● What is Chenodeoxycholic Acid ?
Chenodeoxycholic Acid (CDCA) is one of the main components of vertebrate bile, accounting for 30%-40% of human bile acid, and its content is relatively high in the bile of geese, ducks, pigs and other animals.
Breakthroughs in modern extraction technology:
Supercritical CO₂ extraction: extraction under low temperature and high pressure conditions to avoid organic solvent residues, and the purity can reach more than 98%;
Microbial fermentation method: using genetically engineered strains (such as Escherichia coli) to synthesize CDCA, the cost is reduced by 40%, which is in line with the trend of green pharmaceutical manufacturing;
Chemical synthesis method: using cholesterol as a precursor, it is obtained through multi-step reactions, suitable for high-purity pharmaceutical-grade products.
Physical and chemical properties of Chenodeoxycholic Acid :
Chemical name: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Molecular formula: C₂₄H₄₀O₄
Molecular weight: 392.58 g/mol
Appearance: white crystalline powder
Solubility: slightly soluble in water, easily soluble in ethanol, ether, chloroform
Melting point: 165-168℃
Stability: sensitive to light and heat, needs to be refrigerated away from light (2-8℃)
● What are the benefits of the Chenodeoxycholic Acid ?
1. Dissolution Of Cholesterol Gallstones
Mechanism: inhibit liver HMG-CoA reductase, reduce cholesterol synthesis, promote bile acid secretion, and gradually dissolve cholesterol gallstones;
Clinical data: 750mg CDCA per day for 12-24 months, gallstone dissolution rate can reach 40%-70%.
2. Treatment Of Primary Biliary Cholangitis (Pbc)
First-line drugs: FDA approved Chenodeoxycholic Acid CDCA for PBC, improve liver function indicators (ALT/AST reduced by more than 50%);
Combination therapy: combined Chenodeoxycholic Acid with ursodeoxycholic acid (UDCA), the efficacy is improved by 30%.
3. Regulation Of Metabolic Diseases
Lowering blood lipids: lowering serum total cholesterol (TC) and low-density lipoprotein (LDL);
Anti-diabetes: improving insulin sensitivity, animal experiments show that blood sugar drops by 20%
4. Anti-Inflammatory And Immune Regulation
Inhibit the NF-κB pathway and reduce the release of inflammatory factors (TNF-α, IL-6);
Clinical trials have shown that the improvement rate of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) exceeds 60%.
● What Are The Applications Of Chenodeoxycholic Acid ?
1. Medical Field
Gallstone treatment: CDCA tablets (250mg/tablet), daily dose 10-15mg/kg;
PBC treatment: compound preparations with UDCA (such as Ursofalk®), global annual sales exceed US$500 million;
Anti-tumor research: inhibiting liver cancer cell proliferation by regulating FXR receptors, entering Phase II clinical trials.
2. Functional Foods And Health Products
Liver protection tablets: compound formula (CDCA + silymarin), reducing alcoholic liver damage;
Lipid-lowering capsules: synergistic with red yeast rice extract to regulate blood lipid metabolism.
3. Animal Husbandry And Aquaculture
Feed additives: improve livestock and poultry fat metabolism, reduce abdominal fat rate;
Fish health: adding 0.1% chenodeoxycholic acid to enhance carp disease resistance and increase survival rate by 15%.
4. Cosmetics And Personal Care
Anti-inflammatory essence: 0.5%-1% addition, improve acne and skin sensitivity;
Scalp care: inhibit Malassezia and reduce dandruff generation.
From traditional bile extraction to microbial synthesis, chenodeoxycholic acid is undergoing a transformation from a “natural ingredient” to a “precision medicine”. With the deepening of research on metabolic diseases and anti-tumor, CDCA may become the core raw material for liver disease treatment, functional foods and biomaterials, leading a new wave of the 100 billion health industry.
● NEWGREEN Supply Chenodeoxycholic Acid Powder
Post time: Jun-11-2025
