ʻO Gymnema Sylvestre Extract: He hōʻailona hoʻopaʻapaʻa mai kahi lāʻau hypoglycemic kuʻuna i kahi hōkū hou i ka neuroprotection

●He aha ʻO Gymnema Sylvestre Extract?

ʻO Gymnema sylvestre kahi kumu waina o ka ʻohana Apocynaceae, i laha nui ʻia ma nā wahi subtropical e like me Guangxi a me Yunnan ma Kina. Hoʻohana ʻia nā lāʻau lapaʻau kuʻuna ma luna o kāna mau lau, i hoʻohana ʻia e hoʻohaʻahaʻa i ke kō koko, pale i ka pala o ka niho a keʻakeʻa i nā hopena ʻono. Eia nō naʻe, ua ʻike ʻia nā haʻawina hou i ka waiwai o kāna kumu kumu i nā mea hana, a ʻoi aku ka nui o nā waihona ma mua o 10 mau manawa o nā lau. Ma o ke kaʻina hoʻokaʻawale hoʻokaʻawale ʻōnaehana, ua hōʻike ʻia nā ʻāpana n-butanol a me 95% ethanol o nā ʻāpana kumu i nā hiʻohiʻona UV like ʻole a me nā hiʻohiʻona chromatography thin-layer i nā lau, e hōʻike ana he kūlike loa nā mea hana o nā mea ʻelua. Hāʻawi kēia ʻike i ke kākoʻo koʻikoʻi no ka hoʻonui ʻana i nā kumu lāʻau lapaʻau a me ka hōʻemi ʻana i nā kumukūʻai hoʻomohala.

ʻO ka hui kemika oʻO Gymnema sylvestre unuhipaʻakikī a ʻokoʻa, ʻo ia hoʻi:

Cyclols a me nā steroids:ʻO Conduritol A, ma ke ʻano he ʻāpana hypoglycemic koʻikoʻi, hiki ke hāpai i ka synthesis glycogen; ʻO ka stigmasterol a me kāna glucoside he hopena hoʻoponopono anti-inflammatory;

ʻO nā hui Saponin:Ma 2020, ʻewalu C21 steroidal saponins (gymsylvestrosides AH) i hoʻokaʻawale ʻia no ka manawa mua, a ʻo kā lākou mau hale i loaʻa i ka glucuronic acid a me ka rhamnose units, e hāʻawi ana iā lākou i ka hana biological kūʻokoʻa;

Nā ʻāpana synergistic:ʻO nā alkanol kaulahao lōʻihi e like me ka lupine cinnamyl ester a me ka n-heptadecanol e hoʻoikaika i ka mana antioxidant ma o ka ʻohi ʻana i nā radical manuahi.

He mea pono e hoʻomaopopo i ka maʻemaʻe o ka saponins stem hiki ke piʻi aku ma mua o 90%, a hiki ke hoʻokō ʻia ka hoʻomaʻemaʻe nui ma o ka ʻenehana recrystallization ethanol, e pale aku i ka hoʻohana ʻana i nā mea ʻawaʻawa e like me ka chloroform.

●He aha kaNā pōmaikaʻiNo ʻO Gymnema Sylvestre Extract?

1. Hooponopono ma'i diabetes

Ua hōʻike ʻia nā haʻawina lāʻau lapaʻau e hiki ke hoʻemi i ka pae koko ethanol e 30%-40% i nā ʻiole diabetic alloxan, a ʻo ke ʻano o ka hana e hōʻike ana i ka synergy multi-pathway:

Palekana moku: hoʻoponopono i nā pūnaewele β i pōʻino a hoʻonui i ka huna ʻana o ka insulin;

ʻO ka hoʻoponopono glucose metabolism: hoʻoikaika i ka synthesis glycogen ate a keʻakeʻa i ka hana α-glucosidase intestinal (ʻoiai he 4.9% -9.5% wale nō ka hopena inhibition o ka monomer saponin, he mea nui ka hopena synergistic o ka extract holoʻokoʻa);

ʻO ke koʻikoʻi koʻikoʻi: hoʻemi i ka pae lipid peroxide a hoʻonui i ka hana superoxide dismutase.

2. Neuroprotection

Ua hōʻike ʻia kahi haʻawina i paʻi ʻia ma Scientific Reports ma 2025 i ka hiki oʻO Gymnema sylvestreunuhii ka mālama ʻana i ka maʻi o Alzheimer (AD):

Ke kuhi nei i nā proteins AD kiʻekiʻe: nā metabolites S-adenosylmethionine a me ka bamipine he pilina paʻa kiʻekiʻe me ka β-secretase (BACE1) a me ka monoamine oxidase B (MAO-B), e hōʻemi ana i ka deposition β-amyloid;

Hoʻoponopono i ke ala neural: ma ka hoʻonāʻana i ke ala hōʻailona cAMP / PI3K-Akt, hoʻonui i ka'ōlelo choline acetyltransferase (ChAT), me ka ho'ēmiʻana i ka hana acetylcholinesterase, a me ka hoʻomaikaʻiʻana i ka synaptic transmission;

Ka hōʻoia ʻana o ka hoʻokolohua kelepona: Ma ka Aβ42-induced neural cell model, ua hoʻemi ka extract i ka hanauna o nā ʻano oxygen reactive (ROS) e 40% a me ka helu apoptosis ma mua o 50%.

● He aha kaPalapala noiOf ʻO Gymnema Sylvestre Extract ?

Hoʻomohala lāʻau lapaʻau: Ua hoʻohana ʻo Guangxi Guilin Jiqi Company i nā saponins piha o Gymnema sylvestre (maʻemaʻe 98.2%) no ka hoʻomohala ʻana i ka hoʻomākaukau ʻana i ka maʻi diabetes1; ke holomua nei ka hui noiʻi India i nā hoʻokolohua preclinical o kāna mau neuroprotective extracts;

ʻAʻai olakino: hoʻohana ʻia nā ʻāpana lau ma ke ʻano he mea hoʻopale ʻono kūlohelohe no nā meaʻai ʻole ke kō; Hoʻokumu ʻia nā ʻāpana ethanol e like me nā mea inu hana no ka hoʻoponopono ʻana i ke kō koko;

Nā noi mahiʻai: hoʻohana ʻia nā ʻāpana ʻōpala haʻahaʻa maʻemaʻe ma ke ʻano he insecticides ma muli o nā mea kanu, e kuhikuhi ana i ka ʻōnaehana nerve o nā arthropods a me nā waiwai degradable.

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