Acide ya Tauroursodeoxycholic (TUDCA), nkibikomoka kuri acide naturel, yabaye intandaro yinganda zubuzima ku isi mumyaka yashize kubera kurinda umwijima ningaruka za neuroprotection. Mu 2023, isoko rya TUDCA ku isi ryarenze miliyoni 350 z'amadolari y'Amerika, bikaba biteganijwe ko rizagera kuri miliyoni 820 z'amadolari ya Amerika mu 2030, hamwe n'ubwiyongere bw'umwaka buri mwaka bwa 12.8%. Amasoko yu Burayi na Amerika yiganjemo umuvuduko mwinshi w’ibicuruzwa byubuzima. Agace ka Aziya-Pasifika (cyane cyane Ubushinwa n'Ubuhinde) kiyobora isi mu iterambere mu gihe ubwiyongere bw'indwara z'umwijima zidakira bwiyongera ndetse no kuzamura ubuzima.
Uretse ibyo, ukurikije patenti zifitwe na Besty Pharmaceuticals, TUDCA irashobora kunoza cyane inzira y’indwara z’indwara zitandukanye zifata ubwonko mu guhagarika apoptose ya neuronal no kugabanya imihangayiko ya okiside. Byongeye kandi, gushyira mu bikorwa byimbitse ikoranabuhanga rya AI mu bushakashatsi bw’ibiyobyabwenge n’iterambere (nko gusuzuma intego no kugerageza kugerageza kwa kliniki) byihutishije imikorere yo guhindura amavuriro ya TUDCA, kandi biteganijwe ko ingano y’isoko ijyanye na miliyari imwe y’amadolari mu myaka itanu iri imbere.
●Uburyo bwo kwitegura: kuva gakondo gakondo kugeza synthesis
1. Uburyo bwo kuvoma gakondo:acide ursodeoxycholic (UDCA) itandukanijwe nidubu, hanyuma igahuzwa na taurine kugirango itange umusaruroTUDCA. Bitewe nubwitonzi bwo kurinda inyamaswa nubushobozi bwo kubyaza umusaruro, igiciro ni kinini kandi gisimburwa buhoro buhoro.
2. Uburyo bwa Sintezike yimiti:Ukoresheje aside aside nkibikoresho fatizo, UDCA ikomatanyirizwa hamwe binyuze muri okiside, kugabanya, kondegeranya nizindi ntambwe, hanyuma ikabikwa neza. Isuku irashobora kugera kuri 99%, ariko inzira iragoye kandi umwanda ni munini.
3. Uburyo bwa Microbial Fermentation Uburyo (Icyerekezo cyimbere):Gukoresha genetiki ya Escherichia coli cyangwa umusemburo kugirango uhuze nezaTUDCA, ifite ibyiza byicyatsi kibisi, karuboni nkeya nubushobozi bunini bwo gukora. Mu 2023, Isosiyete ya BioCore muri Koreya yepfo yageze ku musaruro w’icyitegererezo, igabanya ibiciro 40%.
4. Uburyo bwa Catalizike ya Enzyme:Ikoreshwa rya enzyme yimisemburo irashobora guhagarika neza guhuza UDCA na taurine, kandi imiterere yimyitwarire iroroshye, ikwiranye nogukora imiti yo murwego rwa farumasi.
●Inyungu: Uburyo butandukanye bwibikorwa, bikubiyemo ahantu henshi h’indwara
Uburyo bwibanze bwa TUDCA nuguhindura ingirabuzimafatizo, guhagarika imitekerereze ya endoplasmic reticulum hamwe na apoptose yerekana inzira, kandi byagenzuwe mubuvuzi kenshi:
1. Indwara za Hepatobiliary:
Kuvura indwara ya biliary cholangitis (PBC), indwara y'umwijima idafite inzoga (NAFLD), no kugabanya ibipimo bya ALT / AST.
Kuraho cholestasis no guteza imbere metabolisme ya bilirubin. FDA yemeye imiterere yibiyobyabwenge byimfubyi.
2. Neuroprotection:
Kunoza kwangirika kwa neuronal mu ndwara ya Alzheimer n'indwara ya Parkinson. Ubushakashatsi bwibidukikije 2022 bwerekanye ko bushobora kugabanya β-amyloide.
Yerekanye ubushobozi bwo gutinza inzira yindwara mugupima kwa amyotrophique lateral sclerose (ALS).
3. Metabolism no Kurwanya Gusaza:
⩥ Kugenzura ibyiyumvo bya insuline no gufasha mugucunga diyabete.
Kora imikorere ya mito-iyambere, kwagura igihe cyibinyabuzima byintangarugero, kandi ube umukandida w "imiti iramba".
4. Porogaramu y'amaso:
Has Ifite ingaruka zo gukingira retinitis pigmentosa na glaucoma, kandi ibitonyanga by'amaso bifitanye isano byinjiye mu kizamini cya Phase III.
●TUDCA ahakoreshwa: kuva mubuvuzi kugeza ibiryo bikora
1. Ubuvuzi:
⩥ Imiti yandikiwe: TUDCA ikoreshwa muri PBC, gusohora amabuye (nk'imyiteguro ya Taurursodiol yu Burayi).
⩥ Guteza imbere imiti yimfubyi: kuvura indwara zidasanzwe nka spropine muscular atrophy (SMA).
2. Ibicuruzwa byubuzima:
⩥ Ibinini birinda umwijima, ibicuruzwa byamanikwa: TUDCAirashobora gukoreshwahamwe na silymarin na curcumin kugirango byongere ingaruka.
⩥ Kurwanya gusaza capsules: hiyongereyeho NMN na resveratrol, byibanda ku gusana mitochondial.
3. Imirire ya siporo:
⩥ Kugabanya uburibwe bwimitsi nyuma yimyitozo yimbaraga nyinshi, ikoreshwa nkinyongera yo gukira nabakinnyi babigize umwuga.
4. Ubuzima bwamatungo:
⩥ Kuvura no kwita ku ndwara n’umwijima n’imbwa n’imbwa, ibicuruzwa bifitanye isano n’isoko ry’Amerika biziyongera 35% muri 2023.
Ubwiyongere bw'abaturage bageze mu za bukuru hamwe n'indwara nyinshi ziterwa na metabolike, agaciro ka TUDCA mu bijyanye n'ubuvuzi, ubuvuzi, ndetse no kurwanya gusaza bizashyirwa ahagaragara. Ikoranabuhanga ryibinyabuzima ryogukora rishobora kuzamura ibiciro bihendutse no gufungura isoko ryubuzima rifite agaciro ka miliyari amagana.
Isoko RishyaTUDCAIfu
Igihe cyo kohereza: Apr-15-2025
