●Yini? I-Chondroitin sulfate sodium?
I-Chondroitin Sulfate Sodium (CSS) iyi-asidi yemvelo ye-mucopolysaccharide enefomula yamakhemikhali ye-C₄₂H₅₇N₃Na₆O₄₃S₃X₂ (isisindo samangqamuzana esingaba ngu-1526.03). Ikhishwa kakhulu ezicutshini ze-cartilage zezilwane ezinjengezingulube, izinkomo, noshaka. Isakhiwo sayo samangqamuzana sakhiwe ngokushintshana kwe-D-glucuronic acid ne-N-acetylgalactosamine, equkethe amayunithi angama-50-70 e-disaccharide futhi ephethe amanani alinganayo e-acetyl namaqembu e-sulfate. Izinto ezisetshenziswayo eziphezulu zisathembele ku-cartilage entsha esezingeni eliphansi lokushisa, phakathi kwayo amathambo e-laryngeal yengulube kanye namathambo aphakathi kwekhala okuyisinqumo sokuqala sokukhishwa kwesigaba sezokwelapha ngenxa yokuqukethwe okuphezulu kwe-chondroitin sulfate A / C (okubalwa ngaphezu kwe-24% yesisindo esomile).
Inqubo yokukhiphaof I-Chondroitin sulfate sodium:
Ukukhishwa kwendabuko kudinga izinqubo ezine ezinembayo:
I-alkaline deproteinization: Cwilisa uqwanga kusisombululo esingu-2% se-sodium hydroxide bese ukhipha ngokushukumisa ekamelweni lokushisa.
Ukuhlanzwa kwe-Enzymatic: I-Hydrolyze ngama-enzyme e-pancreatic ku-53-54 ℃ amahora angu-7, futhi i-adsorb ukungcola ngekhabhoni ecushiwe;
Imvula ye-Ethanol: Lungisa i-pH ibe ngu-6.0 bese wengeza i-ethanol engu-75% ukuze imvula;
Ukuphelelwa amanzi emzimbeni nokomisa: Geza nge-ethanol engadonsi amanzi bese womisa ku-vacuum ku-60-65℃.
Ukuthuthukiswa kwenqubo: Izinkampani eziningi zethule izinto ezintsha zokusetshenziswa zebanga lemishini yezokwelapha, zisebenzisa uqwanga loshaka ukuze lukhishwe, ukuqinisekiswa kokungacutshungulwa kwegciwane kanye nenqubo ye-aseptic, kanye nokuhlolwa kwe-pyrogen ne-cytotoxicity ukuze kuhlangatshezwane namazinga omhlaba.
●ZiyiniIzinzuzoKwe I-Chondroitin sulfate sodium ?
1. Umnyombo Wokwelashwa Kwezifo Ezihlangene
Ukulungiswa kwe-cartilage: kuvuselela ama-chondrocyte ukuze ahlanganise i-collagen, athuthukise i-synovial fluid viscoelasticity, futhi anciphise ukungqubuzana okuhlangene ezigulini ze-osteoarthritis ngo-40%;
I-analgesia elwa nokuvuvukala: vimbela i-phospholipase A2 kanye ne-matrix metalloproteinase, yehlisa ukukhiqizwa kwabalamuli abavuvukalayo njenge-prostaglandin, futhi izinga lokunciphisa ubuhlungu lifinyelela ku-90% ngemva kwamasonto angu-12 okwelashwa.
2. Ukulawulwa Kwesistimu Yenhliziyo
Ukwehliswa kwe-lipid kanye nokuvikela imithambo yegazi: susa amadiphozithi e-lipid odongeni lwemithambo, wehlise kakhulu i-cholesterol ye-plasma, futhi wehlise indawo yama-atherosclerotic plaque ngo-60%;
I-Anticoagulation: Umsebenzi we-anticoagulant weI-Chondroitin sulfate sodium yi-0.45 izikhathi/mg ye-heparin, futhi i-thrombosis ivinjelwa ngohlelo lwe-fibrinogen.
3. Ukungenelela Kwezifo Ezihlukahlukene
Ukuvikelwa kokuzwa: lungisa amangqamuzana ezinwele ze-cochlear, futhi izinga elisebenzayo lokuvimbela ukungezwa okubangelwa i-streptomycin lidlula ama-85%;
Ukusetshenziswa kwe-Ophthalmic: thuthukisa i-metabolism yamanzi e-cornea, futhi kwandiswe ukukhishwa kwezinyembezi kweziguli ezineso elomile ngo-50%;
Amandla e-anti-tumor: i-chondroitin sulfate etholakala kushaka ivimbela ukwakheka kwamangqamuzana omdlavuza ngokuvimbela i-angiogenesis yesimila.
●ZiyiniIsiceloOf I-Chondroitin sulfate sodium?
1. Imakethe Ebusayo Ensimini Yezemithi
Ukunakekelwa kwezempilo okuhlanganyelwe: Amalungiselelo ahlanganiswe ne-akhawunti ye-glucosamine engama-45% emakethe yezidakamizwa zomhlaba wonke ye-osteoarthritis
Izidakamizwa zenhliziyo: Ukuphathwa ngomlomo nsuku zonke kwe-0.6-1.2g kunganciphisa izinga lokufa kwesifo senhliziyo ngama-30%.
2. Amadivayisi Ezokwelapha Kanye Nokusungulwa Kwezinto Ezintsha Zezokwelapha
I-Ophthalmic viscoelastics: Ukuhlanzeka okuphezuluchondroitin sulfate sodiumisetshenziselwa ukuhlinzwa kwe-cataract ukuvikela izinga lokusinda lamaseli e-corneal endothelial angaphezu kwama-95%;
Izigcwalisi zobuhle bezokwelapha: zingasetshenziswa njengezinto zokusetshenziswa ezingavuthiwe zebanga lomjovo lomjovo wokukhanya kwamanzi nokugcwaliswa kwesikhumba, futhi zikhuthaze ukusebenza kahle kokuvuselelwa kwe-collagen ngama-70%;
Ukuphulukiswa kwesilonda: Ijeli engu-0.2% isheshisa ukuphulukiswa kwezilonda ezinyaweni zesifo sikashukela, futhi izinga lokuncipha kwesilonda ezinsukwini ezingu-21 lifinyelela ku-80%.
3. Ukunwetshwa Kwemikhiqizo Esebenzayo Yabathengi
Ukunakekelwa kwesikhumba kanye nokulwa nokuguga: Ukusifaka kumakhilimu kungakhuphula umswakama wesikhumba ngo-16% futhi kunciphise ukujula kwemibimbi ngo-29%;
Ukudla kwezempilo: Inkampani yethule "CSS+fish oil" uswidi othambile osebenzayo ukuze ulawule ngasikhathi sinye ukuguquguquka okuhlangene kanye namazinga e-lipid yegazi.
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●Ikhwalithi ephezulu ye-Newgreen Supply I-Chondroitin sulfate sodium Impushana
Isikhathi sokuthumela: Aug-12-2025
