● Kí niChenodeoxycholic Acid ?
Chenodeoxycholic Acid (CDCA) jẹ ọkan ninu awọn paati akọkọ ti bile vertebrate, ṣiṣe iṣiro 30% -40% ti bile acid eniyan, ati pe akoonu rẹ ga ni bile ti egan, ewure, elede ati awọn ẹranko miiran.
Awọn ilọsiwaju ni imọ-ẹrọ isediwon ode oni:
Supercritical CO₂ isediwon: isediwon labẹ iwọn otutu kekere ati awọn ipo titẹ giga lati yago fun awọn iṣẹku ohun elo Organic, ati pe mimọ le de diẹ sii ju 98%;
Ọna bakteria microbial: lilo awọn igara ti o ni ẹda ti ara ẹni (gẹgẹbi Escherichia coli) lati ṣajọpọ CDCA, iye owo dinku nipasẹ 40%, eyiti o ni ibamu pẹlu aṣa ti iṣelọpọ oogun alawọ ewe;
Ọna ti iṣelọpọ kemikali: lilo idaabobo awọ bi iṣaaju, o gba nipasẹ awọn aati-igbesẹ pupọ, o dara fun awọn ọja elegbogi mimọ-giga.
Ti ara ati kemikali-ini tiChenodeoxycholic Acid :
Orukọ kemikali: 3α,7a-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Ilana molikula: C₂₄H₄₀O₄
Iwọn molikula: 392.58 g/mol
Irisi: funfun kirisita lulú
Solubility: die-die tiotuka ninu omi, awọn iṣọrọ tiotuka ni ethanol, ether, chloroform
Yiyọ ojuami: 165-168 ℃
Iduroṣinṣin: ifarabalẹ si ina ati ooru, nilo lati wa ni firiji kuro ni ina (2-8℃)
● Kini awọn anfani ti awọnChenodeoxycholic Acid ?
1. Itu ti Cholesterol Gallstones
Ilana: ṣe idiwọ ẹdọ HMG-CoA reductase, dinku iṣelọpọ idaabobo awọ, ṣe igbelaruge yomijade bile acid, ati ni kutukutu tu awọn gallstones idaabobo awọ;
Data ile-iwosan: 750mg CDCA fun ọjọ kan fun awọn oṣu 12-24, oṣuwọn itu gallstone le de ọdọ 40% -70%.
2. Itoju Biliary Cholangitis akọkọ (Pbc)
Awọn oogun laini akọkọ: FDA fọwọsi Chenodeoxycholic Acid CDCA fun PBC, mu awọn afihan iṣẹ ẹdọ ṣiṣẹ (ALT/AST dinku nipasẹ diẹ sii ju 50%);
Itọju apapọ: ni idapoChenodeoxycholic Acidpẹlu ursodeoxycholic acid (UDCA), ipa ti wa ni ilọsiwaju nipasẹ 30%.
3. Ilana Awọn Arun Metabolic
Dinku awọn lipids ẹjẹ silẹ: idinku idaabobo awọ lapapọ (TC) ati lipoprotein iwuwo kekere (LDL);
Anti-diabetes: imudarasi ifamọ insulini, awọn idanwo ẹranko fihan pe suga ẹjẹ silẹ nipasẹ 20%
4. Alatako-iredodo Ati Ilana Ajẹsara
Dena ọna NF-κB ati ki o dinku itusilẹ ti awọn okunfa ipalara (TNF-α, IL-6);
Awọn idanwo ile-iwosan ti fihan pe oṣuwọn ilọsiwaju ti fibrosis ẹdọ ni awọn alaisan ti o ni arun ẹdọ ti ko ni ọti-lile (NAFLD) kọja 60%.
● Kini Awọn ohun elo tiChenodeoxycholic Acid ?
1. Medical Field
Itọju gallstone: Awọn tabulẹti CDCA (250mg / tabulẹti), iwọn lilo ojoojumọ 10-15mg / kg;
PBC itọju: awọn ipalemo agbo pẹlu UDCA (gẹgẹ bi awọn Ursofalk®), agbaye tita lododun koja US $ 500 milionu;
Iwadi egboogi-egbogi: idinaduro ilọsiwaju iṣan akàn ẹdọ nipasẹ ṣiṣe ilana awọn olugba FXR, titẹ awọn idanwo ile-iwosan Phase II.
2. Awọn ounjẹ Iṣẹ-ṣiṣe Ati Awọn ọja Ilera
Awọn tabulẹti Idaabobo ẹdọ: agbekalẹ agbo (CDCA + silymarin), idinku ibajẹ ẹdọ ọti-lile;
Awọn agunmi-sokale ọra: synergistic pẹlu jade iresi iwukara iwukara lati ṣe ilana iṣelọpọ ọra ẹjẹ.
3. Animal Husbandry Ati Aquaculture
Awọn afikun ifunni: ilọsiwaju ẹran-ọsin ati iṣelọpọ ọra adie, dinku oṣuwọn ọra inu;
Eja ilera: fifi 0.1% kunchenodeoxycholic acidlati jẹki resistance arun carp ati alekun oṣuwọn iwalaaye nipasẹ 15%.
4. Kosimetik Ati Itọju ara ẹni
Kokoro egboogi-iredodo: 0.5% -1% afikun, mu irorẹ dara ati ifamọ awọ ara;
Itọju awọ ara: ṣe idiwọ Malassezia ati dinku iran dandruff.
Lati isediwon bile ibile si iṣelọpọ microbial, chenodeoxycholic acid n ṣe iyipada lati “eroja ti ara” si “oogun to peye”. Pẹlu jinlẹ ti iwadii lori awọn arun ti iṣelọpọ ati tumo, CDCA le di ohun elo aise pataki fun itọju arun ẹdọ, awọn ounjẹ iṣẹ ṣiṣe ati awọn ohun elo biomaterials, ti o yori igbi tuntun ti ile-iṣẹ ilera 100 bilionu.
● Ipese NEWGREENChenodeoxycholic AcidLulú
Akoko ifiweranṣẹ: Jun-11-2025
