Tauroursodeoxycholic Acid (TUDCA), monga chotengera chachilengedwe cha bile acid, chakhala chofunikira kwambiri pamakampani azaumoyo padziko lonse lapansi m'zaka zaposachedwa chifukwa chachitetezo chake chachikulu cha chiwindi komanso zotsatira za neuroprotection. Mu 2023, kukula kwa msika wapadziko lonse wa TUDCA kudapitilira $350 miliyoni, ndipo akuyembekezeka kufika $820 miliyoni mu 2030, ndikukula kwapachaka kwa 12.8%. Misika yaku Europe ndi America imayang'aniridwa ndi kuchuluka kwamphamvu kwazinthu zamankhwala. Dera la Asia-Pacific (makamaka China ndi India) likutsogolera dziko lonse pakukula kwa chiwerengero cha matenda aakulu a chiwindi akuwonjezeka komanso kuwonjezereka kwa thanzi labwino.
Kupatula apo, malinga ndi ma patent omwe Besty Pharmaceuticals ali nawo, TUDCA imatha kusintha kwambiri njira zamatenda osiyanasiyana a neurodegenerative poletsa neuronal apoptosis ndikuchepetsa kupsinjika kwa okosijeni. Kuphatikiza apo, kugwiritsa ntchito mozama kwaukadaulo wa AI pakufufuza ndi chitukuko chamankhwala (monga kuwunika chandamale ndi kukhathamiritsa kwa mayeso azachipatala) kwathandizira kusintha kwachipatala kwa TUDCA, ndipo kukula kwa msika woyenerera kukuyembekezeka kupitilira US $ 1 biliyoni pazaka zisanu zikubwerazi.
●Kukonzekera njira: kuchokera miyambo m'zigawo kuti zobiriwira kaphatikizidwe
1. Njira Yachikhalidwe Yochotsera:ursodeoxycholic acid (UDCA) imasiyanitsidwa ndi bile, kenako ndikuphatikizidwa ndi taurine kuti ipange.TUDCA. Zochepa ndi malamulo oteteza zinyama ndi mphamvu zopangira, mtengo wake ndi wokwera ndipo umasinthidwa pang'onopang'ono.
2. Njira Yophatikizira Chemical:Pogwiritsa ntchito bile acid ngati zopangira, UDCA imapangidwa kudzera mu oxidation, kuchepetsa, condensation ndi masitepe ena, kenako nditaurized. Chiyerocho chikhoza kufika kupitirira 99%, koma ndondomekoyi ndi yovuta komanso kuipitsa kwakukulu.
3. Njira ya Microbial Fermentation (Frontier Direction):Kugwiritsa ntchito chibadwa Escherichia coli kapena yisiti kupanga mwachindunjiTUDCA, ili ndi ubwino wokhala ndi zobiriwira, zotsika kwambiri za carbon ndi mphamvu zazikulu zopanga misa. Mu 2023, Kampani ya BioCore ku South Korea yakwanitsa kupanga oyendetsa, kuchepetsa ndalama ndi 40%.
4. Enzyme Catalysis Njira:Ukadaulo wa enzyme wosasunthika ukhoza kuthandizira kuphatikiza kwa UDCA ndi taurine, ndipo momwe zimachitikira ndizochepa, zomwe ndizoyenera kupanga mankhwala.
●Ubwino: Njira zambiri zogwirira ntchito, zomwe zimakhudza madera osiyanasiyana a matenda
Njira yayikulu ya TUDCA ndikukhazikitsa nembanemba ya cell, kuletsa kupsinjika kwa endoplasmic reticulum ndi njira zowonetsera ma apoptosis, ndipo zatsimikiziridwa ndichipatala nthawi zambiri:
1. Matenda a Hepatobiliary:
⩥ Chithandizo cha primary biliary cholangitis (PBC), non-alcoholic fatty chiwindi matenda (NAFLD), ndi kuchepetsa zizindikiro za ALT/AST.
⩥ Kuchepetsa cholestasis ndikulimbikitsa bilirubin metabolism. A FDA avomereza udindo wake wa mankhwala amasiye.
2. Neuroprotection:
⩥ Kupititsa patsogolo kuwonongeka kwa neuronal mu matenda a Alzheimer's ndi Parkinson's. Kafukufuku wa 2022 Natural adawonetsa kuti imatha kuchepetsa kuyika kwa β-amyloid.
⩥ Anawonetsa kuthekera kochedwetsa matenda m'mayesero azachipatala a amyotrophic lateral sclerosis (ALS).
3. Metabolism Ndi Anti-Kukalamba:
⩥ Kuwongolera kukhudzidwa kwa insulin ndikuthandizira pakuwongolera matenda a shuga.
⩥ Yambitsani ntchito ya mitochondrial, onjezerani nthawi ya moyo wa zamoyo zachitsanzo, ndikukhala gawo la "mankhwala a moyo wautali".
4. Kugwiritsa Ntchito Ophthalmic:
⩥ Imakhala ndi zoteteza pa retinitis pigmentosa ndi glaucoma, ndipo madontho ogwirizana nawo alowa m'mayesero achipatala a Phase III.
●TUDCA madera ogwiritsira ntchito: kuchokera ku mankhwala kupita ku chakudya chogwira ntchito
1. Malo azachipatala:
⩥ Mankhwala osokoneza bongo: TUDCA yogwiritsidwa ntchito pa PBC, kusungunuka kwa ndulu (monga kukonzekera kwa European Taurursodiol).
⩥ Kukula kwamankhwala kwa ana amasiye: chithandizo chophatikiza cha matenda osowa monga spinal muscular atrophy (SMA).
2. Zaumoyo:
⩥ Mapiritsi oteteza chiwindi, mankhwala osokoneza bongo: TUDCAakhoza kugwiritsidwa ntchitondi silymarin ndi curcumin kuti muwonjezere mphamvu.
⩥ Makapisozi oletsa kukalamba: ophatikizidwa ndi NMN ndi resveratrol, amayang'ana kwambiri kukonza mitochondrial.
3. Chakudya Chamasewera:
⩥ Kuchepetsa kutupa kwa minofu pambuyo pa maphunziro apamwamba kwambiri, omwe amagwiritsidwa ntchito ngati chowonjezera chothandizira ndi akatswiri othamanga.
4. Thanzi la Ziweto:
⩥ Chithandizo ndi chisamaliro cha matenda a chiwindi ndi ndulu mu agalu ndi amphaka, zinthu zokhudzana ndi msika waku US zidzakula ndi 35% mu 2023.
Ndi kuchuluka kwa ukalamba komanso kuchuluka kwa matenda a metabolic, kufunikira kwa TUDCA pazamankhwala, chisamaliro chaumoyo, komanso kuletsa kukalamba kudzatulutsidwanso. Ukadaulo wopangidwa ndi biology ukhoza kulimbikitsa mitengo yotsika mtengo ndikutsegula msika wazaumoyo wandalama mabiliyoni a yuan.
● Zatsopano ZatsopanoTUDCAUfa
Nthawi yotumiza: Apr-15-2025
