Gymnema Sylvestre Ibikururwa: Iterambere ryambukiranya imipaka kuva mubyatsi gakondo bya hypoglycemic kugeza inyenyeri nshya muri neuroprotection

●Niki Gymnema Sylvestre Gukuramo?

Gymnema sylvestre ni umuzabibu wumuryango wa Apocynaceae, ukwirakwizwa cyane mu turere dushyuha nka Guangxi na Yunnan mu Bushinwa. Imiti gakondo ikoreshwa cyane cyane yibibabi byayo, bikoreshwa mukugabanya isukari yamaraso, kurinda amenyo no kubuza uburyohe uburyohe. Nyamara, ubushakashatsi buherutse gukorwa bwerekanye ko umutungo wacyo wacyo ukungahaye ku bintu bifatika, kandi ibigega bikubye inshuro zirenga 10 ibyo amababi. Binyuze muburyo butandukanye bwo gutandukanya ibishishwa, n-butanol hamwe na 95% bya Ethanol yibikomoka kumurongo wibiti byerekanaga UV yerekanwe hamwe na chromatografiya yoroheje yibibabi biranga amababi, byerekana ko ibintu bikora byombi bihuye cyane. Ubu buvumbuzi butanga inkunga yingenzi yo kwagura inkomoko yibiyobyabwenge no kugabanya ibiciro byiterambere.

Ibigize imiti yaGymnema sylvestre gukuramoni bigoye kandi bitandukanye, cyane cyane harimo:

Amagare na steroid:Conduritol A, nkibigize hypoglycemic yibigize, irashobora guteza imbere synthesis ya glycogene; stigmasterol na glucoside yayo bigira ingaruka zo kurwanya inflammatory;

Ibikoresho bya Saponin:Muri 2020, umunani mushya wa C21 steroidal saponine (gymsylvestroside AH) wahawe akato ku nshuro ya mbere, kandi imiterere yabyo irimo aside glucuronic na rhamnose, ibaha ibikorwa bidasanzwe by’ibinyabuzima;

Ibice bikomatanya:alkanol ndende-ndende nka lupine cinnamyl ester na n-heptadecanol byongera ubushobozi bwa antioxydeant mugukata radicals yubusa.

Birakwiye ko tumenya ko ubuziranenge bwa saponine stem bushobora kugera kuri 90%, kandi isuku nini irashobora kugerwaho hifashishijwe ikoranabuhanga rya Ethanol ryongera kwifashisha, wirinda gukoresha imiti yuburozi nka chloroform.

●NikiInyunguBya Gymnema Sylvestre Gukuramo?

1. Gucunga diyabete

Ubushakashatsi bwa farumasi bwerekanye ko ibishishwa bya Ethanol bishobora kugabanya urugero rwisukari mu maraso 30% -40% mu mbeba za diyabete ya alloxan, kandi uburyo bwibikorwa bwerekana guhuza inzira nyinshi:

Kurinda ikirwa: gusana ibyangiritse β selile no kongera insuline;

Glucose metabolism igenga: guteza imbere synthèse yumwijima glycogene no guhagarika ibikorwa byo munda α-glucosidase yo munda (nubwo igipimo cyo kubuza monomer saponin ari 4.9% -9.5% gusa, ingaruka zo guhuza ibice byose ni ngombwa);

Oxidative stress intervention: kugabanya urugero rwa lipide peroxide no kongera ibikorwa bya superoxide.

2. Neuroprotection

Ubushakashatsi bwasohotse muri Scientific Reports mu 2025 bwerekanye ubushobozi bwaGymnema sylvestregukuramomu kuvura indwara ya Alzheimer (AD):

Kwibanda kuri poroteyine z'ingenzi za AD: metabolite S-adenosylmethionine na bamipine bifitanye isano rya bugufi na β-secretase (BACE1) na okiside monoamine B (MAO-B), kugabanya β-amyloide;

Amabwiriza yinzira nyabagendwa: mugukoresha cAMP / PI3K-Akt yerekana inzira yerekana inzira, kongera imvugo ya choline acetyltransferase (ChAT), mugihe ugabanya ibikorwa bya acetylcholinesterase, no kunoza kwanduza synaptic;

Kugenzura ubushakashatsi bwakagari: Muri moderi ya Aβ42 iterwa na selile selile selile, ibiyikuramo byagabanije kubyara amoko ya ogisijeni ikora (ROS) 40% naho igipimo cya apoptose kirenga 50%.

● NikiGusabaOf Gymnema Sylvestre Gukuramo ?

Iterambere ryimiti: Isosiyete ya Guangxi Guilin Jiqi yakoresheje saponine yuzuye ya Gymnema sylvestre (ubuziranenge 98.2%) mugutezimbere imyiteguro ya diyabete1; itsinda ry’ubushakashatsi mu Buhinde ririmo guteza imbere ibigeragezo by’ibikomoka kuri neuroprotective;

Ibiryo byubuzima bwiza: ibibabi bivamo amababi bikoreshwa nkibibuza uburyohe busanzwe kubiribwa bidafite isukari; ibiti bivamo ibiti bya Ethanol byakozwe nkibinyobwa bikora bigenga isukari yamaraso;

Porogaramu zikoreshwa mu buhinzi: ibivuye mu bucukuzi buke bikoreshwa nk’udukoko twangiza udukoko twangiza ibihingwa, byibasira sisitemu yimitsi ya arthropods kandi ifite ibintu byangirika.

lNEWGREEN Tanga ubuziranengeGymnema Sylvestre GukuramoIfu