● Yintoniβ-NAD ?
I-β-Nicotinamide Adenine Dinucleotide (β-NAD) i-coenzyme ephambili ekhoyo kuzo zonke iiseli eziphilayo, kunye ne-molecular formula ye-C₂₁H₂₇N₇O₁₄P₂, kunye ne-molecular weight of 663.43. Njengomthwali ophambili wokuphendula kwe-redox, ugxininiso lwayo lumisela ngokuthe ngqo ukusebenza kwemetabolism yamandla eselula kwaye yaziwa ngokuba "yimali yamandla eselula".
Iimpawu zokusasaza kwendalo:
Ukwahlukana kwezicubu: Umxholo kwiiseli ze-myocardial ziphezulu (malunga ne-0.3-0.5 mM), zilandelwa nesibindi, kunye neyona nto iphantsi kwesikhumba (iyancipha nge-50% yonke iminyaka engama-20 ubudala);
Ifom ekhoyo: kubandakanywa ifom ye-oxidized (NAD⁺) kunye nefom encitshisiweyo (i-NADH), kunye ne-balance balance of ratio phakathi kwezi zibini ibonisa imeko ye-cell metabolism.
● UKhuseleko kwiRadi yeβ-NAD.
Ukwandisa izinga lokusinda kweeseli ze-hematopoietic stem emva kokuvezwa kwemitha ngamaxesha e-3, kwaye ufumane ingqalelo ephambili kwiprojekthi yezempilo yendawo ye-NASA.
Umthombo wokulungiselela: Ukusuka kwi-biological extraction ukuya kwi-synthetic biology revolution
1. Indlela yotsalo lwemveli
Izinto ezibonakalayo: iiseli zegwele (umxholo 0.1% -0.3%), isibindi sesilwanyana;
Inkqubo: ukutyunyuzwa kwe-ultrasonic → i-ion exchange chromatography → ukumisa umkhenkce,β-NADubunyulu ≥ 95%.
2. I-enzyme catalytic synthesis (inkqubo eqhelekileyo)
I-Substrate: I-Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
I-advanteji: Iteknoloji ye-enzyme engashukumiyo inokunyusa isivuno se-β-NAD ukuya kwi-97%.
3. Ibhayoloji yeSynthetic (ulwalathiso lwexesha elizayo)
Escherichia coli ehlelwe yiGene:Ubunzima obuyinjineli obakhiwe yiChromaDex, eU.SA, kunye nesivuno sokubiliswa kwe-6 g/L;
Inkcubeko yeseli yezityalo: Inkqubo yengcambu yecuba enoboya iyayiqonda imveliso enkulu ye-NAD precursor NR.
● Ziziphi iingenelo zeβ-NAD?
1. Indlela engundoqo yokulwa nokuguga
Vula iiSirtuins:Ukwandisa umsebenzi we-SIRT1 / 3 ngamaxesha angama-3-5, ukulungisa umonakalo we-DNA, kunye nokwandisa ubomi bemvubelo nge-31%;
Ukuxhotyiswa kweMitochondrial:Izifundo zeklinikhi zibonisa ukuba abantu abaneminyaka eyi-50-70 ubudala bongezelela i-500 mg NMN imihla ngemihla, kunye nokuveliswa kwe-ATP ye-muscle inyuka nge-25% emva kweeveki ze-6.
2. I-Neuroprotection
Isifo sika-Alzheimer:Ukubuyisela amanqanaba e-neuronal NAD⁺ kunokunciphisa i-β-amyloid deposition, kwaye umsebenzi wokuqonda wemodeli yemouse uphucula nge-40%;
Isifo sikaParkinson: β-NADKhusela i-dopaminergic neurons ngokusebenzisa i-PARP1 inhibition.
3. Ukungenelela kwisifo se-Metabolic
Isifo seswekile:Ukwandisa uvakalelo lwe-insulin, iimvavanyo zegundane ezityebileyo zibonisa ukuncipha kwe-30% kwishukela legazi;
Ukhuseleko lwentliziyo:Ukuphucula umsebenzi we-endothelial, kwaye unciphise indawo ye-atherosclerotic plaques ngama-50%.
● Zithini izicelo zeβ-NAD?
1. Intsimi yezonyango
Amachiza okuguga: Amalungiselelo amaninzi e-NMN aqinisekisiwe njengeziyobisi zeenkedama yi-FDA ye-mitochondrial myopathy;
Izifo ze-Neurodeergenerative: I-NAD⁺ inaliti ye-intravenous ingene kwiSigaba II solingo lwezonyango (izibonakaliso ze-Alzheimer's disease).
2. Ukutya okusebenzayo
izongezo zomlomo: β-NADnjenge-NAD precursor (NR/NMN) ii-capsules zineentengiso zonyaka ezidlula i-500 yezigidi zeedola.
Isondlo sezemidlalo:Phucula unyamezelo lweembaleki, kwaye kukho ezinye ze-NAD optimizers kwimarike ukuphucula ukusebenza kwezemidlalo.
3. I-Cosmetic innovation
Undoqo wokuchasana nokuguga:I-0.1% -1% i-NAD⁺ eyinkimbinkimbi, ivavanywe ukunciphisa ubunzulu bemibimbi nge-37%;
Ukhathalelo lwentloko:Yenza kusebenze iiseli ze-follicle stem zeenwele, kwaye wongeze izixhasi ze-NAD kwishampu yokulwa nokulahleka kweenwele.
4. Uphando lwezoLimo nolwenzululwazi
Impilo yezilwanyana:Ukongeza i-NAD precursors ekuhlwayeleni ukutya kwandisa inani lamantshontsho eehagu nge-15%;
Ukufunyanwa kwebhayoloji:Umlinganiselo we-NAD/NADH usetyenziswa njengophawu lwemeko ye-cell metabolic kuvavanyo lomhlaza kwangethuba.
●Unikezelo ENTSHAβ-NADUmgubo
Ixesha lokuposa: Jun-17-2025
