• YiniI-Bifidobacterium Longum ?
I-Bifidobacterium longum ibilokhu ibambe isikhundla esimaphakathi ekuhloleni kwesintu ubudlelwano phakathi kwamagciwane nempilo. Njengelungu elivame kakhulu futhi elisetshenziswa kabanzi lohlobo lwe-Bifidobacterium, usayizi wemakethe yomhlaba wonke kulindeleke ukuthi udlule ama-US $ 4.8 billion ngo-2025, ngesilinganiso sokukhula sonyaka esiyi-11.3%. Ucwaningo lwango-2025 olwanyatheliswa ku-Nature Microbiology lwaqinisekisa ukuthi i-Bifidobacterium longum ingakwazi ukulawula ukuziphatha kokukhathazeka nge-axis yobuchopho, okukhomba ukuthi lo "mdabu wamathumbu" ulungisa kabusha isimo semboni yezempilo endaweni entsha.
I-Bifidobacterium longum: I-Gram-positive, non-spore-forming, futhi iqinile i-anaerobic, ikhula kahle kakhulu ku-36-38°C futhi ibekezelela ububanzi be-pH obungu-5.5-7.5. Ukuminyana kwamaseli asebenzayo ku-MRS Culture medium kungafinyelela ku-10^10 CFU/mL.
Ukulungiswa kwezimboni: Ngokusebenzisa ubuchwepheshe be-microencapsulation, izinga lokusinda kwamaseli likhuphukela kuma-92%.
• Yiziphi Izinzuzo ZazoI-Bifidobacterium Longum?
Ngokusekelwe ezifundweni zomhlaba ezingaphezu kuka-3,000, i-Bifidobacterium longum ikhombisa imiphumela ehlukahlukene yezinto eziphilayo:
1. Ukuphathwa Kwempilo Yamathumbu
I-Microbiome Modulation: Icindezela amagciwane ngokukhipha ama-peptide e-antimicrobial (njenge-bifidocin), ikhulise ukuchichima kwe-bifidobacteria yamathumbu izikhathi ezi-3-5.
Ukulungiswa kwe-Mucosal: Ilawula ukubonakaliswa kwamaprotheni e-occludin, inciphisa ukuvuthwa kwamathumbu (i-FITC-dextran permeability yehle ngo-41%), futhi yehlisa i-leaky gut syndrome.
2. Ukulawulwa Kwamasosha omzimba
Ibhalansi ye-Cytokine:I-Bifidobacterium longumivuselela i-IL-10 secretion (yandisa ukuhlushwa ngezikhathi ze-2.1), ivimbela i-TNF-α (iyancipha ngo-58%), futhi ithuthukise isifo sofuba esivuthayo.
Ukungenelela Kokungezwani Nomzimba: Kwehlisa amazinga e-serum IgE ngo-37% futhi kunciphisa izehlakalo ze-atopic dermatitis ezinganeni nasezinganeni ezincane (OR = 0.42).
3. I-Neuropsychiatric Modulation
I-Gut-Brain Axis Effects: Ivula i-vagus nerve pathway, inciphisa isikhathi sokungakwazi ukubhukuda okuphoqelekile kumagundane ahlobene nokukhathazeka ngo-53%. Ukungenelela kwe-Metabolic: Ama-SCFA (ama-short-chain fatty acids) alawula ama-GABA receptors futhi athuthukise ikhwalithi yokulala kumagundane alingisa ukucindezeleka okungapheli.
4. Ukuvinjelwa Kwezifo Nokwelashwa
I-Metabolic Syndrome: Yehlisa izinga likashukela egazini ngo-1.8 mmol/L ezigulini ezinesifo sikashukela sohlobo 2 futhi yathuthukisa inkomba ye-HOMA-IR ngama-42%.
I-Adjuvant Cancer Therapy: Inhlanganisela ne-5-FU inyuse izinga lokusinda kwamagundane anomdlavuza we-colon ngo-31% futhi yehlisa ivolumu yesimila ngama-54%.
• Yini Isicelo SeI-Bifidobacterium Longum ?
I-Bifidobacterium longum yeqa imingcele evamile, yakha izindawo eziyisithupha ezinkulu zokufaka isicelo:
1. Imboni Yokudla
Imikhiqizo yobisi evutshiwe: Uma ihlanganiswa ne-Streptococcus thermophilus, inyusa i-viscosity ye-yogurt izikhathi ezingu-2.3 futhi inwebe impilo yeshalofu ibe yizinsuku ezingu-45.
Ukudla okusebenzayo: Ukwengeza i-5 × 10 ^ 9 CFU/g kuma-cereal bar kwandisa imvamisa yokunyakaza kwamathumbu kusuka ku-2.1 kuya ku-4.3 izikhathi ngesonto kubantu abanokuqunjelwa.
2. Imithi
Izidakamizwa ezithengwayo (OTC):I-Bifidobacterium longumamaphilisi amagciwane aphilayo kathathu (i-Lizhu Changle) anokuthengiswa konyaka okudlula amabhokisi ayizigidi ezingama-230 futhi asebenza ngempumelelo ngo-89% ekwelapheni isifo sohudo.
I-Biologics: Amaphilisi ezilimi ezingaphansi ahlakazeka ngokushesha akhuphula isivinini se-probiotic colonization izikhathi ezintathu futhi athole imvume ye-FDA Fast Track.
3. Ezolimo kanye nokudla
Ukufuywa kwemfuyo nezinkukhu: Ukwengeza i-1×10^8 CFU/kg yokudla kunciphisa isifo sohudo kumantshontsho engulube ngo-67% futhi kwandisa ukuguqulwa kokudla ngo-15%. Ukuvikelwa Kwezitshalo: Ukutshala i-Rhizosphere kwehlisa ubukhona begciwane likatamatisi ngo-42% futhi kwenyusa isivuno ngo-18%.
4. Izithako zezimonyo
Ukulungiswa Kwezithiyo: 0.1% ukukhishwa kwebhaktheriya kwehlise isikhumba se-TEWL (ukulahlekelwa kwamanzi e-transepidermal) ngo-38%, bathola isitifiketi se-EU ECOCERT.
Izicelo Zokulwa Nokuguga: Zihlanganisiwebifidobacteria longumngama-peptide, yehlise ukujula kwemibimbi ye-periorbital ngo-29%, yathola isitifiketi sezimonyo sokusebenzisa okukhethekile kuMnyango Wezempilo, Wezabasebenzi Nenhlalakahle Yase-Japan.
5. Ubuchwepheshe Bemvelo
Ukuhlanza Amanzi Angcolile: Ukusebenza kahle kokucekelwa phansi kwe-ammonia nitrogen okungama-78% kwafinyelelwa, kwehlisa ukukhiqizwa kodaka ngama-35%.
I-Biofuel: Ukusebenza kahle kokukhiqizwa kwe-acetic kukhuphuke kwafinyelela ku-12.3 g/L, kunciphisa izindleko ngo-40% uma kuqhathaniswa nezinqubo zendabuko.
6. Impilo Yezilwane Ezifuywayo
Ukudla Kwezilwane Ezifuywayo: Ukwengeza i-2 × 10 ^ 8 CFU/kg ekudleni kwezinja kuthuthukise amaphuzu e-fecal ngo-61% futhi kunciphise isifo sohudo.
Ukuguqulwa Kokuziphatha: Isifutho sadambisa ukukhathazeka ngokuhlukana futhi sanciphisa ukuziphatha okunolaka ngo-54%.
• Newgreen Supply High QualityI-Bifidobacterium LongumImpushana
Isikhathi sokuthumela: Jul-29-2025
