● What is Andrographis Paniculata Extract ?
Andrographis paniculata, also known as “one-time happiness” and “bitter grass”, is an annual herbaceous plant of the Acanthaceae family. It is native to South Asia such as India and Sri Lanka, and is now widely distributed in humid and hot areas such as Guangdong and Fujian in China. The whole plant tastes extremely bitter, with a square stem, opposite leaves, and a flowering period of August-September. Traditional Chinese medicine uses its effects of clearing heat and detoxifying, cooling blood and reducing swelling to treat colds, fever, dysentery, sores and snake bites. Modern industry extracts active ingredients from stems and leaves through supercritical CO₂ extraction and bio-enzymatic hydrolysis technology to make standardized powders with an andrographolide content of 8%-98%, promoting its upgrade from folk herbal medicine to international raw materials.
The core active ingredients of Andrographis Paniculata Extracts are diterpenoid lactone compounds, accounting for 2%-5%24, mainly including:
- Andrographolide: molecular formula C₂₀H₃₀O₅, accounting for 30%-50%, is the main active substance for antibacterial and anti-inflammatory.
- Dehydroandrographolide: molecular formula C₂₀H₂₈O₄, melting point 204℃, with significant anti-tumor activity.
- 14-Deoxyandrographolide: molecular formula C₂₀H₃₀O₄, with outstanding efficacy against leptospirosis.
- Neoandrographolide: molecular formula C₂₆H₄₀O₈, good water solubility, suitable for oral preparations.
In addition, flavonoids, phenolic acids and volatile oil components synergistically enhance antioxidant and immunomodulatory functions.
● What Are The Benefits Of Andrographis Paniculata Extract ?
1. Immunomodulation And Anti-Infection
Antibacterial and antiviral: Andrographolide has an inhibition rate of over 90% on Staphylococcus aureus and Shigella dysenteriae, and its clinical efficacy in treating bacillary dysentery is comparable to chloramphenicol. Its water extract can reduce the incidence of influenza by 30% and shorten the course of colds by 50%.
Immunoenhancement: By activating macrophages and T lymphocytes, it can increase the level of CD4⁺ lymphocytes in HIV patients (clinical data: 405→501/mm³, p=0.002).
2. Anti-Tumor And Angiogenesis Inhibition
Direct anti-tumor: Dehydroandrographolide can inhibit the growth of W256 transplanted tumors and inhibit cancer cell proliferation in a dose-dependent manner.
Anti-angiogenesis: Andrographolide blocks tumor angiogenesis by downregulating VEGFR2 expression and inhibiting the ERK/p38 signaling pathway, with an IC₅₀ of 100-200μM.
3. Metabolism And Organ Protection
Liver protection and lipid reduction: Andrographolide maintains glutathione levels and reduces malondialdehyde (MDA) in carbon tetrachloride liver injury model by 40%, which is better than silymarin.
Cardiovascular protection: Regulates nitric oxide/endothelin balance, delays atherosclerosis, and reduces blood lipid levels in experimental rabbits.
4. Anti-Inflammatory And Antioxidant
The water extract of the stem has the strongest ability to scavenge free radicals (IC₅₀=4.42μg/mL), which is 4 times more efficient than synthetic antioxidants and is suitable for chronic inflammatory diseases.
● What Are The Applications Of Andrographis Paniculata Extract ?
1. Medicine And Clinical Treatment
Anti-infective drugs: used for bacterial dysentery, pneumonia injection and oral preparations for pharyngitis, with a clinical cure rate of over 85%.
Anti-tumor targeted drugs: Andrographolide derivative “Andrographine” has entered Phase II clinical trials for leukemia and solid tumors.
Chronic disease management: adjuvant treatment of diabetic retinopathy (0.5-2mg/kg/day) and rheumatoid arthritis (1-3mg/kg/day).
2. Animal Husbandry And Green Breeding
Alternative antibiotics: Compound Andrographis paniculata feed additives reduce the diarrhea rate of piglets and increase the survival rate of broilers; adding 4% extract to carp feed, the weight gain rate reaches 155.1%, and the feed conversion rate is optimized to 1.11.
Disease prevention and control: Andrographis paniculata injection treats swine pneumonia and enteritis, with a cure rate of 90% and a mortality rate of 10%.
3. Health Food And Daily Chemicals
Functional food: Andrographis paniculata extract capsules (200mg per day) are launched in the European and American markets for immune regulation and cold prevention.
Skin care products: Add to anti-inflammatory essences and sunscreens to relieve UV damage and redness of sensitive skin.
4. Breakthroughs In Emerging Fields
Anti-angiogenic drugs: The development of targeted preparations for tumors and diabetic retinopathy has become a key direction of synthetic biology.
Pet healthcare: Anti-inflammatory and immunomodulatory supplements for dogs and cats are launched in the North American market, with an annual growth rate of 35%.
● NEWGREEN Supply Andrographis Paniculata Extract Powder
Post time: Jul-18-2025
