Tauroursodeoxycholic acid (TUDCA), raws li ib tug derivative ntawm natural bile acid, tau dhau los ua lub hom phiaj ntawm lub ntiaj teb no kev noj qab haus huv kev lag luam nyob rau hauv xyoo tas los no vim nws lub siab tseem ceeb tiv thaiv thiab neuroprotection cuam tshuam. Hauv 2023, lub ntiaj teb TUDCA kev lag luam loj tau tshaj US $ 350 lab, thiab xav tias yuav ncav cuag US $ 820 lab hauv 2030, nrog kev loj hlob txhua xyoo ntawm 12.8%. Cov lag luam nyob sab Europe thiab Asmeskas yog cov thawj coj los ntawm kev nkag mus siab ntawm cov khoom noj qab haus huv. Cov cheeb tsam Asia-Pacific (tshwj xeeb yog Tuam Tshoj thiab Is Nrias teb) ua rau lub ntiaj teb nyob rau hauv kev loj hlob raws li qhov tshwm sim ntawm cov kab mob siab ntev nce thiab kev noj qab haus huv hloov pauv.
Tsis tas li ntawd, raws li patents tuav los ntawm Besty Pharmaceuticals, TUDCA tuaj yeem txhim kho cov txheej txheem pathological ntawm ntau yam kab mob neurodegenerative los ntawm inhibiting neuronal apoptosis thiab txo oxidative kev nyuaj siab. Tsis tas li ntawd, qhov kev siv tob tob ntawm AI thev naus laus zis hauv kev tshawb fawb tshuaj thiab kev tsim kho (xws li lub hom phiaj kev tshuaj ntsuam xyuas thiab kev sim tshuaj ntsuam xyuas kom zoo) tau ua kom cov kev hloov pauv hloov pauv ntawm TUDCA, thiab cov lag luam cuam tshuam loj yuav tsum tshaj US $ 1 nphom hauv tsib xyoos tom ntej.
●Txoj kev npaj: los ntawm tsoos extraction mus rau ntsuab synthesis
1. Txoj kev rho tawm ib txwm:ursodeoxycholic acid (UDCA) yog cais los ntawm dais bile, thiab tom qab ntawd ua ke nrog taurine los tsimTUDCA. Kev txwv los ntawm kev tiv thaiv tsiaj txhu thiab kev tsim khoom muaj peev xwm, tus nqi yog siab thiab nws maj mam hloov.
2. Tshuaj Synthesis Method:Siv cov kua tsib kua qaub ua raw khoom, UDCA yog synthesized los ntawm oxidation, txo, condensation thiab lwm cov kauj ruam, thiab ces taurized. Lub purity tuaj yeem ncav cuag ntau dua 99%, tab sis cov txheej txheem nyuaj thiab cov pa phem loj.
3. Microbial Fermentation Method (Frontier Direction):Siv genetic engineered Escherichia coli los yog poov xab kom ncaj qha synthesizeTUDCA, nws muaj qhov zoo ntawm ntsuab, qis-carbon thiab loj loj ntau lawm peev xwm. Xyoo 2023, BioCore Tuam Txhab hauv Kaus Lim Qab Teb tau ua tiav kev tsim khoom, txo cov nqi los ntawm 40%.
4. Enzyme Catalysis Method:Immobilized enzyme thev naus laus zis tuaj yeem ua kom muaj txiaj ntsig zoo rau kev sib xyaw ntawm UDCA thiab taurine, thiab cov tshuaj tiv thaiv me me, uas tsim nyog rau kev tsim tshuaj-qib.
●Cov txiaj ntsig: Ntau lub hom phiaj ntawm kev ua haujlwm, suav nrog ntau yam kab mob
Cov txheej txheem tseem ceeb ntawm TUDCA yog txhawm rau txhim kho cov cell membrane, inhibit endoplasmic reticulum stress thiab apoptosis signaling pathways, thiab tau raug kuaj xyuas hauv ntau qhov xwm txheej:
1. Cov Kab Mob Hepatobiliary:
⩥ Kev kho tus kab mob biliary cholangitis (PBC), cov kab mob uas tsis yog-alcoholic fatty siab (NAFLD), thiab txo cov ntsuas ALT/AST.
⩥ Relieve cholestasis thiab txhawb cov metabolism hauv bilirubin. FDA tau pom zoo nws cov tshuaj me nyuam ntsuag.
2. Neuroprotection:
⩥ Txhim kho neuronal puas hauv Alzheimer's disease thiab Parkinson's disease. Ib txoj kev tshawb fawb 2022 Nature tau pom tias nws tuaj yeem txo qis β-amyloid deposition.
⩥ Qhia tau tias muaj peev xwm ncua sijhawm ntawm cov kab mob hauv kev sim tshuaj ntawm amyotrophic lateral sclerosis (ALS).
3. Metabolism Thiab Anti-aging:
⩥ Tswj cov tshuaj insulin rhiab heev thiab pab tswj ntshav qab zib.
⩥ Ua kom muaj nuj nqi mitochondrial, txuas ntxiv lub neej ntawm cov qauv kab mob, thiab dhau los ua cov khoom sib tw rau "cov tshuaj ua kom ntev".
4. Kev siv Ophhalmic:
⩥ Nws muaj kev tiv thaiv ntawm retinitis pigmentosa thiab glaucoma, thiab cov tshuaj tiv thaiv qhov muag tau nkag mus rau theem III kev sim tshuaj.
●TUDCA daim ntawv thov thaj chaw: los ntawm tshuaj mus rau cov khoom noj khoom haus
1. Kev Kho Mob Field:
⩥ Tshuaj: TUDCA siv rau PBC, gallstone dissolution (xws li European Taurursodiol npaj).
⩥ Kev tsim kho tshuaj Orphan: kev sib xyaw ua ke rau cov kab mob tsis tshua muaj xws li txha nraub qaum muscular atrophy (SMA).
2. Khoom noj khoom haus:
⩥ Cov ntsiav tshuaj tiv thaiv daim siab, cov khoom hangover: TUDCAtuaj yeem siv taunrog silymarin thiab curcumin los txhim kho cov nyhuv.
⩥ Anti-aging capsules: compounded nrog NMN thiab resveratrol, tsom rau kev kho mitochondrial.
3. Kev Noj Qab Haus Huv Kev Ua Si:
⩥ Txo cov nqaij ntshiv tom qab siv kev cob qhia siab, siv los ua kev rov qab los ntawm cov kws ncaws pob kws tshaj lij.
4. Pet Health:
⩥ Kev kho mob thiab kev kho mob ntawm daim siab thiab gallbladder kab mob hauv cov dev thiab miv, cov khoom muaj feem xyuam hauv Asmeskas kev lag luam yuav loj hlob 35% hauv 2023.
Nrog rau cov neeg laus zuj zus tuaj thiab qhov tshwm sim ntawm cov kab mob metabolic siab, tus nqi ntawm TUDCA hauv kev kho mob, kev kho mob, thiab kev tiv thaiv kev laus yuav raug tso tawm ntxiv. Synthetic biology thev naus laus zis tuaj yeem txhawb nqa tus nqi pheej yig thiab qhib kev lag luam kev noj qab haus huv muaj nqis ntau pua lab nyiaj yuan.
● TSHIABGREEN SupplyTUDCAHmoov
Lub sij hawm xa tuaj: Plaub Hlis-15-2025
