I-Glutathione: I-Antioxidant Enamandla

●YiniI-Glutathione ?

I-Glutathione (GSH) iyinhlanganisela ye-tripeptide (ifomula yamangqamuzana C₁₀H₁₇N₃O₆S) eyakhiwe yi-glutamic acid, i-cysteine.kanye ne-glycine exhunywe nguγ- amabhondi e-amide. Umnyombo wayo osebenzayo yiqembu le-sulfhydryl (-SH) ku-cysteine, elinikeza amandla anamandla okunciphisa.

Izinhlobo ezimbili ezinkulu ze-physiological ze-glutathione:

1. I-glutathione encishisiwe (GSH): ilandisa ngaphezu kwe-90% yenani eliphelele emzimbeni futhi iyindlela eyinhloko yemisebenzi ye-antioxidant kanye ne-detoxification; isusa ngokuqondile ama-radicals mahhala futhi ivikele amaseli emonakalweni we-oxidative.

2. I-glutathione ene-oxidized (GSSG): eyakhiwe yi-oxidation yama-molecule amabili e-GSH (GSSG), anomsebenzi obuthakathaka wokuphila; ngaphansi kwe-catalysis ye-glutathione reductase, kuncike ku-NADPH ukuthi yehliselwe ku-GSH ukuze kugcinwe ibhalansi ye-redox yeselula.

●Yiziphi Izinzuzo ZeI-Glutathione ?

1. Imisebenzi Eyisisekelo Yokuphila

Ukukhipha ubuthi nokuvikela isibindi:

I-Glutathione ingakwazi chelate izinsimbi ezisindayo (umthofu, i-mercury), ubuthi bezidakamizwa (njenge-cisplatin) nama-metabolites otshwala. Umjovo we-intravenous we-1800mg / ngosuku ungathuthukisa kakhulu ukusebenza kwesibindi, futhi izinga eliphumelelayo lokwelapha isifo sesibindi esidakayo lingaphezu kwama-85%.

I-Axiliary anti-tumor:

I-Glutathione ingakwazi rkhuphula i-chemotherapy nephrotoxicity, andise umsebenzi wamangqamuzana abulalayo emvelo (NK cells) izikhathi ezi-2, futhi avimbele ukucindezeleka kwe-tumor cell oxidative.

Ukuvikelwa kwe-Neurological and ophthalmic:

I-Glutathione kungaba rqeda izimpawu zokuqala zesifo sikaParkinson futhi unciphise i-dopamine neurotoxicity; ukusetshenziswa kwendawo kwamaconsi iso kungalungisa izilonda ze-cornea futhi kuvimbele ukuthuthukiswa kwe-cataract.

2. Izicelo Zezempilo Nobuhle

Ukulawulwa kokuzivikela komzimba okulwa nokuguga: Yenza kusebenze amaprotheni e-Sirtuins futhi ulibazise ukufinyezwa kwe-telomere; ukuthuthukisa umsebenzi we-lymphocyte futhi unciphise ukukhululwa kwezinto ezivuthayo;

Ukuba mhlophe nokususwa kwamabala: Vimba umsebenzi we-tyrosinase futhi unciphise ukukhiqizwa kwe-melanin. Kufakazelwe ngokomtholampilo ukuthuthukisa ukunwebeka kwesikhumba nokunciphisa ukujula kombimbi ngo-40%.

●Ziyini IsicelosKwe I-Glutathione ?

1. Inkundla yezokwelapha

Umjovo: usetshenziselwa ukuvikelwa kwe-chemotherapy (umthamo ongu-1.5g/m²), usizo lokuqala olunoshevu oyingozi, futhi udinga ukugcinwa kude nokukhanya;

Amalungiselelo omlomo: ukusetshenziswa kwesikhathi eside (200-500mg / isikhathi, ngaphezu kwezinyanga ezingu-6) ukwandisa izinqolobane ze-GSH zomzimba futhi kusize ekwelapheni isifo sesibindi esingapheli.

2. Ukudla Okusebenzayo

Izithako ze-Antioxidant: i-vitamin C ehlanganisiwe (i-500mg i-vitamin C ngosuku ingakhuphula amazinga e-GSH ngo-47%) noma i-selenium ukuthuthukisa ukungatheleleki;

Ukudla kokuvikela isibindi nesibindi: kwengezwegi-lutathioneiziphuzo ezisebenzayo ukusheshisa i-alcohol metabolism nokunciphisa ukulimala kwesibindi.

3. I-Cosmetic Innovation

I-Whitening essence: isetshenziswa kabanzi emakethe yase-Asia ukuvimbela i-melanin, kuhlanganiswe nobuchwepheshe be-microneedle ukuthuthukisa ukungena kwesikhumba;

Ifomula yokulwa nokuguga: i-liposome encapsulated GSH imelana nokulimala kwe-ultraviolet futhi yehlisa i-erythema yokuthwebula ngo-31% -46%.

4. Ukusetshenziswa Kwe-Emerging Technologies

Ukulethwa kwezidakamizwa okuhlosiwe: Ama-nanogel asabela nge-GSH angakwazi ukukhulula ngokulawulekayo izidakamizwa ze-chemotherapy (njenge-doxorubicin) endaweni yesimila, ukuthuthukisa ukusebenza kahle nokunciphisa imiphumela emibi;

Ukuvikelwa kwemvelo kanye nezolimo: Thuthukisa izinto ezingaboli futhi uhlole izithasiselo zokudla ukuze kuthuthukiswe ukuzivikela kwemfuyo nezinkukhu.

Kusukela kulungelo lobunikazi lokukhipha imvubelo kuya ekukhiqizweni ngobuningi kwezinkulungwane zamathani kubhayoloji yokwenziwa namuhla, inqubo ye-industrialization ye-glutathione iqinisekise ukuguqulwa "kokuqapha kwamaseli" kuya "kwinjini yobuchwepheshe". Esikhathini esizayo, ngokuphothulwa kokuqinisekiswa komtholampilo kwezinkomba ezintsha ze-neuroprotection kanye nokulwa nokuguga, le molecule ephethe impilo ye-antioxidant izoqhubeka nokuhlinzeka ngomfutho wesayensi empilweni yomuntu nokuphila isikhathi eside. 

●NEWGREEN SupplyI-Glutathione Impushana