● What Is Synephrine Hydrochloride ?
Synephrine HCl is the hydrochloride form of synephrine, with the chemical formula C₉H₁₃NO₂·HCl (molecular weight 203.67). Its natural precursor synephrine is mainly derived from the dried young fruits (citrus aurantium) of the Rutaceae plant. Citrus aurantium is widely distributed in the Yangtze River Basin provinces of China, such as Sichuan, Jiangxi, and Zhejiang. The synephrine content in its young fruits can reach up to 30% of the dry weight. Traditional extraction relies on alcohol extraction (75% ethanol reflux extraction 3 times, yield ≥ 85%), but in recent years, technological innovation has focused on green and high efficiency:
Enzymatic hydrolysis-membrane separation: compound pectinase hydrolyzes pectin at 40°C and pH 4.5, combined with 0.22μm inorganic ceramic membrane filtration, the impurity removal rate reaches 91%, and the purity is increased to more than 95%;
Fungal substitution technology: The Chinese Academy of Agricultural Sciences has developed a Ganoderma lucidum fermentation method to produce synephrine-like substances, reducing costs by 30% and alleviating the pressure of illegal mining of wild resources.
● What Are The Benefits Of Synephrine Hydrochloride ?
Synephrine hydrochloride, as a dual agonist of adrenaline α/β receptors, reshapes clinical value through multi-target effects:
1. Cardiovascular Emergency
Exciting α receptors to constrict blood vessels and increase blood pressure, which is used for anesthesia, hypotension, shock rescue, and the onset speed is 40% faster than traditional drugs;
Activating β receptors to enhance myocardial contractility and improve the pumping function of patients with heart failure.
2. Respiratory System Intervention
Synephrine hydrochloride can strongly dilate bronchial smooth muscle, completely antagonize histamine-induced spasm, and increase the FEV1 index of lung function in patients with bronchial asthma by 25%.
3. Metabolic Regulation
Fat oxidation revolution: Stimulate the metabolic rate of brown adipose tissue by 50%, and daily intake of 20 mg can reduce body fat rate by 3.5%;
Neuroprotective potential: Reversibly inhibit acetylcholinesterase, improve cognitive function scores of dementia patients by 30%, and the duration of action is twice that of conventional drugs.
Cross-border discovery: A 2020 study by Southwest University revealed for the first time its fruit and vegetable preservation function – 0.1mmol/L synephrine hydrochloride treatment can inhibit the activity of polyphenol oxidase in litchi peel, delay browning by regulating membrane lipid metabolism, and extend the shelf life to 14 days.
● What Are The Application Of Synephrine Hydrochloride ?
1. Dominant Market In The Pharmaceutical Field
First aid preparations: injections and tablets are used for surgical hypotension and shock.
Chronic disease management: combined with aminophylline to treat bronchial asthma, the acute attack rate is reduced by 60%.
Weight loss drugs: as a natural substitute for ephedrine, it can be used as a sports supplement.
2. Agricultural Preservation Innovation
Lychee browning inhibitor: after the lychee is harvested and treated with synephrine hydrochloride, the total cost is only 1/3 of the traditional cold chain.
Citrus antiseptic coating: nanoemulsion compounded with chitosan, the antibacterial rate is >99%, and the storage period at room temperature is extended by 21 days.
3. Extension Of Functional Consumer Products
Energy drinks: “Synephrine + taurine” functional drinks can improve sports endurance
Neural health food: capsule preparations targeting acetylcholinesterase to improve memory impairment in the elderly.
● Newgreen Supply High Quality Synephrine Hydrochloride Powder
Post time: Jul-18-2025
