Gymnema Sylvestre Extract: Ib qho kev qhuab qhia hla dhau los ntawm cov tshuaj ntsuab hypoglycemic rau lub hnub qub tshiab hauv kev tiv thaiv neuroprotection

●Dab tsi yog Gymnema Sylvestre Extract?

Gymnema sylvestre yog ib tsob ntoo ntawm tsev neeg Apocynaceae, dav faib nyob rau hauv subtropical thaj tsam xws li Guangxi thiab Yunnan hauv Suav teb. Kev siv tshuaj ntsuab yog siv rau hauv nws cov nplooj, uas yog siv los txo cov ntshav qab zib, tiv thaiv cov hniav lwj thiab tiv thaiv cov tsos mob qab zib. Txawm li cas los xij, cov kev tshawb fawb tsis ntev los no tau pom tias nws cov peev txheej qia kuj tseem muaj cov khoom xyaw nquag, thiab cov peev txheej muaj ntau dua 10 npaug ntawm nplooj. Los ntawm txoj kev sib cais cov kuab tshuaj, cov n-butanol thiab 95% ethanol qhov chaw ntawm cov qia extracts pom zoo li UV spectra thiab nyias-txheej chromatography cov yam ntxwv rau nplooj, qhia tau hais tias cov khoom xyaw nquag ntawm ob qhov zoo ib yam. Qhov kev tshawb pom no muab kev txhawb nqa tseem ceeb rau kev nthuav dav cov peev txheej tshuaj thiab txo cov nqi tsim kho.

Cov tshuaj muaj pes tsawg leeg ntawmGymnema sylvestre rho tawmyog complex thiab ntau haiv neeg, feem ntau suav nrog:

Cyclols thiab steroids:Conduritol A, raws li lub hauv paus hypoglycemic tivthaiv, tuaj yeem txhawb glycogen synthesis; stigmasterol thiab nws cov glucoside muaj cov tshuaj tiv thaiv kab mob;

Saponin compounds:Xyoo 2020, yim tshiab C21 steroidal saponins (gymylvestrosides AH) raug cais tawm thawj zaug, thiab lawv cov qauv muaj glucuronic acid thiab rhamnose units, muab lawv cov kev ua lom lom lom zem;

Synergistic Cheebtsam:Cov saw ntev alkanols xws li lupine cinnamyl ester thiab n-heptadecanol txhim kho antioxidant muaj peev xwm los ntawm kev tshem tawm cov dawb radicals.

Nws yog ib qho tsim nyog sau cia tias purity ntawm qia saponins tuaj yeem ncav cuag ntau dua 90%, thiab kev ua kom huv loj tuaj yeem ua tiav los ntawm ethanol recrystallization thev naus laus zis, zam kev siv cov kuab tshuaj lom xws li chloroform.

●Dab tsi yog CovCov txiaj ntsigNtawm Gymnema Sylvestre Extract?

1. Kev tswj ntshav qab zib

Cov kev tshawb fawb kws tshuaj tau pom tias cov qia ethanol tuaj yeem txo cov ntshav qab zib los ntawm 30% -40% hauv alloxan ntshav qab zib nas, thiab cov txheej txheem ntawm kev txiav txim qhia ntau txoj hauv kev sib koom ua ke:

Kev tiv thaiv Islet: kho cov kab mob β puas thiab ua kom cov tshuaj insulin tso tawm;

Kev tswj hwm cov piam thaj hauv cov metabolism: txhawb lub siab glycogen synthesis thiab inhibit plab hnyuv α-glucosidase kev ua haujlwm (txawm hais tias qhov inhibition ntawm monomer saponin tsuas yog 4.9% -9.5%, cov nyhuv synergistic ntawm tag nrho cov extract yog qhov tseem ceeb);

Kev cuam tshuam oxidative kev ntxhov siab: txo cov qib lipid peroxide thiab ua kom muaj zog superoxide dismutase.

2. Neuroprotection

Ib txoj kev tshawb fawb luam tawm hauv Kev Tshaj Tawm Txog Kev Tshawb Fawb hauv 2025 tau qhia txog lub peev xwm ntawmGymnema sylvestrerho tawmhauv kev kho mob Alzheimer's disease (AD):

Targeting tseem ceeb AD proteins: metabolites S-adenosylmethionine thiab bamipine muaj siab affinity nrog β-secretase (BACE1) thiab monoamine oxidase B (MAO-B), txo β-amyloid deposition;

Neural txoj kev tswj hwm: los ntawm kev ua kom lub cAMP/PI3K-Akt signaling pathway, nce choline acetyltransferase (ChaT) qhia, thaum txo cov kev ua ntawm acetylcholinesterase, thiab txhim kho synaptic kis tau tus mob;

Kev kuaj xyuas ntawm tes: Hauv Aβ42-induced neural cell qauv, cov extract txo cov cim ntawm reactive oxygen hom (ROS) los ntawm 40% thiab tus nqi apoptosis ntau dua 50%.

● Dab tsi yog CovDaim ntawv thovOf Gymnema Sylvestre Extract ?

Kev tsim kho tshuaj: Guangxi Guilin Jiqi Lub Tuam Txhab tau siv tag nrho saponins ntawm Gymnema sylvestre (purity 98.2%) rau kev txhim kho ntshav qab zib npaj1; pab neeg tshawb fawb Indian tab tom ua rau kev sim ua ntej ntawm nws cov tshuaj tiv thaiv neuroprotective;

Khoom noj khoom haus noj qab haus huv: nplooj extracts yog siv los ua ntuj sweetness inhibitors rau cov zaub mov tsis muaj suab thaj; qia ethanol extracts yog tsim los ua dej haus rau kev tswj cov ntshav qab zib;

Agricultural applications: low-purity crude extracts are use as plant-based insecticides, targeting the paj hlwb arthropods and have degradable properties.

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