●Yini I-bilirubin?
I-Bilirubin ingumkhiqizo wokubola kwamaseli abomvu egazi aguga. Cishe amangqamuzana abomvu egazi angaba yizigidi ezi-2 ahlakazeka obendeni nsuku zonke. I-hemoglobin ekhululiwe iguqulwa nge-enzymatic ibe i-bilirubin engaqondile encibilika kumafutha, bese iguqulwa ibe yi-bilirubin eqondile encibilika emanzini ngesibindi futhi ekugcineni ikhishelwe emathunjini ngenyongo. Noma yikuphi ukungahambi kahle kulolu chungechunge lwe-metabolic (okufana ne-hemolysis, ukulimala kwesibindi noma ukuvinjelwa kwe-bile duct) kungaholela ekuqongeleleni kwe-bilirubin futhi kubangele i-jaundice.
Ucwaningo lwakamuva luthole ukuthi lapho ukuhlushwa kwe-bilirubin kuyinto≥17.05μi-mol/L, ukuhlobana phakathi kwesifo sikashukela nesifo sohlangothi kungavinjelwa, futhi ingozi yokushaywa unhlangothi ezigulini ezinesifo sikashukela sabesilisa iyancipha izikhathi ezingu-2.67. Umshini ukuvimbela amaprotheni azwela kakhulu e-C kanye ne-systemic immune immune index, ukubeka amabhuleki "esiphepho esivuthayo".
I-Bilirubin ikhishwa esibindini sengulube nesoshaka, i-gallbladder yezinkomo kanye ne-brainstem. Sizuze impumelelo ngokusungula izinto zobuchwepheshe:
Ukukhishwa kwe-CO₂ Supercritical: gcina izithako ezisebenzayo ngaphansi kwemvelo yokushisa ephansi, gwema izinsalela ze-solvent, futhi ukhulise ubumsulwa bube ngaphezu kwama-98%;
Inqubo ye-biological enzymatic hydrolysis: ukuguqulwa okuqondile kwe-bilirubin glycosides ibe ama-aglycone asebenzayo, okwandisa i-bioavailability ngo-50%.
●Yiziphi izinzuzo ze-I-bilirubin ?
1. Ukuvikelwa kwe-Antioxidant
I-Bilirubin iyi-antioxidant ebalulekile engapheli emzimbeni, engakwazi ukuqeda ngempumelelo ama-radicals mahhala (njenge-superoxide ne-hydrogen peroxide) futhi inciphise umonakalo wokucindezelwa kwe-oxidative kulwelwesi lwamaseli, amaprotheni kanye ne-DNA. Ucwaningo lubonise ukuthi ukugxila okuphansi kwe-bilirubin kungathuthukisa ukuzivikela kweseli emonakalweni we-oxidative ngokwenza kusebenze izindlela zokusayina ze-antioxidant (njengendlela ye-Nrf2), futhi ingase yehlise ngisho nengozi ye-atherosclerosis kanye nezifo ze-neurodegenerative.
2. Umsebenzi we-Immunomodulatory
I-bilirubiningalawula izimpendulo zamasosha omzimba ngokuvimbela ukukhululwa kwezinto ezivuthayo (njenge-TNF-α ne-IL-6). Kunganciphisa ukulimala kwezicubu ezibangelwa ukuvuvukala ngokweqile ngenkathi kugcinwa ibhalansi yamasosha omzimba. Isibonelo, i-bilirubin ephakeme kancane ku-jaundice yemvelo yezingane ezisanda kuzalwa ingasiza ekunciphiseni ingozi yokutheleleka ngale ndlela. Kodwa-ke, ukugxila ngokweqile kungavimbela ukusebenza kwamangqamuzana omzimba futhi kwandise amathuba okutheleleka.
3. Iseli kanye neuroprotection
I-Bilirubin inomphumela okhethekile wokuvikela ohlelweni lwezinzwa. Ingawela umgoqo wegazi nobuchopho futhi ivikele ama-neurons ku-ischemia noma izilonda eziwohlokayo ngokuvimbela i-glutamate excitotoxicity kanye nokunciphisa ukulimala kwe-oxidative. Ngaphezu kwalokho, i-bilirubin inganciphisa nokulimala kwamangqamuzana esibindi, amangqamuzana e-myocardial, njll ngaphansi kwe-hypoxia noma ukuchayeka kwe-toxin, futhi igcine ukusebenza kwesitho.
4. Thuthukisa umzimba kanye nomjikelezo wokuphuma
Inqubo ye-metabolici-bilirubiniyisixhumanisi esibalulekile ekugayweni kabusha kwe-hemoglobin emzimbeni. Ngemuva kokubola kwe-hemoglobin emangqamuzaneni abomvu egazi aguga abe yi-bilirubin, idinga ukuhlanganiswa nesibindi bese ikhishelwa emathunjini nge-bile. Amagciwane asemathunjini ayiguqula abe yi-urobilinogen, ingxenye yayo iphinde ifakwe (i-enterohepatic circulation), kanti enye ikhishwa ngendle. Lo mjikelezo awusizi nje kuphela ukususa udoti we-metabolic, kodwa futhi uxhumana nezitshalo zamathumbu ukuze kuthinte ibhalansi ye-metabolic jikelele.
5. Ukulimala kwamazinga angavamile
I-bilirubin eyeqile: Ingase ibangele i-jaundice (isikhumba sibe phuzi kanye ne-sclera), evame kakhulu esibindini sokusha kwesibindi, ukuvinjelwa kwesibindi noma izifo ze-hemolytic. Uma i-bilirubin yamahhala iphezulu kakhulu, ingadlula kumgoqo wegazi nobuchopho futhi ibangele i-kernicterus yengane esanda kuzalwa (ukulimala kobuchopho).
I-bilirubin ephansi kakhulu: Ucwaningo lwakamuva luthole ukuthi ukunyuka okuncane kwe-bilirubin kungase kube nomphumela wokuvikela, kuyilapho amazinga aphansi kakhulu angase ahlotshaniswe nengozi eyengeziwe yesifo senhliziyo nemithambo yegazi kanye nesifo sokuzivikela komzimba, kodwa indlela ethile isadinga ukucwaninga.
●Kuyini Ukunwetshwa Kwesicelo Sezokwelapha I-bilirubin ?
1. Izinto ezisetshenziswayo zokwenziwa kwemithi
I-Bilirubin iyingxenye eyinhloko ye-bezoar yokwenziwa futhi isetshenziswa emithini engaphezu kwe-130, njengezidakamizwa zenhliziyo nemithambo yegazi (i-85% esebenza ngempumelelo ekudambiseni isifo senhliziyo) kanye namalungiselelo okulawula ukunqamuka kokuya esikhathini.
2. Amalungiselelo e-Nano (BRNPs)
Ngobuchwepheshe be-nanocarrier, ukusebenza kahle nokuqondiswa kwe-bilirubin kuye kwathuthukiswa kakhulu:
I-acute gastric ulcer: i-chitosan-bilirubin (CS-BR), ivimbela ukukhiqizwa kwezinto ezivuthayo futhi ikhuthaze ukuvuselelwa kwe-mucosal
Isibindi esinamafutha angewona uphuzo oludakayo: i-polyethylene glycol-bilirubin (PEG-BR), yehlisa ukunqwabelana kwamafutha esibindi ngo-30%, futhi yehlisa ama-triglycerides ngama-40%
I-Psoriasis: i-hydrogeli-bilirubin, ithuthukisa izilonda zesikhumba, ngaphandle kobuthi besistimu ye-corticosteroids
I-Stroke: I-TRPM2 channel inhibitor A23, ivimba i-bilirubin neurotoxicity futhi inciphisa usayizi we-infarct.
Okunye ukusetshenziswa kwe-bilirubin: ukufuywa kwezilwane, ukuvikelwa kwemvelo kanye nemikhiqizo esebenzayo
I-Aquaculture: Ukwengeza ama-bilirubin angu-4% ukuze ukondle kuphinda kabili ukukhiqizwa kwezimfanzi ezimhlophe futhi kwandisa inzuzo yesisindo se-carp ngo-155.1%;
Ukudla okusebenzayo: I-anti-glycation oral liquid, ehlanganiswe ne-antioxidant ye-bilirubin ukubambezela ukuguga kwesikhumba.
●NEWGREEN Supply I-bilirubinImpushana
Isikhathi sokuthumela: Jun-09-2025
