiropa, hangover zvigadzirwa: TUDCAinogona kushandiswane silymarin uye curcumin kuwedzera mhedzisiro.
⩥ Anti-aging capsules: yakasanganiswa neNMN uye resveratrol, inotarisa kugadzirisa mitochondrial.
3. Zvokudya Zvokudya:
⩥ Kuderedza kuzvimba kwemhasuru mushure mekudzidziswa kwakasimba, kunoshandiswa sekuwedzera kwekuwedzera nevatambi vehunyanzvi.
4. Hutano hwePeti:
⩥ Kurapa uye hutano hwehutano hwechiropa uye gallbladder zvirwere mumbwa nekatsi, zvigadzirwa zvine hukama mumusika weUS zvichakura ne35% muna 2023.
Nekuwedzera kwehuwandu hwekuchembera uye kuwanda kwezvirwere zvemetabolism, kukosha kweTUDCA muminda yemishonga, hutano hwehutano, uye kurwisa kuchembera kuchaburitswa zvakare. Synthetic biology tekinoroji inogona kusimudzira mitengo inokwanisika uye kuvhura musika wehutano unokosha mazana emabhiriyoni emayuan.
●NEWGREEN SupplyTUDCAUpfu
Nguva yekutumira: Kubvumbi-15-2025
