● What is β-NAD ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) is a key coenzyme present in all living cells, with a molecular formula of C₂₁H₂₇N₇O₁₄P₂, and a molecular weight of 663.43. As the core carrier of redox reactions, its concentration directly determines the efficiency of cellular energy metabolism and is known as the "cellular energy currency".
Natural distribution characteristics:
Tissue differences: The content in myocardial cells is the highest (about 0.3-0.5 mM), followed by the liver, and the lowest in the skin (decreases by 50% every 20 years with age);
Existence form: including oxidized form (NAD⁺) and reduced form (NADH), and the dynamic balance of the ratio between the two reflects the state of cellular metabolism.
● Radiation Protection of β-NAD.
Increase the survival rate of hematopoietic stem cells after radiation exposure by 3 times, and receive key attention from NASA's space health project.
Preparation source: From biological extraction to synthetic biology revolution
1. Traditional extraction method
Raw materials: yeast cells (content 0.1%-0.3%), animal liver;
Process: ultrasonic crushing → ion exchange chromatography → freeze drying, β-NAD purity ≥ 95%.
2. Enzyme catalytic synthesis (mainstream process)
Substrate: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Advantage: Immobilized enzyme technology can increase the yield of β-NAD to 97%.
3. Synthetic biology (future direction)
Gene-edited Escherichia coli: An engineered strain constructed by ChromaDex, USA, with a fermentation yield of 6 g/L;
Plant cell culture: The tobacco hairy root system realizes the large-scale production of NAD precursor NR.
● What are the benefits of the β-NAD ?
1. Anti-aging core mechanism
Activate Sirtuins: Increase SIRT1/3 activity by 3-5 times, repair DNA damage, and extend yeast lifespan by 31%;
Mitochondrial empowerment: Clinical studies show that people aged 50-70 years old supplement 500 mg NMN daily, and muscle ATP production increases by 25% after 6 weeks.
2. Neuroprotection
Alzheimer's disease: Restoring neuronal NAD⁺ levels can reduce β-amyloid deposition, and cognitive function of mouse models improves by 40%;
Parkinson's disease: β-NAD Protect dopaminergic neurons through PARP1 inhibition.
3. Metabolic disease intervention
Diabetes: Enhance insulin sensitivity, obese mouse experiments show a 30% decrease in blood sugar;
Cardiovascular protection: Improve endothelial function, and reduce the area of atherosclerotic plaques by 50%.
● What Are The Applications Of β-NAD ?
1. Medical field
Anti-aging drugs: Multiple NMN preparations have been certified as orphan drugs by the FDA for mitochondrial myopathy;
Neurodegenerative diseases: NAD⁺ intravenous injection has entered Phase II clinical trials (indications for Alzheimer's disease).
2. Functional foods
Oral supplements: β-NAD as NAD precursor (NR/NMN) capsules have annual sales exceeding $500 million.
Sports nutrition: Improve athletes' endurance, and there are some NAD optimizers on the market to improve sports performance.
3. Cosmetic innovation
Anti-aging essence: 0.1%-1% NAD⁺ complex, tested to reduce wrinkle depth by 37%;
Scalp care: Activate hair follicle stem cells, and add NAD enhancers to anti-hair loss shampoo.
4. Agriculture and scientific research
Animal health: Adding NAD precursors to sow feed increases the number of piglets by 15%;
Biological detection: NAD/NADH ratio is used as a marker of cell metabolic state for early cancer screening.
● NEWGREEN Supply β-NAD Powder
Post time: Jun-17-2025
