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Incazelo Yomkhiqizo
Ukwethulwa kwamaconsi e-folic acid
Amaconsi e-folic acid ayisithasiselo somsoco esine-folic acid (uvithamini B9) njengesithako esiyinhloko. I-Folic acid iyivithamini encibilikayo emanzini etholakala kakhulu emifino enamaqabunga aluhlaza, ubhontshisi, amantongomane nezinye izithelo. Idlala umsebenzi obalulekile wezinto eziphilayo emzimbeni, ikakhulukazi enqubweni yokuhlukaniswa kwamaseli kanye nokuhlanganiswa kwe-DNA.
Izithako Eziyinhloko
I-Folic acid: Ingxenye eyinhloko, ebandakanyeka ekukhuleni nasekuhlukaneni kwamaseli, ibaluleke kakhulu empilweni yabesifazane abakhulelwe kanye nezinsana.
Izinkomba
Abesifazane abakhulelwe nabesifazane abazama ukukhulelwa
Iziguli ezine-anemia
Abantu abadinga ukwandisa ukudla kwe-folic acid (njengabadla imifino)
Ukusetshenziswa
Amaconsi e-folic acid ngokuvamile athathwa ngomlomo. Ukusetshenziswa okuqondile kanye nomthamo kufanele kulandele imiyalelo yomkhiqizo noma iseluleko sikadokotela.
Amanothi
Abesifazane abakhulelwe kufanele balandele iseluleko sikadokotela wabo lapho besebenzisa izithasiselo ze-folic acid ukuze baqinisekise inani elifanele.
Abantu abangezwani ne-folic acid noma izithako zayo kufanele bakugweme ukusetshenziswa.
Uma uzwa noma yikuphi ukungakhululeki ngesikhathi sokuwusebenzisa, yeka ukuthatha umuthi futhi ufune usizo lwezokwelapha ngokushesha.
Fingqa
Amaconsi e-folic acid ayisithasiselo esibalulekile somsoco, afaneleka kakhulu abesifazane abakhulelwe kanye nabantu abadinga ukwandisa ukudla kwe-folic acid. Uma usebenzisa, kunconywa ukuthi ulandele isiqondiso sochwepheshe ukuze uqinisekise ukuphepha nokusebenza ngempumelelo.
I-COA
| Isivivinyo | Amazinga | Imiphumela | |
| Izici | Impushana ephuzi noma ewolintshi. Ayincibiliki emanzini nasezincibilikisini eziningi eziphilayo. Incibilika kuma-asidi acwebileyo nasezixazululweni ze-alkaline | Impushana ecwebezelayo ephuzi. Ayincibiliki emanzini nasezincibilikisini eziningi eziphilayo. Incibilika kuma-asidi acwebileyo nasezixazululweni ze-alkaline | |
|
Ukuhlonza (Folic Acid) | A: Ukuzungezisa okukhethekile | + 18 ukuze +22 (i-anhydrous into) | 19.2 |
| B:HPLC ama-chromatogram | Iyahambisana | Iyahambisana | |
| C: TLC Ukuhlonza | Iyahambisana | Iyahambisana | |
|
Into ehlobene | Ukungcola okungaphezu kuka-0.5% | 0.4 | |
| Ukungcola D kungabi ngaphezu kuka-0.6% | 0.5 | ||
| noma yikuphi okunye ukungcola okungadluli ku-0 5% | 0.4 | ||
| Ingqikithi yokunye ukungcola ayikho ngaphezu kuka-1 0% | 0.8 | ||
| Isilinganiso sokumuncwa kwe-UV | I-A256/A365:2.803.0 | 2.90 | |
| Ama-amines mahhala | I-NMT 1/6 | 1/7 | |
| Ukungcola okuguquguqukayo kwe-Organic | Kuyavumelana | Kuyavumelana | |
| Ubumsulwa beChromatographic | Hhayi ngaphezu kuka-2.0% | 1.74% | |
| Umlotha one-sulphate | Hhayi ngaphezu kuka-0.2% | 0. 13% | |
| Ukuhola | 2ppm Max | Kuyavumelana | |
| Impilo yeshelufu | Iminyaka emi-2 lapho igcinwe kahle | ||
| Isiphetho : Ihambisana ne-BP2002/USP28 | Isiphetho : Ihambisana ne-BP2002/USP28 | ||
Umsebenzi
Imisebenzi yamaconsi e-folic acid ikakhulukazi ihlanganisa izici ezilandelayo:
1. Thuthukisa ukuhlukana nokukhula kwamaseli:I-Folic acid iyilungu lamavithamini B. Ibandakanyeka ekuhlanganisweni kwe-DNA ne-RNA futhi ibalulekile ekuhlukaniseni okuvamile nokukhula kwamaseli, ikakhulukazi kumaseli akhula ngokushesha (njengamaseli engane).
2. Ukuvinjelwa kokukhubazeka kwe-neural tube:Ukwengezwa kwe-folic acid ngesikhathi sokukhulelwa kunganciphisa kakhulu ingozi yokukhubazeka kwe-fetus neural tube (njenge-spina bifida ne-anencephaly), ngakho-ke abesifazane abakhulelwe ngokuvamile bayelulekwa ukuthi bangezelele nge-folic acid.
3. Isekela i-erythropoiesis:I-Folic acid isiza ukwakheka kwamangqamuzana abomvu egazi futhi ivimbele i-anemia, ikakhulukazi i-megaloblastic anemia.
4. Thuthukisa Impilo Yenhliziyo: I-Folic acid isiza ukwehlisa amazinga e-homocysteine futhi ingasiza ekwehliseni ubungozi besifo senhliziyo.
5. Ithuthukisa Impilo Yengqondo:Olunye ucwaningo lubonisa ukuthi i-folic acid ingase ibe nemiphumela emihle esimweni sengqondo nempilo yengqondo futhi ingase isize ekudambiseni izimpawu zokucindezeleka.
6. Thuthukisa ukusebenza kwamasosha omzimba:I-folic acid nayo idlala indima ebalulekile ekusebenzeni okuvamile kwamasosha omzimba futhi isiza ekuthuthukiseni ukusabela komzimba komzimba.
Fingqa
Amaconsi e-folic acid ayisithasiselo esibalulekile somsoco, ikakhulukazi kwabesifazane abakhulelwe nabesifazane abahlela ukukhulelwa, okungase kusekele ukukhula okunempilo kombungu, kuvimbele ukonakala, futhi kube nezinzuzo eziningi zezempilo iyonke. Uma usebenzisa, kunconywa ukuthi ulandele isiqondiso sikadokotela ukuze uqinisekise ukuphepha nokusebenza.
Isicelo
Ukusetshenziswa kwamaconsi e-folic acid kugxilwe kakhulu kulezi zici ezilandelayo:
1. Ukunakekelwa kokukhulelwa:
Vimbela ukukhubazeka kwe-neural tube: I-Folic acid iyisakhi esibaluleke kakhulu kwabesifazane abakhulelwe ngaphambi nangesikhathi sokukhulelwa besebancane, okunganciphisa ngempumelelo ingozi yokukhubazeka kwe-fetus neural tube (njenge-spina bifida ne-anencephaly).
Khuthaza ukukhula kombungu: I-Folic acid inomthelela ekukhuleni okuvamile nokukhula kwengane, isekela ukuhlukana kwamaseli kanye nokuhlanganiswa kwe-DNA.
2. Thuthukisa i-anemia:
Ukwelashwa kwe-megaloblastic anemia: Amaconsi e-Folic acid angasetshenziswa ukwelapha i-anemia ebangelwa ukuntuleka kwe-folic acid futhi asize ukuthuthukisa impilo yegazi.
3. Impilo Yenhliziyo:
Yehlisa Amazinga e-Homocysteine: I-Folic acid isiza ukwehlisa amazinga e-homocysteine egazini, okungase kunciphise ingozi yesifo senhliziyo.
4. Isekela Amasosha omzimba:
Ithuthukisa ukusebenza kokuzivikela komzimba: I-Folic acid idlala indima ebalulekile ekuhlukaniseni amangqamuzana nasekukhuleni futhi isiza ekugcineni ukusebenza okuvamile kwamasosha omzimba.
5. Impilo Yengqondo Ethuthukisiwe:
Isekela Impilo Yesistimu Yezinzwa: I-Folic acid ibalulekile empilweni yesimiso sezinzwa futhi ingase isize ukuthuthukisa isimo sengqondo nokusebenza kwengqondo.
Ukusetshenziswa
Amaconsi e-folic acid ngokuvamile athathwa ngomlomo. Ukusetshenziswa okuqondile kanye nomthamo kufanele kulandele imiyalelo yomkhiqizo noma iseluleko sikadokotela.
Amanothi
Ngaphambi kokusebenzisa amaconsi e-folic acid, kunconywa ukuthi uthintane nodokotela, ikakhulukazi kwabesifazane abakhulelwe, abesifazane abancelisayo kanye nabantu abanezimo zempilo ezikhethekile.
Ukudla ngokweqile kwe-folic acid kungase kufihle izimpawu zokushoda kwevithamini B12, ngakho kufanele kusetshenziswe ngaphansi kokuqondisa kukadokotela.
Fingqa
Amaconsi e-Folic acid ayisithasiselo esibalulekile sokudla okunomsoco, esisetshenziswa kabanzi ekunakekelweni kokukhulelwa, ukwelashwa kwe-anemia, impilo yenhliziyo, njll. Uma usebenzisa, kunconywa ukuba ulandele isiqondiso sochwepheshe ukuqinisekisa ukuphepha nokusebenza kahle.
Iphakheji Nokulethwa
