●Yini?I-L-Citrulline?
I-L-Citrulline i-α-amino acid engeyona i-proteinogenic, eqanjwe ngososayensi abaqala ukuyihlukanisa ne-watermelon (Citrullus lanatus) ijusi ngo-1930. Igama layo lekhemikhali yi-(S) -2-amino-5-ureidopentanoic acid, enefomula yamangqamuzana ye-C₆H₁₃1 N₃9 yenombolo ye-CAS ye-5₃₃9 yesisindo 372-75-8237. Ukukhiqizwa kwezimboni zanamuhla ikakhulukazi kwenzeka ngezindlela ezimbili:
Isizinda semvelo: sihlukanisiwe nezitshalo ze-cucurbitaceae ezifana nekhabe nekhukhamba, kodwa ngokusebenza kahle okuphansi kanye nezindleko eziphezulu;
I-Biosynthesis: isizukulwane se-catalytic kumjikelezo we-urea sisebenzisa i-ornithine ne-carbamoyl phosphate njengama-substrates, noma ukuguqulwa kwe-oxidative ye-arginine ngaphansi kwesenzo se-nitric oxide synthase (NOS).
Izakhiwo zomzimba namakhemikhalikwe I-L-Citrulline :
Izakhiwo kanye ne-solubility: i-crystalline powder emhlophe, ukunambitheka okumuncu kancane; Incibilika kalula emanzini (i-solubility 200g/L, 20℃), cishe engancibiliki kuzincibilikisi zemvelo njenge-ethanol ne-ether;
Izakhiwo zokubuka: ukuzungezisa okuqondile +24.5°~+26.8° (c=8, 6N HCl), okuyinkomba eyinhloko yokuhlonza ubuqiniso;
Ukukhubazeka kokuzinza: ukuzwela ekukhanyeni nasekushiseni, indawo yokuncibilika ingu-214-222 ℃ (amafomu ahlukene ekristalu), ukubola kalula ngaphezu kuka-100 ℃; idinga ukuvalwa futhi igcinwe kude nokukhanya kanye nezinga lokushisa eliphansi (0-5 ℃);
Izindinganiso zokulawula ikhwalithi: imikhiqizo yebanga lemithi idinga izinsimbi ezisindayo ≤10ppm, okuqukethwe kwamanzi ≤0.30%, nezinsalela zokubasa ≤0.10% (i-AJI92 ejwayelekile).
●ZiyiniIzinzuzoKweI-L-Citrulline ?
Inani eliyinhloko le-L-citrulline lisemandleni ayo okuguqula ibe i-arginine futhi ikhulule i-nitric oxide (NO), ngaleyo ndlela isebenze imiphumela eminingi yomzimba:
Ukuvikelwa Kwenhliziyo
Khipha umfutho we-vascular futhi uthuthukise ukugeleza kwegazi nge-NO-mediated vascular smooth muscle relaxation;
Ucwaningo olwenziwa yi-Texas A&M University e-United States luqinisekisile ukuthi indlela yayo yomphumela we-vasodilatory ifana "ne-Viagra yemvelo", enezinga lokuthuthukiswa kwe-40% yokungasebenzi kahle kwe-erectile futhi ayikho imiphumela emibi yezidakamizwa.
I-Metabolism kanye Nokulawulwa Kwamasosha omzimba
Khuthaza umjikelezo we-urea wesibindi, usheshise i-ammonia metabolism, futhi unciphise ukuhlushwa kwe-ammonia egazini;
Khulisa umsebenzi we-macrophage futhi uthuthukise amandla e-antiviral (njengezinga lokususa igciwane lomkhuhlane likhuphuke ngo-35%).
Izinzwa Nezimotor Function
Yeqa umgoqo wegazi nobuchopho ukuze ukhuphule amazinga CHA ebuchosheni futhi uthuthukise ikhono lokubuyisa ulwazi lwenkumbulo;
I-Neutralize izinhlobo ze-oxygen esebenzayo (ROS) ezikhiqizwa ukuzivocavoca futhi wandise isikhathi sokukhuthazela kwemisipha ngama-22%.
●ZiyiniIsiceloOf I-L-Citrulline?
1. Imboni Yezempilo:
Imikhiqizo yokudla kwezemidlalo: ihlanganiswe nama-amino acid e-branched-chain, ukuhlushwa kwe-ketone yegazi ngemva kokuzivocavoca kugcinwa ngaphezu kwe-4mM, futhi isikhathi sokubuyisela imisipha sifinyezwa ngo-30% (isabelo semakethe yomhlaba wonke ngo-2024 singama-45%);
Isithuthukisi sokusebenza kwezocansi: i-citrulline ingakhuthaza i-vasodilation futhi ithuthukise ukungasebenzi kahle kwe-erectile
2. Imboni Yokudla:
I-preservative yemvelo: vimbela ukwanda kwama-microorganisms emikhiqizweni yenyama yasemanzini, futhi inani eliphelele le-colon ye-saumoni efrijini liyancipha ngo-90%;
Izithasiselo ezisebenzayo: "L-Citrulline + γ-aminobutyric acid" iyogathi esebenzayo, ilawula ngokuvumelanisa ukucindezela kwemithambo nokukhathazeka.
3. I-Biomedicine:
Ukwelashwa kwesifo i-Alzheimer's: vula indlela ye-cAMP/PI3K-Akt, uthuthukise ukuvezwa kwe-brain-derived neurotrophic factor (BDNF), futhi uthuthukise ikhono lokufunda nenkumbulo lamagundane ayimodeli ngo-40%;
Uhlelo lokulethwa kwezakhi zofuzo: njenge-pDNA nanocarrier, ukusebenza kahle kokudluliswa kwegciwane kuphakeme ngokuphindwe izikhathi eziyi-100 kune-liposomes, futhi kuzongena esivivinyweni somtholampilo seSigaba I sokwelashwa kwesimila sobuchopho ngo-2025.
4. I-Cosmetic Innovation
Kuhlanganiswe ne-polysaccharide moisturizers, ukuphumelela kokwelapha isikhumba esomile kungaphezu kuka-80%;
Ivimbela ukudluliswa kwezimpawu zemizwa ku-pruritic dermatitis futhi ilungise umsebenzi wokuvimbela i-stratum corneum.
●Ikhwalithi ephezulu ye-Newgreen SupplyI-L-CitrullineImpushana
Isikhathi sokuthumela: Jul-16-2025
