●YiniI-Sclareol ?
I-Sclareol, igama lamakhemikhali (1R,2R,8aS)-decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol, ifomula yamangqamuzana C₂₀H₃₆O₂, isisindo samangqamuzana 308.350-108-308,308-CAS. Kuyinhlanganisela ye-bicyclic diterpenoid, ebukeka njengempushana ecwebezelayo emhlophe, indawo encibilikayo engu-95-105℃, indawo yokubilisa engu-398.3℃, engancibiliki emanzini, futhi encibilika kalula kuzinyibilikisi zemvelo. Isici sayo esiyinhloko ukuthi inephunga elihlala isikhathi eside elifana ne-ambergris, elinephunga elithambile kanye nokusakazwa okunamandla, okuyenza ibe impahla eluhlaza efanelekile yamakha asezingeni eliphezulu.
Umthombo wemvelo ngokuyinhloko i-inflorescence neziqu namaqabunga esitshalo seLamiaceae i-Salvia Sclarea L., esilinywa ngezinga elikhulu ezindaweni eziphakeme zezintaba njengasenyakatho yeShaanxi neHonghe, Yunnan, eChina. Ngenxa yomehluko omkhulu wokushisa phakathi kwemini nobusuku kanye nomswakama ofanelekile, i-clarysol kulezi zindawo ezikhiqizayo inobumsulwa obuphezulu kanye nephunga elimnandi.
Kunezindlela ezimbalwa eziyinhloko zokwenza i-sclareol:
1. Ukuhlanganiswa kwamakhemikhali
Ngokuvamile,i-sclareolI-extract isetshenziswa njengempahla eluhlaza yokukhipha nokuhlanza. Izinsalela ze-sclareol ngemva kokukhipha uwoyela zincibilika ku-ethanol, futhi i-sclareol idonswa ngendlela yezinaliti ezimhlophe ngemva kokubanda okunezinga lokushisa eliphansi, ukuhlunga, ukwelashwa kwekhabhoni ecushiwe, ukuhlanjululwa nezinye izinyathelo. Ngemuva kokuphelelwa amandla kwamanzi kwe-centrifugal, ukomiswa kwe-vacuum, ukuchotshozwa nokuhlolwa, i-sclareol enokuqukethwe okuphezulu kotshwala ingatholakala.
2. I-Biosynthesis
Ukwakhiwa kwefekthri ye-yeast cell ye-brewer's yeast: Ocwaningweni, ama-synthases amabili e-TPS kanye ne-LPPs ku-sage aqale ahlanganiswa ne-yeast gene, eyandisa ngempumelelo ukukhiqizwa kwei-sclareol. Khona-ke i-N-terminus ye-TPS-LPPS yaxhunywa engxenyeni yeprotheni ebopha i-maltose ukuze kuthuthukiswe ukuqina kwe-enzyme futhi kwandiswe isivuno futhi. Khona-ke, ithimba locwaningo lahlukanisa yonke indlela ye-metabolic yaba amamojula amathathu: indlela ye-metabolic emaphakathi yokuhlinzeka nge-acetyl coenzyme A, indlela ye-isoprenoid biosynthesis kanye nemojula yesici sokulawula sokuguqulwa kwesistimu. Ngokubuyisela endaweni kanye nokususwa kwezinye izakhi zofuzo ezihlobene, uhlobo lwe-chassis olungahlinzeka ngokuphumelelayo nge-acetyl-CoA ne-NADPH lwakhiwa, futhi ukukhiqizwa kwe-sclareol kwathuthukiswa nakakhulu ngokuveza izakhi zofuzo ngokweqile. Ekugcineni, umphumela wemojula ngayinye ekuhlanganiseni kwe-sclareol wahlaziywa ngephrofayili ye-metabolic ye-strain eyakhiwe, futhi kwatholakala ukuthi amamojula amathathu anomphumela we-synergistic. Ukuvutshelwa kwe-Fed-batch kwenziwa kuma-shake flasks nama-bioreactors, futhi ekugcineni i-sclareol yahlanganiswa kahle e-Saccharomyces cerevisiae kusetshenziswa i-glucose njengento eluhlaza, enesivuno esingu-11.4 g/L.
●ZiyiniIzinzuzoKwe I-Sclareol ?
Ucwaningo lwakamuva luveze umsebenzi webhayoloji onamacala amaningi we-sclareol, ikakhulukazi emkhakheni wezifo zesistimu yezinzwa:
1. I-Anti-inflammatory kanye ne-neuroprotective:
Ivimbela ukusebenza ngokweqile kwe-microglia, inciphisa amazinga ezici ezivuthayo i-TNF-α ne-IL-1β, ikhulula ukuphazamiseka kokunyakaza kumagundane ayimodeli ka-Parkinson, futhi ivikela i-dopamine neurons;
Thuthukisa ukusebenza kwengqondo kumamodeli esifo i-Alzheimer's. Umthamo we-50-200mg/(kg·d) ungavimbela ukusebenza kwama-astrocyte ebuchosheni futhi unciphise ukubekwa kwe-β-amyloid protein.
2. Umsebenzi wokulwa nomdlavuza:
Ine-cytotoxicity eqinile emigqeni yamaseli omdlavuza njengegundane leukemia (P-388) kanye ne-human epidermal carcinoma (KB), futhi ivimbela ukwanda kwesimila ngokudala i-apoptosis.
3. I-antibacterial kanye ne-antioxidant:
Ine-spectrum ebanzi yokuvimbela ukukhula kwamagciwane, futhi ukusebenza kahle kwayo kwe-antioxidant kuphindwe izikhathi ezingu-50 kunovithamini E, ofanele ukugqokwa kwamanxeba kanye nemikhiqizo yokunakekelwa kwesikhumba elwa nokuguga.
●ZiyiniIsiceloOf I-Sclareol ?
1. Imboni yephunga nephunga:
Njengoba iwumgogodla we-ambergris, ithatha indawo ye-ambergris engokwemvelo evela ku-sperm whale esengozini. Inani elincane lisetshenziswa ngokuqondile kumakha asezingeni eliphezulu ukunikeza iphunga umuzwa ongapheli futhi owendlalekile.
2. Ucwaningo nokuthuthukiswa kwemithi:
Izidakamizwa ze-Alzheimer's/Parkinson's disease: amaphilisi omlomo noma imijovo ingene ocwaningweni lwangaphambi komtholampilo, oluqondise ekuvinjweni kwe-neuroinflammation;
Ukwelashwa kwe-anti-cancer adjuvant: kuhlanganiswe nemithi yokwelapha ngamakhemikhali ukuze kuthuthukiswe ukubulawa kwamaseli esimila.
3. Izimonyo nokudla:
Imikhiqizo yokunakekelwa kwesikhumba elwa nokuguga: engeza u-0.5% -2% ukuze uvimbele ukuthwebula izithombe futhi unciphise i-ultraviolet erythema;
Izilondolozi zemvelo: ezisetshenziswa ekudleni okunamafutha ukwandisa isikhathi seshelufu, futhi ziphephile kunemikhiqizo yokwenziwa yamakhemikhali.
●NEWGREEN Supply High QualityI-SclareolImpushana
Isikhathi sokuthumela: Jul-18-2025
