● What Is Chondroitin Sulfate Sodium ?
Chondroitin Sulfate Sodium (CSS) is a natural acidic mucopolysaccharide with a chemical formula of C₄₂H₅₇N₃Na₆O₄₃S₃X₂ (molecular weight of about 1526.03). It is mainly extracted from cartilage tissues of animals such as pigs, cattle, and sharks. Its molecular structure is composed of alternating D-glucuronic acid and N-acetylgalactosamine, containing 50-70 disaccharide units and carrying equal amounts of acetyl and sulfate groups. The top raw materials still rely on low-temperature fresh cartilage, among which pig laryngeal bones and mid-nasal bones are the first choice for medical-grade extraction due to their high chondroitin sulfate A/C content (accounting for more than 24% of dry weight).
Extraction process of Chondroitin Sulfate Sodium:
Traditional extraction requires four precise processes:
Alkaline deproteinization: Soak cartilage in 2% sodium hydroxide solution and extract with stirring at room temperature
Enzymatic purification: Hydrolyze with pancreatic enzymes at 53-54℃ for 7 hours, and adsorb impurities with activated carbon;
Ethanol precipitation: Adjust pH to 6.0 and add 75% ethanol to precipitate;
Dehydration and drying: Wash with anhydrous ethanol and dry in vacuum at 60-65℃.
Process upgrade: Many companies have launched new medical device-grade raw materials, using shark cartilage for extraction, passing virus inactivation verification and aseptic process, and pyrogen and cytotoxicity tests to meet international standards.
● What Are The Benefits Of Chondroitin Sulfate Sodium ?
1. Core Of Joint Disease Treatment
Cartilage repair: stimulate chondrocytes to synthesize collagen, improve synovial fluid viscoelasticity, and reduce joint friction in osteoarthritis patients by 40%;
Anti-inflammatory analgesia: inhibit phospholipase A2 and matrix metalloproteinases, reduce the production of inflammatory mediators such as prostaglandins, and the pain relief rate reaches 90% after 12 weeks of treatment.
2. Cardiovascular System Regulation
Lipid-lowering and vascular protection: remove lipid deposits on the vascular wall, significantly reduce plasma cholesterol, and reduce the area of atherosclerotic plaques by 60%;
Anticoagulation: The anticoagulant activity of Chondroitin Sulfate Sodium is 0.45 times/mg of heparin, and thrombosis is prevented through the fibrinogen system.
3. Intervention Of Cross-System Diseases
Hearing protection: repair cochlear hair cells, and the effective rate of preventing deafness caused by streptomycin exceeds 85%;
Ophthalmic application: improve corneal water metabolism, and increase the tear secretion of patients with dry eye by 50%;
Anti-tumor potential: shark-derived chondroitin sulfate inhibits the metastasis of cancer cells by blocking tumor angiogenesis.
● What Are The Application Of Chondroitin Sulfate Sodium ?
1. Dominant Market In The Pharmaceutical Field
Joint health care: Combined preparations with glucosamine account for 45% of the global osteoarthritis drug market
Cardiovascular drugs: Daily oral administration of 0.6-1.2g can reduce the mortality rate of coronary heart disease by 30%
2. Medical Devices And Medical Aesthetics Innovation
Ophthalmic viscoelastics: High-purity chondroitin sulfate sodium is used in cataract surgery to protect the survival rate of corneal endothelial cells by more than 95%;
Medical aesthetic fillers: can be used as sterile injection-grade raw materials for water light injections and dermal fillings, and promote collagen regeneration efficiency by 70%;
Wound healing: 0.2% gel accelerates the healing of diabetic foot ulcers, and the wound shrinkage rate in 21 days reaches 80%.
3. Extension Of Functional Consumer Products
Skin care and anti-aging: Adding it to creams can increase the skin moisture content by 16% and reduce the depth of wrinkles by 29%;
Health food: A company launched "CSS+fish oil" functional soft candy to simultaneously regulate joint flexibility and blood lipid levels.
● Newgreen Supply High Quality Chondroitin Sulfate Sodium Powder
Post time: Aug-12-2025
