●What is Hydrolyzed Collagen ?
Hydrolyzed collagen is a product that decomposes natural collagen into small molecule peptides (molecular weight 2000-5000 Da) through enzymatic hydrolysis or acid-base treatment. It is easier to absorb than ordinary collagen. Its core raw materials include:
Animal-based: mainly extracted from bovine Achilles tendon (type I collagen), pig skin (mixed type I/III), fish skin and fish scales (hypoallergenic, type I accounts for 90%). Fish skin has become a hot raw material in recent years because of its high collagen content of 80% and no religious taboos. Traditional mammalian sources have the risk of mad cow disease, and the absorption rate of large molecule collagen is only 20%-30%. It is decomposed into small molecule peptides (2000-5000 Da) through enzymatic hydrolysis technology, and the bioavailability is increased to more than 80%.
Emerging plant sources: humanized collagen expressed by genetically engineered yeast (such as type III recombinant collagen of China Jinbo Bio).
●Common Preparation Processes Of Hydrolyzed Collagen:
1. Enzymatic hydrolysis process
Directed enzymatic cleavage technology: using alkaline protease (such as subtilisin) and flavor protease for synergistic hydrolysis, accurately controlling the molecular weight in the range of 1000-3000 Da, and the peptide yield exceeds 85%.
Three-step innovation: taking albacore tuna skin as an example, first alkali treatment (0.1 mol/L Ca(OH)₂ removal), then heat treatment at 90℃ for 30 minutes, and finally gradient enzymatic hydrolysis, so that the peptide segment with a molecular weight of less than 3kD accounts for 85%.
2. Biosynthesis
Microbial fermentation method: using engineered strains (such as Pichia pastoris) to express human collagen genes to prepare hydrolyzed collagen, the purity can reach more than 99%.
Nanoscale hydrolysis: preparing 500 Da ultramicropeptides using ultrasound-enzyme-linked technology, the transdermal absorption rate is increased by 50%.
●What Are The Benefits Of The Hydrolyzed Collagen ?
1. The “Gold Standard” For Skin Anti-Aging
Clinical data: Oral administration of 10g daily for 6 months increased skin elasticity by 28% and reduced transepidermal water loss by 19%;
Photodamage repair: Inhibition of matrix metalloproteinase MMP-1, UV-induced wrinkle depth reduced by 40%.
2. Intervention Of Joint And Metabolic Diseases
Osteoarthritis: Type II collagen peptide (from chicken sternal cartilage) reduced patients’ WOMAC pain scores by 35%;
Osteoporosis: Postmenopausal women supplemented with 5g of Hydrolyzed Collagen daily for 1 year, bone density increased by 5.6%;
Weight management: Enhanced satiety by activating GLP-1, waist circumference reduced by an average of 3.2cm in 12-week trials.
3. Medical Emergency And Regeneration
Plasma substitutes: Large-dose infusion (>10,000ml) of gelatin-based hydrolyzed collagen preparations does not affect coagulation function and is used for disaster emergency treatment;
Wound repair: Adding collagen peptides to burn dressings shortens healing time by 30%.
●What Are The Applications Of Hydrolyzed Collagen ?
1. Beauty And Personal Care (Accounting For 60%)
Injectable fillers: Recombinant type III collagen (such as Shuangmei and Jinbo Bio) has obtained China’s Class III medical device license, with an annual growth rate of 50%;
Effective skin care:
Peptides with molecular weight less than 1000 Da are used in essences (SkinCeuticals CE Essence) to promote penetration and absorption;
Masks and lotions are compounded with moisturizing factors, and the 48-hour water lock rate is increased by 90%.
2. Functional Food And Medicine
Oral market: Collagen gummies and hydrolyzed collagen oral liquids have global sales of $4.5 billion (2023);
Medical materials: bone and joint repair stents, artificial corneas, and global regenerative medicine applications have increased by 22% annually.
3. Agricultural And Environmental Innovation
Pet nutrition: Many pet health food companies add hydrolyzed collagen to pet food.
Sustainable materials: The EU Bio4MAT project develops biodegradable packaging films to reduce pollution from fishery waste.
●NEWGREEN Supply Hydrolyzed Collagen Powder
Post time: Jun-19-2025
