I-Chenodeoxycholic Acid: I-Core Raw Material Yokwelashwa Kwezifo Zesibindi, Ukudla Okusebenzayo kanye Nezinto Eziphilayo

● YiniI-Chenodeoxycholic Acid ?

I-Chenodeoxycholic Acid (CDCA) ingenye yezingxenye eziyinhloko ze-vertebrate Bile, ibalwa ku-30% -40% we-bile acid yomuntu, futhi okuqukethwe kwayo kuphezulu kakhulu ku-bile yamahansi, amadada, izingulube nezinye izilwane.

Ukuthuthukiswa kobuchwepheshe besimanje bokukhipha:

Ukukhishwa kwe-CO₂ Supercritical: ukukhishwa ngaphansi kwezimo eziphansi zokushisa nezimo ezicindezelayo ukuze kugwenywe izinsalela ze-organic solvent, futhi ubumsulwa bungafinyelela ngaphezu kwe-98%;

Indlela ye-Microbial fermentation: kusetshenziswa izinhlobo ezakhiwe ngofuzo (ezifana ne-Escherichia coli) ukuze kuhlanganiswe i-CDCA, izindleko zincishiswa ngo-40%, okuhambisana nokuthambekela kokukhiqizwa kwemithi eluhlaza;

Indlela ye-Chemical synthesis: usebenzisa i-cholesterol njengesandulela, itholakala ngokusabela okunezinyathelo eziningi, ezifanele imikhiqizo yezinga eliphezulu lemithi.

Izakhiwo zomzimba kanye namakhemikhali weI-Chenodeoxycholic Acid :
Igama lekhemikhali: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Ifomula yemolekyuli: C₂₄H₄₀O₄
Isisindo sengqamuzana: 392.58 g/mol
Ukubukeka: i-crystalline powder emhlophe
Ukunyibilika: kuncibilika kancane emanzini, kuncibilika kalula ku-ethanol, ether, chloroform
Indawo encibilikayo: 165-168 ℃
Ukuzinza: kuzwela ekukhanyeni nasekushiseni, kudinga ukufakwa efrijini kude nokukhanya (2-8℃)

● Yiziphi izinzuzo ze-I-Chenodeoxycholic Acid ?

1. Ukuqedwa Kwe-Cholesterol Gallstones

Inqubo: vimbela i-HMG-CoA reductase yesibindi, yehlise ukwakheka kwe-cholesterol, ikhuthaze ukukhishwa kwe-bile acid, futhi kancane kancane ichithe amatshe enyongo we-cholesterol;

Idatha yomtholampilo: 750mg CDCA ngosuku izinyanga eziyi-12-24, izinga lokuqedwa kwe-gallstone lingafinyelela ku-40% -70%.

2. Ukwelashwa Kwe-Primary Biliary Cholangitis (Pbc)

Izidakamizwa zomugqa wokuqala: I-FDA igunyaze i-Chenodeoxycholic Acid CDCA ye-PBC, ithuthukisa izinkomba zokusebenza kwesibindi (ALT/AST yehliswe ngaphezu kwe-50%);

Ukwelapha okuhlangene: kuhlangeneI-Chenodeoxycholic Acidnge-ursodeoxycholic acid (UDCA), ukusebenza kahle kuthuthukiswa ngama-30%.

3. Ukulawulwa Kwezifo Ze-Metabolic

Ukwehlisa i-lipids yegazi: ukwehlisa i-serum total cholesterol (TC) kanye ne-low-density lipoprotein (LDL);

I-Anti-diabetes: ukuthuthukisa ukuzwela kwe-insulin, ukuhlolwa kwezilwane kukhombisa ukuthi ushukela wehla ngo-20%

4. I-Anti-Inflammatory And Immune Regulation

Vimbela indlela ye-NF-κB futhi unciphise ukukhululwa kwezinto ezivuthayo (TNF-α, IL-6);

Ukuhlolwa kwemitholampilo kubonise ukuthi izinga lokuthuthukiswa kwe-fibrosis yesibindi ezigulini ezine-non-alcoholic fatty liver disease (NAFLD) lidlula i-60%.

● Yiziphi Izicelo ZeI-Chenodeoxycholic Acid ?

1. Inkundla yezokwelapha

Ukwelashwa kwe-Gallstone: amaphilisi e-CDCA (250mg / tablet), umthamo wansuku zonke we-10-15mg / kg;

Ukwelashwa kwe-PBC: amalungiselelo ayinhlanganisela nge-UDCA (njenge-Ursofalk®), ukuthengiswa konyaka emhlabeni wonke kudlula i-US$500 million;

Ucwaningo lwe-anti-tumor: ukuvimbela ukwanda kwamangqamuzana omdlavuza wesibindi ngokulawula ama-receptors e-FXR, ukungena ezivivinyweni zomtholampilo zeSigaba II.

2. Ukudla Okusebenzayo Nemikhiqizo Yezempilo

amaphilisi okuvikela isibindi: i-compound formula (CDCA + silymarin), ukunciphisa ukulimala kwesibindi esidakayo;

Ama-capsules ehlisa i-Lipid: ahambisanayo nemvubelo ebomvu ekhishwe irayisi ukulawula i-lipid metabolism yegazi.

3. Ukufuywa Kwezilwane Nokufuywa Kwezilwane Zasemanzini

Izithasiselo zokudla: thuthukisa imfuyo kanye ne-fat fat metabolism, yehlise izinga lamafutha esiswini;

Impilo yezinhlanzi: ingeza u-0.1%i-chenodeoxycholic acidukuthuthukisa ukumelana nesifo se-carp nokwandisa izinga lokusinda ngo-15%.

4. Izimonyo Nokunakekela Siqu

I-Essence Anti-inflammatory: 0.5% -1% ukwengeza, ukuthuthukisa ukuzwela kwesikhumba nokuzwela kwesikhumba;

Ukunakekelwa kwesikhumba: vimbela i-Malassezia futhi unciphise ukukhiqizwa kwe-dandruff.

Kusukela ekukhishweni kwe-bile yendabuko kuya ekuhlanganiseni kwe-microbial, i-chenodeoxycholic acid ishintsha kusukela "esithako semvelo" kuya "emuthini onembile". Ngokujula kocwaningo ngezifo ze-metabolic kanye ne-anti-tumor, i-CDCA ingaba yisisekelo sempahla yokwelashwa kwezifo zesibindi, ukudla okusebenzayo kanye nama-biomaterials, okuholela igagasi elisha lemboni yezempilo eyizigidi eziyizinkulungwane eziyi-100.

● Ukunikezela nge-NEWGREENI-Chenodeoxycholic AcidImpushana