Tauroursodeoxycholic acid (TUDCA), dị ka ihe sitere na bile acid eke, aghọwo ihe na-elekwasị anya na ụlọ ọrụ ahụike zuru ụwa ọnụ n'afọ ndị na-adịbeghị anya n'ihi nchebe imeju ya dị mkpa na mmetụta neuroprotection. Na 2023, nha ahịa TUDCA zuru ụwa ọnụ agafeela US $ 350 nde, ana-atụkwa anya iru $ 820 nde na 2030, yana ọnụego uto kwa afọ nke 12.8%. Ọnụ ahịa ahụike dị elu na-achịkwa ahịa ndị Europe na America. Mpaghara Asia-Pacific (karịsịa China na India) na-eduga ụwa n'ọ̀tụ̀tụ̀ uto ka ọrịa imeju na-adịghị ala ala na-abawanye na nkwalite oriri ahụike.
E wezụga nke ahụ, dịka akwụkwọ ikike nke Besty Pharmaceuticals si kwuo, TUDCA nwere ike imeziwanye usoro pathological nke ọrịa dị iche iche nke neurodegenerative site na igbochi apoptosis neuronal na ibelata nrụgide oxidative. Tụkwasị na nke ahụ, ngwa dị omimi nke teknụzụ AI na nyocha na mmepe ọgwụ (dị ka nyocha nke ebumnuche na njikarịcha nnwale ụlọ ọgwụ) emeela ka mgbanwe mgbanwe ahụike nke TUDCA dịkwuo elu, na nha ahịa dị mkpa na-atụ anya ka ọ gafere US $ 1 ijeri n'ime afọ ise sochirinụ.
●Usoro nkwadebe: site na mmịpụta ọdịnala na njikọ akwụkwọ ndụ akwụkwọ ndụ
1. Usoro mmịpụta ọdịnala:A na-ekewa ursodeoxycholic acid (UDCA) na bile bear, wee jikọta ya na taurine iji mepụta.TUDCA. Oke site na ụkpụrụ nchebe anụmanụ na ikike mmepụta, ọnụ ahịa dị elu ma jiri nwayọọ nwayọọ dochie ya.
2. Usoro njikọ kemịkalụ:N'iji bile acid dị ka akụrụngwa, UDCA na-emepụta site na oxidation, mbelata, condensation na usoro ndị ọzọ, wee megharịa ya. Ịdị ọcha nwere ike iru karịa 99%, mana usoro ahụ dị mgbagwoju anya na mmetọ dị ukwuu.
3. Usoro ịgba ụka Microbial (Ntụziaka ihu):Iji Escherichia coli ma ọ bụ yist mebere site na mkpụrụ ndụ ihe nketa iji megharịa ozugboTUDCA, ọ nwere uru nke akwụkwọ ndụ akwụkwọ ndụ, obere carbon na nnukwu mmepụta ikike. Na 2023, ụlọ ọrụ BioCore dị na South Korea enwetala mmepụta pilot, na-ebelata ọnụ ahịa site na 40%.
4. Enzyme catalysis usoro:Teknụzụ enzyme na-adịghị ahụkebe nwere ike ime ka njikọ nke UDCA na taurine rụọ ọrụ nke ọma, yana ọnọdụ mmeghachi omume dị nro, nke dabara maka mmepụta ọkwa ọgwụ.
●Uru: Usoro ihe nleba anya ọtụtụ, na-ekpuchi ọtụtụ ebe ọrịa
Usoro bụ isi nke TUDCA bụ iji mee ka akpụkpọ ahụ dịkwuo mma, na-egbochi nrụgide endoplasmic reticulum na ụzọ akara apoptosis, na akwadoro ụlọ ọgwụ n'ọtụtụ ọnọdụ:
1. Ọrịa ịba ọcha n'anya:
⩥ Ọgwụgwọ nke isi biliary cholangitis (PBC), ọrịa imeju na-adịghị egbu egbu (NAFLD), na mbelata ihe ngosi ALT/AST.
⩥ na-ebelata cholestasis ma kwalite metabolism nke bilirubin. FDA akwadola ọkwa ọgwụ nwa mgbei ya.
2. Nchekwa Neuro:
⩥ Melite mmebi akwara ozi na ọrịa Alzheimer na ọrịa Parkinson. Nnyocha okike 2022 gosiri na ọ nwere ike ibelata ntinye β-amyloid.
⩥ Gosipụtara ike igbu oge ọrịa na nnwale ụlọ ọgwụ nke amyotrophic lateral sclerosis (ALS).
3. Metabolism na mgbochi ịka nká:
⩥ Na-ahazi mmetụta insulin ma nyere aka na njikwa ọrịa shuga.
⩥ Mee ka ọrụ mitochondrial rụọ ọrụ, gbatịa ndụ nke ihe nlere anya, wee bụrụ onye na-achọ ihe maka "ọgwụ ogologo ndụ".
4. Ngwa anya:
⩥ Ọ nwere mmetụta nchebe na retinitis pigmentosa na glaucoma, na ọdịda anya metụtara abanyela ule ụlọ ọgwụ na-agba nke Atọ.
●TUDCA mpaghara ngwa: site na ọgwụ na nri na-arụ ọrụ
1. Ngalaba ahụike:
⩥ Ọgwụ ndenye ọgwụ: TUDCA eji maka PBC, mgbasa gallstone (dị ka nkwadebe European Taurursodiol).
⩥ Mmepe ọgwụ mgbei: ọgwụgwọ ngwakọta maka ọrịa ndị na-adịghị ahụkebe dị ka spinal muscular atrophy (SMA).
2. Ngwaahịa ahụike:
⩥ Mbadamba ụrọ nchebe imeju, ngwaahịa na-egbu egbu: TUDCAenwere ike ijina silymarin na curcumin iji kwalite mmetụta ahụ.
⩥ Capsules mgbochi ịka nká: jikọtara ya na NMN na resveratrol, na-elekwasị anya na nrụzi mitochondrial.
3. Nri egwuregwu:
⩥ Mbelata mbufụt nke anụ ahụ mgbe ọzụzụ dị elu, ejiri ya dị ka mgbakwunye mgbake site n'aka ndị ọkachamara na-eme egwuregwu.
4. Ahụike anụ ụlọ:
⩥ Ọgwụgwọ na nlekọta ahụike nke ọrịa imeju na gallbladder na nkịta na nwamba, ngwaahịa ndị metụtara ya na ahịa US ga-eto site na 35% na 2023.
Site na ọnụ ọgụgụ na-arịwanye elu nke ịka nká na ọnụ ọgụgụ dị elu nke ọrịa metabolic, uru nke TUDCA na ngalaba ọgwụ, nlekọta ahụike, na mgbochi ịka nká ga-ahapụ ọzọ. Teknụzụ bayoloji sịntetik nwere ike ịkwalite ọnụ ahịa dị ọnụ ala ma mepee ahịa ahụike ruru ọtụtụ narị ijeri yuan.
●Nweta ỌhụrụTUDCANtụ ntụ
Oge nzipu: Eprel-15-2025
