●KuyiniI-Hydrolyzed Collagen ?
I-Hydrolyzed collagen iwumkhiqizo obola i-collagen yemvelo ibe ama-peptide ama-molecule amancane (isisindo se-molecular 2000-5000 Da) ngokusebenzisa i-enzymatic hydrolysis noma ukwelashwa kwe-acid-base. Kulula ukumunca kune-collagen evamile. Izinsiza zayo eziyinhloko zihlanganisa:
Okusekelwe ezilwaneni: ikakhulukazi kukhishwe ku-tendon ye-Achilles yezinkomo (uhlobo I-collagen), isikhumba sengulube (uhlobo oluxubile I/III), isikhumba senhlanzi nezikali zezinhlanzi (hypoallergenic, uhlobo lwe-I lubalelwa ku-90%). Isikhumba senhlanzi sesiphenduke into eluhlaza eshisayo eminyakeni yamuva nje ngenxa yokuqukethwe kwaso okuphezulu kwe-collagen engama-80% futhi akukho mithetho yenkolo. Imithombo yendabuko yezilwane ezincelisayo isengozini yesifo senkomo, futhi izinga lokumuncwa kwe-collagen ye-molecule enkulu lingu-20% -30% kuphela. Ichithwa ibe ama-peptide ama-molecule amancane (2000-5000 Da) ngobuchwepheshe be-enzymatic hydrolysis, futhi i-bioavailability iyanda ibe ngaphezu kwama-80%.
Imithombo yezitshalo ezisafufusa: i-collagen eyenziwe yaba ngabantu evezwa imvubelo eyenziwe ngofuzo (njengohlobo lwe-III lwe-collagen ehlanganisayo yase-China Jinbo Bio).
●Izinqubo Ezivamile Zokulungiselela ZeI-Hydrolyzed Collagen:
1. Inqubo ye-Enzymatic hydrolysis
Ubuchwepheshe obuqondisiwe be-enzymatic cleavage: kusetshenziswa i-alkaline protease (njenge-subtilisin) kanye ne-flavour protease ye-synergistic hydrolysis, ukulawula ngokunembile isisindo samangqamuzana ebangeni lika-1000-3000 Da, futhi isivuno se-peptide sidlula ama-85%.
Izinyathelo ezintathu ezintsha: ukuthatha isikhumba se-tuna se-albacore njengesibonelo, ukwelashwa kokuqala kwe-alkali (ukususwa kwe-0.1 mol/L Ca(OH)₂), bese ukwelashwa ngokushisa ku-90℃ imizuzu engu-30, futhi ekugcineni i-gradient enzymatic hydrolysis, ukuze ingxenye ye-peptide enesisindo se-molecular engaphansi kuka-3kD iphendule u-85%.
2. I-Biosynthesis
Indlela ye-Microbial fermentation: kusetshenziswa izinhlobo ezakhiwe (ezifana ne-Pichia pastoris) ukuveza izakhi zofuzo ze-collagen ukuze kulungiswe i-collagen e-hydrolyzed, ubumsulwa bungafinyelela ngaphezu kwama-99%.
I-Nanoscale hydrolysis: ukulungiselela i-500 Da ultramicropeptides usebenzisa ubuchwepheshe obuxhunywe nge-ultrasound-enzyme, izinga lokumuncwa kwe-transdermal lenyuka ngo-50%.
●Ziyini Izinzuzo ZeI-Hydrolyzed Collagen?
1. “Izinga Legolide” Lesikhumba Esilwa Nokuguga
Idatha yomtholampilo: Ukuphathwa ngomlomo kwe-10g nsuku zonke izinyanga ezingu-6 kwandise ukunwebeka kwesikhumba ngo-28% futhi kunciphisa ukulahlekelwa kwamanzi e-transepidermal ngo-19%;
Ukulungiswa kwesithombe: Ukuvinjelwa kwe-matrix metalloproteinase MMP-1, ukujula kombimbi okwenziwa yi-UV kwehliswe ngo-40%.
2. Ukungenelela Kwezifo Ezihlangene Nezomzimba
I-osteoarthritis: Uhlobo lwe-II lwe-collagen peptide (kusuka ku-chicken sternal cartilage) lwehlise izinhlungu ze-WOMAC zeziguli ngama-35%;
I-Osteoporosis: Abesifazane be-Postmenopausal bengezwe ngo-5g weI-Hydrolyzed Collagennsuku zonke unyaka ongu-1, ukuminyana kwamathambo kukhuphuke ngo-5.6%;
Ukuphatha isisindo: Ukusutha okuthuthukisiwe ngokuvula i-GLP-1, ukuzungeza okhalweni kwehliswe ngesilinganiso esingu-3.2cm ezivivinyweni zamaviki angu-12.
3. Isimo Esiphuthumayo Sezokwelapha Nokuvuselelwa Kabusha
I-Plasma substitutes: Ukufakwa kwe-dose enkulu (> 10,000ml) ye-gelatin-based hydrolyzed collagen amalungiselelo akuthinti umsebenzi we-coagulation futhi isetshenziselwa ukwelashwa kwezinhlekelele;
Ukulungiswa kwamanxeba: Ukwengeza ama-collagen peptide ekushiseni izingubo kunciphisa isikhathi sokuphola ngo-30%.
●Ziyini IsicelosKwe I-Hydrolyzed Collagen ?
1. Ubuhle Nokunakekelwa Komuntu Siqu (Ukubalwa Kwama-60%)
Izihlungi ezijovwayo: I-collagen yohlobo lwe-III ehlanganisiwe (njenge-Shuangmei ne-Jinbo Bio) ithole ilayisense yedivayisi yezokwelapha yase-China ye-Class III, enezinga lokukhula lonyaka elingu-50%;
Ukunakekelwa kwesikhumba okusebenzayo:
Ama-Peptide anesisindo samangqamuzana angaphansi kwe-1000 Da asetshenziswa ku-essence (SkinCeuticals CE Essence) ukukhuthaza ukungena nokumuncwa;
Amamaski nama-lotions ahlanganiswe nezinto zokuthambisa, futhi izinga lokukhiya amanzi lamahora angu-48 lenyuka ngo-90%.
2. Ukudla Okusebenzayo Nemithi
Imakethe yomlomo: I-Collagen gummies kanye ne-hydrolyzed collagen oral liquids inokuthengiswa komhlaba wonke kwezigidigidi ezingama-4.5 zamaRandi (2023);
Izinto zokwelapha: ama-stents okulungisa amathambo namalunga, ama-cornea okwenziwa, kanye nezicelo zemithi evuselelayo emhlabeni wonke kwenyuke ngo-22% ngonyaka.
3. EzoLimo Nezemvelo
Ukudla kwezilwane ezifuywayo: Izinkampani eziningi zokudla kwezempilo yezilwane zengeza i-collagen e-hydrolyzed ekudleni kwesilwane.
Izinto ezisimeme: Iphrojekthi ye-EU Bio4MAT ithuthukisa amafilimu okupakisha abolayo ukuze kuncishiswe ukungcoliswa kwemfucuza yokudoba.
●NEWGREEN SupplyI-Hydrolyzed CollagenImpushana
Isikhathi sokuthumela: Jun-19-2025
