I-Thiamine hydrochloride: Izinzuzo, Ukusetshenziswa nokunye

● IyiniI-Thiamine Hydrochloride ?

I-Thiamine hydrochloride iwuhlobo lwe-hydrochloride kavithamini B₁, enefomula yamakhemikhali ethi C₁₂H₁₇ClN₄OS·HCl, isisindo semolekyuli 337.27, kanye nenombolo ye-CAS 67-03-8. Kuyimpushana ecwebezelayo emhlophe kuya kokumhlophe ukuya kokumhlophe enephunga lebran yerayisi elithambile kanye nokunambitheka okubabayo. Kulula ukumunca umswakama esimweni esomile (kungakwazi ukumunca umswakama ongu-4% uma kuvezwe emoyeni). Izakhiwo eziyinhloko zomzimba namakhemikhali zihlanganisa:

Ukunyibilika:Incibilika kakhulu emanzini (1g/mL), incibilika kancane ku-ethanol ne-glycerol, futhi ayincibiliki kuzincibilikisi zemvelo njenge-ether ne-benzene. 

Ukuzinza:Izinzile endaweni ene-acidic (pH 2-4) futhi ingamelana namazinga okushisa aphezulu angu-140 ° C; kodwa ibola ngokushesha ezixazululweni ezingathathi hlangothi noma ezine-alkaline futhi ivalwa kalula ngemisebe ye-ultraviolet noma ama-redox agents.

Izici zokutholwa:Ihlangana ne-cyanide evundile ukuze ikhiqize into ekhanyayo eluhlaza okwesibhakabhaka “thiochrome”, okuba yisisekelo sokuhlaziywa komthamo38.

Inqubo yokulungiselela eyinhloko emhlabeni wonke iwukuhlanganisa kwamakhemikhali, esebenzisa i-acrylonitrile noma i-β-ethoxyethyl propionate njengezinto zokusetshenziswa futhi ikhiqizwa ngokufingqa, ukujikeleza ngebhayisikili, ukushintshwa nezinye izinyathelo, ngobumsulwa obungaphezu kuka-99%.

●Yiziphi Izinzuzo ZazoI-Thiamine Hydrochloride ?

I-Thiamine hydrochloride iguqulwa ibe uhlobo olusebenzayo lwe-thiamine pyrophosphate (TPP) emzimbeni womuntu, futhi idlala imisebenzi eminingi yomzimba:

1. Umongo wemetabolism yamandla:njenge-coenzyme ye-α-ketoacid decarboxylase, ibamba iqhaza ngokuqondile enqubweni yokuguqulwa kweglucose ibe yi-ATP. Uma ishoda, iholela ekuqongeleleni kwe-pyruvate, okubangela i-lactic acidosis kanye nenkinga yamandla.

2. Ukuvikelwa kwesistimu yezinzwa:Ukugcina ukuqhutshwa okuvamile kwama-nerve impulses. Ukuntuleka okukhulu kubangela i-beriberi, enezimpawu ezivamile ezihlanganisa i-peripheral neuritis, i-muscular atrophy, nokwehluleka kwenhliziyo. Ngokomlando, kubangele ubhubhane olukhulu e-Asia, kwashona amakhulu ezinkulungwane zabantu minyaka yonke.

3. Inani locwaningo olusafufusa:

Ukuvikelwa kwe-myocardial:Ukugxiliswa kwe-10μM kungaphikisa ukulimala kweseli ye-acetaldehyde-induced myocardial, kuvimbele ukusebenza kwe-caspase-3, futhi kunciphise ukwakheka kwe-protein carbonyl.

I-Anti-neurodegeneration:Ezivivinyweni zezilwane, ukuntula kungaholela ekuqongeleleni okungavamile kwephrotheni ye-β-amyloid ebuchosheni, ehlobene nesifo se-Alzheimer's.

Amaqembu asengozini enkulu yokuntula ahlanganisa:ukusetshenziswa isikhathi eside kwerayisi elimhlophe elicolisisiwe kanye nofulawa, izidakwa (i-ethanol ivimbela ukumuncwa kwe-thiamine), abesifazane abakhulelwe, kanye neziguli ezinesifo sohudo esingapheli.

●Yini Isicelo OfI-Thiamine Hydrochloride ?

1. Imboni yokudla (isabelo esikhulu kunazo zonke):

Izithuthukisi zomsoco:ingezwe emikhiqizweni yamacereal (3-5mg/kg), ukudla kwezingane (4-8mg/kg), kanye neziphuzo zobisi (1-2mg/kg) ukubuyisela ukulahleka kwemisoco okubangelwa ukucubungula kahle.

Izinselelo zobuchwepheshe:Ngenxa yokuthi kulula ukubola endaweni ene-alkaline, okuphuma kuyo okufana ne-thiamine nitrate kuvame ukusetshenziswa esikhundleni sokudla okubhakiwe.

2. Inkundla yezokwelapha:

Izinhlelo zokusebenza zokwelapha:imijovo isetshenziselwa ukwelashwa okuphuthumayo kwe-beriberi (i-neurological/heart failure), futhi amalungiselelo omlomo asetshenziswa njengezokwelapha ezisizayo ze-neuritis kanye ne-indigestion.

Ukwelapha okuhlanganisiwe:kuhlanganiswe nama-magnesium ejenti ukuthuthukisa ukusebenza kahle kwe-Wernicke encephalopathy kanye nokunciphisa izinga lokuphindaphinda.

3. Ezolimo kanye ne-biotechnology:

Izinto ezisiza ukumelana nezifo zezitshalo:Ukwelashwa kokugxilisa okungu-50mM kwerayisi, ukhukhamba, njll., kuvula izakhi zofuzo ezihlobene ne-pathogen (ufuzo lwe-PR), futhi kuthuthukisa ukumelana nesikhunta namagciwane.

Okuphakelayo okungeziwe:Thuthukisa ukusebenza kahle kwemetabolism kashukela emfuyweni nasezinkukhuni, ikakhulukazi ezindaweni ezicindezela ukushisa (ukwanda kwesidingo sokuphuma komjuluko).

● Ikhwalithi Ephezulu Yokunikezela Ngezinto EzintshaI-Thiamine HydrochlorideImpushana