I-Andrographis Paniculata Extract: Isithako Samakhambi Esinamandla Esilwa Namagciwane Futhi Esilwa Nokuvuvukala

●Yini I-Andrographis Paniculata Extract?

I-Andrographis paniculata, eyaziwa nangokuthi "injabulo yesikhathi esisodwa" kanye "notshani obubabayo", isitshalo saminyaka yonke se-herbaceous somndeni wakwa-Acanthaceae. Idabuka eNingizimu ye-Asia njenge-India ne-Sri Lanka, futhi manje isatshalaliswa kabanzi ezindaweni ezinomswakama nezishisayo njenge-Guangdong ne-Fujian e-China. Sonke isitshalo sinambitheka ngokubaba kakhulu, sinesiqu esiyisikwele, amaqabunga aphikisanayo, nesikhathi sokuqhakaza sika-August-September. Umuthi wendabuko waseShayina usebenzisa imiphumela yawo yokususa ukushisa nokukhipha ubuthi, ukupholisa igazi nokunciphisa ukuvuvukala ukuze ukwelapha umkhuhlane, umkhuhlane, isifo sohudo, izilonda kanye nokulunywa yinyoka. Imboni yesimanje ikhipha izithako ezisebenzayo eziqwini namaqabunga ngokusebenzisa isizinda se-CO₂ esibaluleke kakhulu kanye nobuchwepheshe be-bio-enzymatic hydrolysis ukuze yenze izimpushana ezijwayelekile ezinokuqukethwe kwe-andrographolide okungu-8% -98%, ithuthukisa ukuthuthukiswa kwayo isuka emithini yesintu yesintu iye ezintweni zokusetshenziswa zamazwe ngamazwe.

Izithako ezisebenzayo eziyinhloko zeI-Andrographis Paniculata Eama-xtractsyizinhlanganisela ze-diterpenoid lactone, ezibalelwa ku-2% -5%24, ikakhulukazi okuhlanganisa:

1.  I-Andrographolide:ifomula ye-molecular C₂₀H₃₀O₅, ebalwa ku-30% -50%, iyinto eyinhloko esebenzayo ye-antibacterial and anti-inflammatory.
2.  I-Dehydroandrographolide:ifomula ye-molecular C₂₀H₂₈O₄, iphoyinti elincibilikayo 204℃, elinomsebenzi obalulekile wokulwa nesimila.
3. I-14-Deoxyandrographolide:ifomula ye-molecular C₂₀H₃₀O₄, esebenza kahle kakhulu ngokumelene ne-leptospirosis.
4. I-Neoandrographolide:ifomula ye-molecular C₂₆H₄₀O₈, ukuncibilika okuhle kwamanzi, okufanelekile ukulungiswa ngomlomo.

Ngaphezu kwalokho, ama-flavonoids, ama-phenolic acid kanye nezingxenye zamafutha aguquguqukayo athuthukisa ukusebenza kwe-antioxidant kanye ne-immunomodulatory.

●Yiziphi Izinzuzo Zazo I-Andrographis Paniculata Extract?

1. Immunomodulation And Anti-Infection

I-Antibacterial and Antiviral: I-Andrographolide inezinga lokuvinjelwa elingaphezu kuka-90% ku-Staphylococcus aureus ne-Shigella dysentery, futhi ukusebenza kahle kwayo ngokomtholampilo ekwelapheni uhudo olubangelwa yi-bacillary kuqhathaniswa ne-chloramphenicol. Ukukhishwa kwawo kwamanzi kunganciphisa izehlakalo zomkhuhlane ngama-30% futhi kufinyeze isikhathi somkhuhlane ngama-50%.

Ukuthuthukiswa Kwamasosha omzimba: Ngokuvula ama-macrophage nama-T lymphocyte, kungakhuphula izinga lama-CD4⁺ lymphocyte ezigulini ezine-HIV (idatha yomtholampilo: 405→501/mm³, p=0.002).

2. I-Anti-Tumor And Angiogenesis Inhibition

I-anti-tumor eqondile: I-Dehydroandrographolide ingavimbela ukukhula kwezimila ezitshalwe kabusha ze-W256 futhi ivimbele ukwanda kwamangqamuzana omdlavuza ngendlela encike kumthamo.

I-Anti-angiogenesis: I-Andrographolide ivimba i-angiogenesis yesimila ngokwehlisa isisho se-VEGFR2 futhi ivimbele indlela yokusayina ye-ERK/p38, nge-IC₅₀ ka-100-200μM.

3. I-Metabolism Nokuvikelwa Kwezitho

Ukuvikelwa kwesibindi nokunciphisa i-lipid: I-Andrographolide igcina amazinga e-glutathione futhi yehlisa i-malondialdehyde (MDA) kumodeli yokulimala kwesibindi ye-carbon tetrachloride ngo-40%, okungcono kune-silymarin.

Ukuvikelwa kwenhliziyo nemithambo yegazi: Ilawula ibhalansi ye-nitric oxide/endothelin, ibambezela isifo sokuqina kwemithambo yegazi, futhi yehlise izinga le-lipid yegazi konogwaja bokuhlola.

4. I-Anti-Inflammatory And Antioxidant

Ukukhishwa kwamanzi kwesiqu kunamandla amakhulu okuqothula ama-radicals mahhala (IC₅₀=4.42μg/mL), esebenza kahle izikhathi ezingu-4 kune-antioxidant yokwenziwa futhi ifanele izifo ezivuthayo ezingapheli.

●Yiziphi Izicelo ZeI-Andrographis Paniculata Extract ?

1. Imithi Nokwelashwa Kwezempilo

Imithi elwa namagciwane: isetshenziselwa uhudo lwebhaktheriya, umjovo we-pneumonia kanye namalungiselelo omlomo we-pharyngitis, ngesilinganiso sokwelapha emtholampilo esingaphezu kwama-85%.

Izidakamizwa eziqondiswe e-anti-tumor: Okuphuma ku-Andrographolide "Andrographine" kungene ezivivinyweni zomtholampilo zeSigaba II ze-leukemia nezimila eziqinile.

Ukuphathwa kwezifo ezingamahlalakhona: ukwelashwa kwe-adjuvant ye-retinopathy yesifo sikashukela (0.5-2mg/kg/ngosuku) kanye nesifo samathambo (1-3mg/kg/ngosuku).

2. Ukufuywa Kwezilwane Nokuzalanisa Okuhlaza

Eminye imithi elwa namagciwane: Izithako zokudla zeCompound Andrographis paniculata zinciphisa izinga lokuhuda kwamaphuphu futhi andise izinga lokusinda kwezinkukhu zenyama; ukungeza ukukhishwa okungu-4% kokuphakelayo kwe-carp, izinga lokuzuza isisindo lifinyelela ku-155.1%, futhi izinga lokuguqulwa kokuphakelayo lithuthukiselwe ku-1.11.

Ukuvimbela nokulawula izifo: Umjovo we-Andrographis paniculata welapha inyumoniya ezingulubeni kanye ne-enteritis, ngesilinganiso sokwelapha esingu-90% kanye nezinga lokufa elingu-10%.

3. Ukudla Kwezempilo Kanye Namakhemikhali Ansuku Zonke

Ukudla okusebenzayo: Andrographis paniculatakhiphaama-capsules (i-200mg ngosuku) ethulwa ezimakethe zaseYurophu naseMelika ukuze kulawuleke ukuzivikela komzimba kanye nokuvimbela amakhaza.

Imikhiqizo yokunakekelwa kwesikhumba: Yengeza kuma-essence eqeda ukuvuvukala kanye nama-sunscreens ukuze ukhulule umonakalo we-UV kanye nokubabomvu kwesikhumba esibucayi.

4. Ukuphumelela Ezindaweni Ezisafufusa

Imithi elwa ne-angiogenic: Ukuthuthukiswa kwamalungiselelo ahlosiwe ezimila kanye ne-diabetes retinopathy sekuyindlela eyinhloko ye-synthetic biology.

Ukunakekelwa kwempilo yezilwane ezifuywayo: Izithako ezilwa nokuvuvukala kanye ne-immunomodulatory yezinja namakati zethulwa emakethe yaseNyakatho Melika, ngezinga lokukhula lonyaka lama-35%.

●NEWGREEN SupplyI-Andrographis Paniculata ExtractImpushana