Terbinafine Hydrochloride High Purity API Material CAS 78628-80-5

Inkcazelo emfutshane:

Igama leMveliso:Terbinafine Hydrochloride

Inkcazo yeMveliso:99%

Ubomi beShelf: 24months

Indlela yokuGcina: Indawo eyomileyo epholileyo

Imbonakalo:Umgubo omhlophe

Isicelo: Ukutya / iSongezelelo / iChemical / Cosmetic

Ukupakisha: 25kg / igubu; 1kg/foil Bag okanye njengemfuno yakho

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Inkonzo ye-OEM/ODM

Iithegi zeMveliso

Ingcaciso yeMveliso

I-Terbinafine Hydrochlorideliyeza le-antifungal elisetyenziselwa ukunyanga izifo ezahlukeneyo. Ngokuqhelekileyo ikwimo yeetafile okanye iikhrimu. I-terbinafine hydrochloride liyeza elisebenzayo le-antifungal elisetyenziselwa ukunyanga izifo ezahlukeneyo zokungunda. Nokuba ijongana nonyawo lomdlali okanye usulelo lwezinzipho zokungunda, eli yeza lisebenza ngokuthintela ukuveliswa kwe-ergosterol kwaye linikezela ngeendlela ezingezihloko kunye nezomlomo zokhetho ukuze kube lula kunye nokusebenza.

I-COA

IZINTO	UMGANGATHO	ISIPHUMO SOVAVANYO
Isivavanyi	99%	Iyahambelana
Umbala	Umgubo omhlophe	Iyahambelana
Ivumba	Akukho vumba likhethekileyo	Iyahambelana
Ubungakanani besuntswana	I-100% iphumelele i-80mesh	Iyahambelana
Ilahleko ekomisweni	≤5.0%	2.35%
Intsalela	≤1.0%	Iyahambelana
Intsimbi enzima	≤10.0ppm	7ppm
As	≤2.0ppm	Iyahambelana
Pb	≤2.0ppm	Iyahambelana
Intsalela yesitshabalalisi	Ibi	Ibi
Ubalo lweepleyiti lulonke	≤100cfu/g	Iyahambelana
Igwele kunye noMngundo	≤100cfu/g	Iyahambelana
E.Coli	Ibi	Ibi
Salmonella	Ibi	Ibi
Ukuqukumbela	Qhagamshelana neNgcaciso
Ugcino	Igcinwe kwindawo epholileyo kunye neyomileyo, zigcine kude nokukhanya okuqinileyo kunye nobushushu
Beka ubomi kwishelufa	Iminyaka emi-2 xa igcinwe ngokufanelekileyo

Umsebenzi

I-1.Terbinafine hydrochloride i-synthetic allyla antifungal. Ine-lipophilic kakhulu kwindalo kwaye ithande ukuqokelela eluswini, iinzipho, kunye nezicubu ezinamafutha.

2.Terbinafine ·HCl ilungu leklasi ye-Allyl ye-antifungals, ifunyenwe inhibitor ethile ye-ergosterol synthesis nge-squalene epoxidase inhibition. I-squalene epoxidase yi-enzyme ekhutshwe yi-dermatophyte fungi ukuze iphule i-Squalene, ephazamisana nomsebenzi we-cell membrane kunye ne-wall synthesis.

I-3.I-Terbinafine hydrochloride inefuthe le-fungicidal kwi-fungi yesikhumba kunye ne-inhibitory effect kwi-Candida albicans. Ilungele ukusuleleka kwesikhumba kunye nezikhonkwane ezibangelwa ngumngundo ongaphezulu, njengombungu, intshulube yomzimba, intshulube yefemur, irherho leenyawo, intshulube yezikhonkwane kunye nosulelo lweCandida albicans lwesikhumba olubangelwa yiTrichophyton rubrum, Microsporum canis kunye neFlocculus epidermidi.

Isicelo

I-Terbinafine hydrochloride ngumgubo omhlophe wekristale ococekileyo onyibilikayo ngokukhululekileyo kwi-methan kunye ne-dichlorome, enyibilikayo kwi-ethanol, kwaye inyibilika kancinane emanzini. Njengezinye ii-allylamines, i-terbinafine inqanda ukuhlanganiswa kwe-ergosterol ngokuthintela i-squalene epoxidase,

i-enzyme eyinxalenye ye-fungal cell membrane synthesis pathway. Ngenxa yokuba i-terbinafine ithintela ukuguqulwa kwe-squalene kwi-lanosterol, i-ergosterol ayinakwenziwa. Oku kucingelwa ukuba ukutshintsha inwebu yeseli permeability, okubangela fungal cell lysis.
1. I-Terbinafine Hcl isebenza kakhulu kwiqela le-dermatophyte yefungi.
2. Njenge-1% yekhrimu okanye umgubo, isetyenziselwa ukusuleleka kolusu oluphezulu olufana nejock itch (tinea cruris),

unyawo lwembaleki (tinea pedis), kunye nezinye iintlobo zombungu (tinea corporis). I-Terbinafine cream isebenza malunga nesiqingatha sexesha elifunekayo

ngamanye amayeza e-antifungal.

3. Amacwecwe omlomo angama-250mg ahlala emiselwe unyango lwe-onychomycosis, usulelo lwe-fungal nail, ngokuqhelekileyo yidermatophyte.

okanye iintlobo zeCandida. Usulelo lwezikhonkwane lwefungal lubekwe nzulu phantsi kwesikhonkwane kwi-cuticle apho unyango olusetyenziswa ngokwezihloko

azikwazi ukungena ngezixa ezaneleyo. Iipilisi zinokuthi, ngokungaqhelekanga, zibangele i-hepatotoxicity, ngoko izigulane ziyaxwayiswa ngale nto kwaye

inokujongwa ngovavanyo lokusebenza kwesibindi. Iindlela ezizezinye zolawulo lomlomo ziye zaphononongwa.

4. I-Terbinafine isenokubangela okanye yenza mandundu ngakumbi i-lupus erythematosus ye-cutaneous. Abantu abane lupus erythematosus kufuneka

baqale baxoxe ngeengozi ezinokwenzeka nogqirha wabo phambi kokuba baqalise ngonyango.