I-Albizia Bark Extract: Isithako Esisafufusa Esilwa Nethumba

●Yini? I-Albizia Bark Extract?

Amagxolo e-Albizia julibrissin amagxolo omisiwe esitshalo esimila imidumba i-Albizia julibrissin, futhi akhiqizwa kakhulu ezifundazweni ezigudle uMfula i-Yangtze njenge-Hubei, i-Jiangsu ne-Zhejiang. I-epidermis yayo imbozwe ngokuminyene ngezimbotshana ezimise okweqanda okunsundu ngokubomvu, okufana “nezigaxa zamaparele”. I-cross-section yangaphakathi ine-fibrous futhi iyaxega, inokunambitheka okune-astringent kanye nokuhlabayo. Ukuvuna nokucwecwa kwendabuko kufanele kuqedwe ehlobo nasekwindla ukuze kugcinwe ukuqina kwezithako ezisebenzayo.

Isingeniso sezithako zeUkukhishwa kwegxolo le-Albizia:

Amagxolo esihlahla sikasilika aqukethe ama-metabolites angu-1,186. Ingxenye esebenzayo eyinhloko i-triterpene saponins (ibalwa ku-15% -30% wesisindo esomile), ingezwe ngama-flavonoid, ama-lignans nama-polysaccharides.

Iphayona eliphikisayo: I-Achuan glycoside (C₅₈H₉₄O₂₆) ivimbela i-tumor neovascularization ngokuvimbela i-vascular endothelial growth factor receptor (VEGFR-2);

Isithuthukisi sokuzivikela komzimba: Ingxenye ye-polysaccharide yenza kusebenze umsebenzi we-phagocytic wama-macrophage, ithuthukisa umsebenzi we-interleukin-2 (IL-2), futhi ivimbela i-S180 sarcoma etshalwe kabusha kumagundane ngo-73%.

Izici ze-Neuroregulatory: 3 ',4', 7-trihydroxyflavonoids ilawula indlela ye-gamma-aminobutyric acid (GABA), inciphisa isikhathi sokulala samagundane emodeli yokuqwasha ngo-40%.

Ukutholwa kwe-Breakthrough: Ucwaningo lwe-2024 luqinisekisile ukuthi ingxenye engu-23 (i-ethanol reflux - i-n-butanol extract) ingabangela ukuhlanganiswa kwe-nucleus necrosis kumaseli we-tumor, futhi ubuthi bayo besibindi nezinso kumagundane aphethe isimila kuncipha ngo-50% uma kuqhathaniswa nezikhishwe zendabuko.

●ZiyiniIzinzuzoKwe I-Albizia Bark Extract?

1. I-Anti-Tumor Angiogenesis

Ukuvimbela ukufuduka kwamaseli e-endothelial e-HMEC-1 kanye nokuvimbela ukunikezwa kwezakhi kumathumba, ukuhlolwa kwangaphambi komtholampilo kubonise ukuthi indawo ye-metastatic foci yehle ngo-60%.

Uma isetshenziswa ngokuhambisana nomuthi wokwelapha ngamakhemikhali i-avastin, inganciphisa umthamo womjovo ongaphansi kwesikhumba ngo-70%, iphule ibhodlela le-oral bioavailability.

2. I-Psychoneuroregulation

Ukukhulula ukucindezeleka kanye nokuthulisa ingqondo: Ukulawula phezulu ukuvezwa kwe-5-hydroxytryptamine receptors kanye nokuthuthukisa imvamisa yemisebenzi ezenzakalelayo kumagundane ayimodeli yokukhathazeka;

I-Anticonvulsant:Ukukhishwa kwegxolo le-Albiziakunganciphisa ukujabula kwama-neurons e-glutamatergic, futhi imvamisa yokuquleka kwesifo sokuwa yehla ngo-35%.

3. Traditional Efficacy Thuthukisa

Ithumba elilwa namaphaphu: I-Quercetin 3-O-galactoside ivimbela ukwakheka kwamabhaktheriya e-septic biofilms, kanye nesici sokuvuvukala se-TNF-α esicutshini samaphaphu sehla ngo-52%.

Ukulungiswa kwe-trauma: Izingxenye ze-tannin zisebenzisa ama-osteoblasts, zikhulisa izinga lokwakheka kwe-callus kumagundane aphukile ngama-40%.

●ZiyiniIsiceloOf I-Albizia Bark Extract?

1. Inkundla yezokwelapha

Imithi eqondiswe ngesimila: Amanye amabhizinisi emithi akhuthaza ukusetshenziswa kwemithi emisha yesigaba sesihlanu semithi yendabuko yamaShayina enengxenye 23, ehloselwe ukwelapha i-glioma i-adjuvant.

Imikhiqizo yezempilo yengqondo: Ibhizinisi laseJapan lenze i-capsule eyinhlanganisela ye-Acacia glycoside ne-γ -aminobutyric acid, enenani elisebenzayo elingaphezu kwama-80% ekwenzeni ngcono ukuqwasha ngesikhathi sokunqamuka kokuya esikhathini.

2. Ukudla Okusebenzayo Nezimonyo

Isiphuzo setiye epholile:Ukukhishwa kwegxolo le-Albizia(kugxiliswe ku-10:1) kuhlanganiswe nembewu ye-jujube, ngenani lokuthenga kabusha elingu-65% esitolo esiphambili se-Tmall.

Ukunakekelwa kwesikhumba esilwa nokungezwani komzimba nezinto ezithile: Izingxenye ze-flavonoid zivimbela ukuwohloka kwamaseli e-mast. Amanye amabhizinisi ezimonyo asungule i-“Hehuan Soothing Essence”.

3. Ukuqamba Okusha Kwezolimo

Ukukhishwa okungahluziwe kwegxolo lesihlahla sikasilika, njengesibulala-zinambuzane esisekelwe esitshalweni, kunezinga lokufa elingama-92% kuma-aphid kanye nomjikelezo wokuwohloka kwezinsuku eziyi-7 kuphela.

●Ikhwalithi ephezulu ye-Newgreen Supply I-Albizia Bark ExtractImpushana