●What Is Sodium 3-Hydroxybutyrate ?
Sodium 3-hydroxybutyrate (sodium β-hydroxybutyrate, BHB-Na) is the core substance of human ketone body metabolism. It exists naturally in blood and urine, especially in the state of hunger or low carbohydrate. The traditional preparation is based on the hydrolysis of 3-hydroxybutyric acid esters (methyl ester/ethyl ester) and sodium hydroxide, but it requires organic solvent recrystallization, which leads to complex process, easy moisture absorption and agglomeration of products, and residual solvents may affect the safety of medical applications.
At present, some companies have made breakthroughs in process innovation: the impurities of crotonic acid are controlled below 16ppm by methanol-acetone fractional crystallization method, and the purity is increased to 99.5%, which meets the injection standard;
The one-step crystallization technology of spray drying uses 160℃ hot air to directly convert the reaction liquid into spherical microcrystals, with a product yield of more than 95%. The X-ray diffraction spectrum shows 17 characteristic peaks (2θ=6.1°, 26.0°, etc.), and the stability of the crystal structure is 3 times higher than that of the traditional process, which completely solves the moisture absorption problem.
●What Are The Benefits Of Sodium 3-Hydroxybutyrate ?
As a “super fuel molecule”, sodium 3-hydroxybutyrate directly supplies energy through the blood-brain barrier, and its physiological mechanism has been deeply explored in recent years:
Metabolic Regulation: In a diabetic model, it improves insulin sensitivity. A single dose (0.2 mg/kg) can increase the liver glycogen synthesis rate by 40%;
Neuroprotection: Studies have found that its derivative 3-hydroxybutyrate methyl ester can activate L-type calcium channels, increase the calcium ion concentration in glial cells by 50%, and inhibit cell apoptosis by 35%, providing a new path for the treatment of Alzheimer’s disease;
Anti-Inflammatory And Antioxidant: By reducing lipid peroxides and reactive oxygen species (ROS), it relieves muscle inflammation after exercise, and athletes’ endurance performance improves by 22% after supplementation.
●What Are The Application Of Sodium 3-Hydroxybutyrate ?
1. Health Industry: The Core Carrier Of Ketogenic Economy
Weight management: as the main ingredient of ketogenic supplements, it stimulates the liver’s ketogenic efficiency.
Sports nutrition: electrolyte drinks Sodium 3-Hydroxybutyrate compounded with branched-chain amino acids can maintain blood ketone concentrations above 4mM after exercise and shorten muscle recovery time by 30%.
2. Medical Field: New Hope For Neurodegenerative Diseases
Adjuvant treatment of epilepsy: combined with anticonvulsants can reduce the frequency of seizures by 30%, and phase III clinical trials have been launched;
Targeted delivery system: Cy7 fluorescent labeled probes achieve in vivo tracing, and near-infrared imaging shows that it is enriched in the hippocampus within 2 hours, providing a carrier for brain drug administration.
3. Materials Science: The Biological Key To Cracking White Pollution
Biodegradable plastics: Copolymerized with aromatic polyester to form PHB (poly 3-hydroxybutyrate), with a melting point of 175°C and an oxygen permeability of only 1/10 of PET. It can be completely degraded in anaerobic soil in 60 days. Guangdong Yuanda New Materials Co., Ltd. has achieved industrial-grade mass production;
Disintegrating agricultural film: PE mulch with 5% sodium 3-hydroxybutyrate added, which loses its mechanical properties spontaneously after use, and has no microplastic residues after composting.
●NEWGREEN Supply High Quality Sodium 3-Hydroxybutyrate Powder
Post time: Jul-17-2025
