Gymnema Sylvestre Extract: Kupambana kosiyanasiyana kuchokera ku zitsamba zachikhalidwe za hypoglycemic kupita ku nyenyezi yatsopano mu neuroprotection.

●Kodi Ndi Chiyani Gymnema Sylvestre Extract?

Gymnema sylvestre ndi mpesa wa banja la Apocynaceae, wofalitsidwa kwambiri kumadera otentha monga Guangxi ndi Yunnan ku China. Mankhwala achikhalidwe amagwiritsidwa ntchito makamaka pamasamba ake, omwe amagwiritsidwa ntchito kuchepetsa shuga m'magazi, kupewa kuwola kwa mano komanso kuletsa kukoma kokoma. Komabe, kafukufuku waposachedwapa apeza kuti tsinde lake lilinso ndi zinthu zambiri zogwira ntchito, ndipo nkhokwe zake zimaposa kakhumi kuposa masambawo. Kupyolera mu njira zosungunulira zosungunulira kulekana, mbali ya n-butanol ndi 95% ethanol ya tsinde akupanga anasonyeza ofanana UV sipekitiramu ndi woonda wosanjikiza chromatography makhalidwe kwa masamba, kusonyeza kuti yogwira zosakaniza awiriwa kwambiri zogwirizana. Kupeza kumeneku kumapereka chithandizo chofunikira pakukulitsa magwero a mankhwala ndi kuchepetsa mtengo wa chitukuko.

The mankhwala zikuchokeraGymnema sylvestre kuchotsandizovuta komanso zosiyanasiyana, makamaka kuphatikiza:

Cyclols ndi Steroids:Conduritol A, monga gawo lalikulu la hypoglycemic, imatha kulimbikitsa kaphatikizidwe ka glycogen; stigmasterol ndi glucoside yake imakhala ndi zotsutsana ndi zotupa;

Zosakaniza za Saponin:Mu 2020, asanu ndi atatu atsopano a C21 steroidal saponins (gymsylvestrosides AH) adadzipatula kwa nthawi yoyamba, ndipo mapangidwe awo ali ndi glucuronic acid ndi mayunitsi a rhamnose, kuwapatsa ntchito yapadera yachilengedwe;

Zida za Synergistic:ma alkanols atalitali monga lupine cinnamyl ester ndi n-heptadecanol amathandizira mphamvu ya antioxidant pochotsa ma radicals aulere.

Dziwani kuti chiyero cha tsinde saponins akhoza kufika kuposa 90%, ndi kuyeretsedwa kwakukulu kungapezeke kudzera muukadaulo wa ethanol recrystallization, kupewa kugwiritsa ntchito zosungunulira zakupha monga chloroform.

●Ndi ChiyaniUbwinoZa Gymnema Sylvestre Extract?

1. Matenda a shuga

Kafukufuku wamankhwala awonetsa kuti tsinde la ethanol lingachepetse shuga wamagazi ndi 30% -40% mu mbewa za alloxan odwala matenda ashuga, ndipo limagwirira ntchito likuwonetsa synergy yanjira zambiri:

Chitetezo cha pachisumbu: kukonza ma cell a β owonongeka ndikuwonjezera kutulutsa kwa insulin;

Kuwongolera kagayidwe ka shuga: kulimbikitsa kaphatikizidwe ka glycogen m'chiwindi ndikuletsa ntchito ya m'mimba ya α-glucosidase (ngakhale kuletsa kwa monomer saponin ndi 4.9% -9.5% yokha, mphamvu ya synergistic ya chotsitsa chonse ndi yofunika);

Kulowererapo kwa oxidative: kuchepetsa kuchuluka kwa lipid peroxide ndikuwonjezera ntchito ya superoxide dismutase.

2. Neuroprotection

Kafukufuku wofalitsidwa mu Scientific Reports mu 2025 adawulula kuthekera kwaGymnema sylvestrekuchotsapochiza matenda a Alzheimer's (AD):

Kulimbana ndi mapuloteni ofunika kwambiri a AD: metabolites S-adenosylmethionine ndi bamipine ali ndi kugwirizana kwakukulu ndi β-secretase (BACE1) ndi monoamine oxidase B (MAO-B), kuchepetsa kuyika kwa β-amyloid;

Malamulo a Neural pathway: poyambitsa njira yowonetsera cAMP/PI3K-Akt, kuonjezera choline acetyltransferase (Chat), pamene kuchepetsa ntchito ya acetylcholinesterase, ndi kupititsa patsogolo kufalikira kwa synaptic;

Kutsimikizira kuyesa kwa ma cell: Muchitsanzo cha Aβ42-induced neural cell, chotsitsacho chinachepetsa kutulutsa kwa mitundu ya okosijeni (ROS) ndi 40% komanso kuchuluka kwa apoptosis kupitilira 50%.

● Ndi ChiyaniKugwiritsa ntchitoOf Gymnema Sylvestre Extract ?

Kukula kwamankhwala: Kampani ya Guangxi Guilin Jiqi yagwiritsa ntchito saponins yonse ya Gymnema sylvestre (kuyera 98.2%) popanga chithandizo cha matenda a shuga1; gulu lofufuza la ku India likupititsa patsogolo mayeso a preclinical a zowonjezera zake za neuroprotective;

Chakudya chathanzi: masamba a masamba amagwiritsidwa ntchito ngati zoletsa zotsekemera zachilengedwe pazakudya zopanda shuga; tsinde Mowa akupanga amapangidwa ngati zakumwa zinchito zowongolera shuga m'magazi;

Ntchito zaulimi: Zotulutsa zopanda ukhondo zotsika zimagwiritsidwa ntchito ngati mankhwala ophera tizilombo, omwe amayang'ana dongosolo lamanjenje la arthropods komanso kukhala ndi zinthu zosawonongeka.

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