Tauroursodeoxycholic Acid (TUDCA), ma ke ʻano he derivative o ka bile acid maoli, ua lilo ia i mea koʻikoʻi o ka ʻoihana olakino honua i nā makahiki i hala iho nei ma muli o kāna pale nui o ka ate a me nā hopena neuroprotection. I ka makahiki 2023, ua ʻoi aku ka nui o ka mākeke TUDCA honua ma mua o US $ 350 miliona, a ua manaʻo ʻia e hōʻea i ka US $ 820 miliona ma 2030, me ka nui o ka ulu ʻana o ka makahiki he 12.8%. ʻO nā mākeke ʻEulopa a me ʻAmelika e hoʻomalu ʻia e ka helu kiʻekiʻe o ke komo ʻana o nā huahana olakino. ʻO ka ʻāina ʻo Asia-Pacific (ʻoi aku ʻo Kina a me India) ke alakaʻi nei i ka honua i ka ulu ʻana o ka ulu ʻana e like me ka piʻi ʻana o ka maʻi ate maʻi a me ka hoʻonui ʻana i ka ʻai.
Ma waho aʻe, e like me nā patent i mālama ʻia e Besty Pharmaceuticals, hiki i ka TUDCA ke hoʻomaikaʻi nui i ke kaʻina pathological o nā maʻi neurodegenerative like ʻole ma ke kāohi ʻana i ka apoptosis neuronal a me ka hōʻemi ʻana i ke kaumaha oxidative. Eia kekahi, ʻo ka noi hohonu ʻana o ka ʻenehana AI i ka noiʻi a me ka hoʻomohala ʻana i ka lāʻau lapaʻau (e like me ka screening target a me ka hoʻāʻo hoʻāʻo hoʻokolohua) ua hoʻolalelale i ka pono o ka hoʻololi ʻana i ke kino o TUDCA, a ʻo ka nui o ka mākeke kūpono e manaʻo ʻia e ʻoi aku ma mua o US $ 1 biliona i nā makahiki ʻelima e hiki mai ana.
●Kaʻina hoʻomākaukau: mai ka unuhi kuʻuna i ka synthesis ʻōmaʻomaʻo
1. Keʻano unuhi kuʻuna:Hoʻokaʻawale ʻia ka ursodeoxycholic acid (UDCA) mai ka bea bile, a laila hui pū ʻia me ka taurine e hana ai.TUDCA. Ua kaupalena ʻia e nā loina mālama holoholona a me ka hiki ke hana, kiʻekiʻe ke kumu kūʻai a hoʻololi mālie ʻia.
2. Ke Kaʻina Hana Hana Kemika:Ke hoʻohana nei i ka waikawa bile ma ke ʻano he maka, hoʻohui ʻia ʻo UDCA ma o ka oxidation, hōʻemi, condensation a me nā ʻanuʻu ʻē aʻe, a laila hoʻohui ʻia. Hiki i ka maʻemaʻe ke piʻi ma mua o 99%, akā paʻakikī ke kaʻina hana a nui ka pollution.
3. Ke ʻano hoʻoheheʻe ʻana i ka microbial (ke kuhikuhi mua):Ke hoʻohana nei i ka genetically engineered Escherichia coli a i ʻole ka hū no ka synthesize pololeiTUDCA, loaʻa iā ia nā mea maikaʻi o ka ʻōmaʻomaʻo, haʻahaʻa-carbon a me ka hiki ke hana nui. I ka makahiki 2023, ua hoʻokō ʻo BioCore Company ma South Korea i ka hana pilote, e hōʻemi ana i nā kumukūʻai e 40%.
4. ʻO ka Enzyme Catalysis Method:Hiki i ka ʻenehana enzyme Immobilized ke hoʻoikaika maikaʻi i ka hui pū ʻana o UDCA a me ka taurine, a maʻalahi nā ʻano hopena, kūpono ia no ka hana lāʻau lapaʻau.
●Pōmaikaʻi: Multi-target mechanism of action, e uhi ana i kahi ākea o nā wahi maʻi
ʻO ke ʻano kumu nui o TUDCA ʻo ia ka hoʻopaʻa ʻana i ka membrane cell, kaohi ʻana i ke koʻikoʻi endoplasmic reticulum a me nā ala hōʻailona apoptosis, a ua hōʻoia ʻia i ke kauka i nā hihia he nui:
1. Nā maʻi hepatobiliary:
⩥ ʻO ka mālama ʻana i ka cholangitis biliary mua (PBC), ka maʻi momona momona ʻole (NAFLD), a me ka hōʻemi ʻana i nā hōʻailona ALT/AST.
⩥ Hoʻopau i ka cholestasis a hoʻoikaika i ka metabolism bilirubin. Ua ʻae ka FDA i kona kūlana lāʻau makua ʻole.
2. Neuroprotection:
⩥ Hoʻonui i ka pōʻino neuronal i ka maʻi o Alzheimer a me ka maʻi Parkinson. Ua hōʻike ʻia kahi haʻawina 2022 Nature hiki iā ia ke hōʻemi i ka waiho ʻana o β-amyloid.
⩥ Hōʻike i ka hiki ke hoʻopaneʻe i ke ala o ka maʻi ma nā hoʻokolohua lapaʻau o ka amyotrophic lateral sclerosis (ALS).
3. Metabolism a me ka Anti-Aging:
⩥ Hoʻoponopono i ka naʻau o ka insulin a kōkua i ka hoʻokele diabetes.
⩥ E ho'ā i ka hana mitochondrial, e hoʻolōʻihi i ke ola o nā mea ola hoʻohālike, a lilo i mea koho no nā "lāʻau ola lōʻihi".
4. Nā polokalamu Ophthalmic:
⩥ He hopena pale ia i ka retinitis pigmentosa a me ka glaucoma, a ua komo nā kulu maka pili i ka Phase III i nā hoʻokolohua lapaʻau.
●TUDCA nā wahi noi: mai ka lāʻau lapaʻau i ka meaʻai hana
1. Kahua Lapaʻau:
⩥ ʻO nā lāʻau lapaʻau: TUDCA i hoʻohana ʻia no ka PBC, ka hoʻoheheʻe ʻia ʻana o nā pōhaku (e like me ka hoʻomākaukau ʻana o European Taurursodiol).
⩥ ʻO ka hoʻomohala ʻana i ka lāʻau keiki makua ʻole: ka hui ʻana o ka lāʻau lapaʻau no nā maʻi kakaʻikahi e like me ka spinal muscular atrophy (SMA).
2. Nā huahana ola kino:
⩥ Nā papa pale ate, nā huahana hangover: TUDCAhiki ke hoʻohaname ka silymarin a me ka curcumin e hoʻonui i ka hopena.
⩥ Nā capsules anti-aging: hui pū ʻia me NMN a me resveratrol, e kālele ana i ka hoʻoponopono mitochondrial.
3. Nā meaʻai haʻuki:
⩥ Hoʻemi i ka ʻāʻī o ka ʻiʻo ma hope o ka hoʻomaʻamaʻa kiʻekiʻe, hoʻohana ʻia ma ke ʻano he mea hoʻihoʻi hou e nā mea haʻuki ʻoihana.
4. Ola Ola holoholona:
⩥ ʻO ka mālama ʻana a me ka mālama olakino o nā maʻi ate a me ka gallbladder i nā ʻīlio a me nā pōpoki, nā huahana pili i ka mākeke US e ulu e 35% i 2023.
Me ka piʻi ʻana o ka heluna kanaka ʻelemakule a me ka nui o nā maʻi metabolic, e hoʻokuʻu hou ʻia ka waiwai o TUDCA i nā lāʻau lapaʻau, mālama olakino, a me ka anti-aging. Hiki i ka ʻenehana biology Synthetic ke hoʻolaha i nā kumukūʻai kūpono a wehe i kahi mākeke olakino e kūʻai ana i nā haneli he mau piliona yuan.
●NEWGREEN lakoTUDCAPauda
Ka manawa hoʻouna: Apr-15-2025
