● Yiniβ-NAD ?
I-β-Nicotinamide Adenine Dinucleotide (β-NAD) iyi-coenzyme eyinhloko ekhona kuwo wonke amangqamuzana aphilayo, ene-molecular formula ye-C₂₁H₂₇N₇O₁₄P₂, kanye nesisindo samangqamuzana angu-663.43. Njengesithwali esiyinhloko sokusabela kwe-redox, ukugxila kwayo kunquma ngokuqondile ukusebenza kahle kwemetabolism yamandla eselula futhi kwaziwa ngokuthi "imali yamandla eselula".
Izici zokusabalalisa zemvelo:
Umehluko wezicubu: Okuqukethwe kumaseli e-myocardial kuphezulu kakhulu (cishe u-0.3-0.5 mM), kulandelwa isibindi, futhi kuphansi kakhulu esikhumbeni (kwehla ngo-50% njalo eminyakeni engu-20 ubudala);
Ifomu lokuba khona: kufaka phakathi ifomu eline-oxidized (NAD⁺) kanye nefomu elincishisiwe (NADH), kanye nebhalansi eguquguqukayo yesilinganiso phakathi kwalokhu kokubili kubonisa isimo semetabolism yeselula.
● Ukuvikelwa Kwemisebe yeβ-NAD.
Khulisa izinga lokusinda lamaseli e-hematopoietic stem ngemva kokuchayeka emisebeni izikhathi ezi-3, futhi uthole ukunakwa okubalulekile okuvela kuphrojekthi yezempilo yasemkhathini ye-NASA.
Umthombo wokulungiselela: Ukusuka ekukhishweni kwebhayoloji kuya kuguquko lwebhayoloji yokwenziwa
1. Indlela yendabuko yokukhipha
Izinto ezisetshenziswayo: amaseli emvubelo (okuqukethwe 0.1% -0.3%), isibindi sesilwane;
Inqubo: ukuchotshozwa kwe-ultrasonic → i-ion exchange chromatography → ukumisa iqhwa,β-NADubumsulwa ≥ 95%.
2. I-enzyme catalytic synthesis (inqubo evamile)
I-Substrate: I-Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Inzuzo: Ubuchwepheshe be-enzayimu enganyakazi bungakhuphula isivuno se-β-NAD siye ku-97%.
3. Ibhayoloji yokwenziwa (indlela yesikhathi esizayo)
I-Escherichia coli ehlelwe ngofuzo:Uhlobo olunjiniyela olwakhiwe yi-ChromaDex, e-USA, ngesivuno sokuvutshelwa okungu-6 g/L;
Isiko lamaseli ezitshalo: Uhlelo lwezimpande lukagwayi olunoboya lubona ukukhiqizwa okukhulu kwe-NAD precursor NR.
● Yiziphi izinzuzo ze-β-NAD?
1. Indlela ewumgogodla yokulwa nokuguga
Yenza kusebenze ama-Sirtuins:Khulisa umsebenzi we-SIRT1/3 izikhathi ezi-3-5, lungisa umonakalo we-DNA, futhi wandise isikhathi sokuphila imvubelo ngama-31%;
Ukunikezwa amandla kwe-Mitochondrial:Ucwaningo lwezokwelapha lubonisa ukuthi abantu abaneminyaka engu-50-70 ubudala banezela i-500 mg NMN nsuku zonke, futhi ukukhiqizwa kwe-ATP kwemisipha kukhuphuka ngo-25% ngemva kwamasonto angu-6.
2. I-Neuroprotection
Isifo i-Alzheimer's:Ukubuyisela amazinga e-neuronal NAD⁺ kunganciphisa ukufakwa kwe-β-amyloid, futhi umsebenzi wokuqonda wamamodeli wegundane uba ngcono ngo-40%;
Isifo sikaParkinson: β-NADVikela i-dopaminergic neurons ngokusebenzisa i-PARP1 inhibition.
3. Ukungenelela kwezifo ze-Metabolic
Isifo sikashukela:Thuthukisa ukuzwela kwe-insulin, ukuhlolwa kwegundane okukhuluphele kubonisa ukwehla kwe-30% kushukela wegazi;
Ukuvikelwa kwenhliziyo nemithambo yegazi:Thuthukisa umsebenzi we-endothelial, futhi unciphise indawo yama-atherosclerotic plaque ngo-50%.
● Yiziphi Izicelo Zeβ-NAD?
1. Inkambu yezokwelapha
Izidakamizwa ezilwa nokuguga: Amalungiselelo amaningi e-NMN aqinisekiswe njengezidakamizwa zezintandane yi-FDA ye-mitochondrial myopathy;
Izifo ze-Neurodeergenerative: I-NAD⁺ umjovo ofakwa emthanjeni usungene ezivivinyweni zomtholampilo zeSigaba II (izinkomba zesifo i-Alzheimer's).
2. Ukudla okusebenzayo
Izithako zomlomo: β-NADnjengoba amaphilisi e-NAD precursor (NR/NMN) anokuthengiswa konyaka okudlula i-$500 million.
Umsoco wezemidlalo:Thuthukisa ukukhuthazela kwabasubathi, futhi kukhona ezinye izithuthukisi ze-NAD emakethe ukuthuthukisa ukusebenza kwezemidlalo.
3. Emisha yezimonyo
I-anti-aging essence:0.1% -1% i-NAD⁺ eyinkimbinkimbi, ihlolwe ukunciphisa ukujula kombimbi ngo-37%;
Ukunakekelwa kwesikhumba:Yenza kusebenze ama-follicle stem cell cell, bese wengeza izithuthukisi ze-NAD ku-shampoo elwa nokulahlekelwa izinwele.
4. Ucwaningo lwezolimo nolwesayensi
Impilo yezilwane:Ukwengeza ama-precursors e-NAD ukuhlwanyela ukudla kukhulisa inani lamaphuphu ngo-15%;
Ukutholwa kwezinto eziphilayo:Isilinganiso se-NAD/NADH sisetshenziswa njengophawu lwesimo se-cell metabolic ukuze kuhlolwe umdlavuza kusenesikhathi.
●NEWGREEN Supplyβ-NADImpushana
Isikhathi sokuthumela: Jun-17-2025
