● What is Caffeic Acid ?
Caffeic acid, chemical name 3,4-dihydroxycinnamic acid (molecular formula C₉H₈O₄, CAS No. 331-39-5), is a natural phenolic acid compound widely found in plants. It is yellow crystal in appearance, slightly soluble in cold water, easily soluble in hot water, ethanol and ethyl acetate, with a melting point of 194-213℃ (different processes vary), orange-red in alkaline solution, and dark green in contact with ferric chloride.
Core extraction sources include:
● Medicinal plants: Asteraceae Solidago, cinnamon, dandelion (containing caffeic acid ≥ 0.02%), Ranunculaceae Cimicifuga rhizome;
● Fruit and vegetable resources: lemon peel, blueberry, apple, broccoli and cruciferous vegetables;
● Beverage ingredients: coffee beans (in the form of chlorogenic acid esters), wine (conjugated with tartaric acid).
Modern technology uses supercritical CO₂ extraction or bio-enzymatic hydrolysis technology to purify caffeic acid from plant raw materials, with a purity of more than 98%, meeting pharmaceutical and cosmetic grade standards.
● What Are The Benefits Of Caffeic Acid ?
Caffeic acid exhibits multiple biological activities due to its o-diphenolic hydroxyl structure:
1. Antioxidant And Anti-Inflammatory:
It has the strongest free radical scavenging ability among hydrogenated cinnamic acid, and its efficiency is 4 times that of vitamin E. It blocks lipid peroxidation chain reactions by forming quinone structures;
Inhibits leukotriene synthesis (regulates immunity and inflammation), reduces UV-induced skin DNA damage, and reduces erythema index by 50%.
2. Metabolic And Cardiovascular Protection:
Caffeic acid Inhibits low-density lipoprotein (LDL) oxidation and reduces atherosclerotic plaque formation;
In high-fat diet mouse experiments, visceral fat accumulation decreased by 30% and liver triglycerides decreased by 40%.
3. Neuroprotection And Anti-Tumor:
Enhanced hippocampal insulin signaling, improved memory function in Alzheimer's disease models, and reduced β-amyloid protein deposition;
Inhibits the proliferation of fibrosarcoma cancer cells and inhibits tumor growth by reducing DNA methylation.
4. Hemostasis And Leukocyte Increase:
It shrinks microvessels and improves the function of coagulation factors. It is clinically used for surgical hemostasis and leukopenia after chemotherapy, with an effective rate of over 85%.
● What Are The Applications Of Caffeic Acid ?
The application of caffeic acid covers many fields:
1. Medicine: caffeic acid tablets (hemostasis, white blood cell increase), anti-tumor targeted drugs (succinic acid phase II clinical trial)
2. Cosmetics: sunscreen (synergistic zinc oxide to increase SPF value), whitening essence (inhibit tyrosinase, melanin inhibition rate 80%)
3. Food Industry: natural preservatives (delaying fish lipid oxidation), functional beverages (anti-oxidation and anti-inflammatory), synergistic use of ascorbic acid
4. Agriculture And Environmental Protection: ecological pesticides (inhibit cotton bollworm protease), wool modification (antioxidant properties increased by 75%)
● Usage And Safety Regulations Of Caffeic Acid
Medicinal dosage: Caffeic acid tablets: 0.1-0.3g once, 3 times a day, 14 days as a course of treatment, platelet count needs to be monitored (reduced when >100×10⁹/L, need to consult a doctor before use );
Contraindications: Contraindicated for pregnant women and patients with hypercoagulable state; used with caution in patients with liver dysfunction and gastrointestinal ulcers.
Cosmetic additives: 0.5%-2% added to whitening products, pre-dissolved in ethanol and then added to the aqueous matrix to avoid agglomeration.
Storage requirements: sealed in a dark place, refrigerated at 2-8℃, valid for 2 years (liquid preparations need to be protected from oxidation and degradation)
● NEWGREEN Supply Caffeic Acid Powder
Post time: Jul-23-2025
