• What Is Bifidobacterium Longum ?
Bifidobacterium longum has always held a central position in humanity’s exploration of the relationship between microbes and health. As the most abundant and widely used member of the Bifidobacterium genus, its global market size is projected to exceed US$4.8 billion in 2025, with a compound annual growth rate of 11.3%. A 2025 study published in Nature Microbiology confirmed that Bifidobacterium longum can regulate anxiety behaviors via the gut-brain axis, signaling that this “intestinal native” is reshaping the health industry landscape in a new dimension.
Bifidobacterium longum: Gram-positive, non-spore-forming, and strictly anaerobic, it grows optimally at 36-38°C and tolerates a pH range of 5.5-7.5. Its viable cell density in MRS culture medium can reach 10^10 CFU/mL.
Industrial preparation: Using microencapsulation technology, the viable cell survival rate is increased to 92%.
• What Are The Benefits Of Bifidobacterium Longum ?
Based on over 3,000 global studies, Bifidobacterium longum demonstrates multifaceted biological effects:
1. Gut Health Management
Microbiome Modulation: It suppresses pathogens by secreting antimicrobial peptides (such as bifidocin), increasing the abundance of intestinal bifidobacteria by 3-5 times.
Mucosal Repair: It upregulates occludin protein expression, reduces intestinal permeability (FITC-dextran permeability decreased by 41%), and alleviates leaky gut syndrome
2. Immune Regulation
Cytokine Balance: Bifidobacterium longum stimulates IL-10 secretion (increases concentration by 2.1 times), inhibits TNF-α (decreases by 58%), and improves inflammatory bowel disease.
Allergy Intervention: It reduces serum IgE levels by 37% and reduces the incidence of atopic dermatitis in infants and young children (OR = 0.42).
3. Neuropsychiatric Modulation
Gut-Brain Axis Effects: It activates the vagus nerve pathway, reducing forced swimming immobility time in anxiety-related mice by 53%. Metabolic Intervention: SCFAs (short-chain fatty acids) regulate GABA receptors and improve sleep quality in rats modeling chronic stress.
4. Disease Prevention and Treatment
Metabolic Syndrome: Reduced fasting blood glucose by 1.8 mmol/L in patients with type 2 diabetes and improved the HOMA-IR index by 42%.
Adjuvant Cancer Therapy: Combination with 5-FU increased the survival rate of mice bearing colon cancer by 31% and reduced tumor volume by 54%.
• What Are The Application Of Bifidobacterium Longum ?
Bifidobacterium longum is breaking through traditional boundaries, forming six major application areas:
1. Food Industry
Fermented dairy products: When combined with Streptococcus thermophilus, it increases yogurt viscosity by 2.3 times and extends shelf life to 45 days.
Functional foods: Adding 5×10^9 CFU/g to cereal bars increases bowel movement frequency from 2.1 to 4.3 times per week in people with constipation.
2. Pharmaceuticals
Over-the-counter (OTC) drugs: Bifidobacterium longum triple live bacteria capsules (Lizhu Changle) have annual sales exceeding 230 million boxes and are 89% effective in treating diarrhea.
Biologics: Sublingual fast-dissolving tablets increase probiotic colonization speed by three times and have received FDA Fast Track approval.
3. Agriculture and Feed
Livestock and poultry farming: Adding 1×10^8 CFU/kg of feed reduces diarrhea in piglets by 67% and increases feed conversion by 15%. Plant Protection: Rhizosphere planting reduced tomato bacterial wilt by 42% and increased yield by 18%.
4. Cosmetic Ingredients
Barrier Repair: 0.1% bacterial extract reduced skin TEWL (transepidermal water loss) by 38%, earning EU ECOCERT certification.
Anti-Aging Applications: Combined bifidobacterium longum with peptides, it reduced the depth of periorbital wrinkles by 29%, earning special-use cosmetic certification from the Japanese Ministry of Health, Labour and Welfare.
5. Environmental Technology
Wastewater Treatment: Ammonia nitrogen degradation efficiency of 78% was achieved, reducing sludge production by 35%.
Biofuel: Acetic acid production efficiency increased to 12.3 g/L, reducing costs by 40% compared to traditional processes.
6. Pet Health
Pet Food: Adding 2×10^8 CFU/kg to dog food improved fecal scores by 61% and reduced diarrhea.
Behavior Modification: The spray alleviated separation anxiety and reduced aggressive behavior by 54%.
• Newgreen Supply High Quality Bifidobacterium Longum Powder
Post time: Jul-29-2025
