I-Zinc Pyrithione (ZPT): I-Multi-Domain Fungicide

 

●Yintoni i Zinc Pyrithione?

I-Zinc pyrithione (ZPT) yi-organic zinc complex kunye ne-molecular formula ye-C₁₀H₈N₂O₂S₂Zn (i-molecular weight 317.7). Igama layo livela kwiingcambu zendalo zezityalo ze-Annaceae plant Polyalthia nemoralis, kodwa ishishini lanamhlanje liye lamkela ukuhlanganiswa kweekhemikhali ukuyivelisa. Ngo-2024, inkqubo ye-patent yase-China yagqabhuka kwi-bottleneck yococeko, kwaye ubumdaka be-crotonic acid yalawulwa ngaphantsi kwe-16ppm nge-methanol-acetone graded crystallization, kwaye ukucoceka kwebakala leyeza lonyuswa ukuya kwi-99.5%.

 

Iimpawu zomzimba kunye neekhemikhali:

Ukubonakala kunye ne-solubility: umhlophe ukuya kwi-crystalline powder encinci, ephantse ingabikho emanzini (<0.1g / 100mL), i-soluble kancinane kwi-ethanol, i-solubility kwi-polyethylene glycol inokufikelela kwi-2000mg / kg;

Ukungaphumeleli kokuzinza: ubuthathaka ekukhanyeni kunye ne-oxidants, ukuthotywa ngokulula kukukhanya kwe-ultraviolet, ukupakishwa okumdaka okufunekayo; ukungaphumeleli kwe-disociation kwi-pH <4.5 okanye> 9.5, i-pH efanelekileyo yi-4.5-9.5;

Indawo ebalulekileyo yokubola kwe-Thermal: izinzile kwiiyure ze-120 kwi-100 ℃, kodwa ibola ngokukhawuleza ngaphezu kwe-240 ℃;

Ukungahambelani: i-precipitates kunye ne-cationic surfactants, i-chelates kunye ne-discolors nge-iron / ion zethusi (nokuba i-1ppm inokubangela ukuba umkhiqizo ube phuzi).

 

●Yintoni naIingeneloKwe Zinc Pyrithione ?

I-ZPT ifezekisa inzala ebanzi (esebenzayo ngokuchasene neentlobo ze-32 ze-microorganisms) ngokusebenzisa indlela yokutshintshiselana nge-ion ekhethekileyo, ngakumbi i-Malassezia, i-culprit ye-dandruff, ene-MIC ephantsi njenge-8ppm:

 

1. Ukutshatyalaliswa kwe-Ion Gradient

Kwimeko ye-acidic, i-H⁺ ifaka igalelo kwibhaktheriya kwaye i-K⁺ iphuma, kwaye kwindawo ye-alkaline, i-Na⁺/Mg²⁺ ithathelwa indawo, echitha inkqubo yokuthutha izondlo ze-microbial;

 

2. Ukuqhekeka kweMembrane yeSeli

Ukufaka kwi-phospholipid bilayer, ukwandisa ukugqithiswa kwe-membrane kunye nokubangela ukuvuza kwezinto ze-intracellular;

 

3. Uthintelo loMsebenzi we-Enzyme

Ukuthintela ikhonkco lokuthutha i-electron kunye nokuvimbela i-enzymes eziphambili ze-metabolism yamandla (njenge-ATP synthase).

 

Ukuqinisekiswa kweklinikhi: Emva kokusebenzisa ishampu ene-1.5%zincpiyrithionekwiiveki ezi-4, i-dandruff iyancipha ngama-90%, kwaye izinga lokuphindaphinda kwe-seborrheic dermatitis liyancipha ngama-60%.

 

 

●Yintoni naIsiceloOf Zinc Pyrithione?

1. Ummandla weMichiza yosuku:

Ingasetyenziselwa kwi-70% ye-shampoo ye-anti-dandruff, kunye nenani elongezelelweyo le-0.3% -2%;

 

Ezinye iimveliso zokuthambisa zinokuthintela ukusetyenziswa kwe-zinc pyrithione kwaye kufuneka ziphawulwe "ukuhlanjululwa emva kokusetyenziswa". Ungasebenzisa enye imveliso piroctone ethanolamine (OCT).

 

2. I-Industrial Anti-Corrosion:

I-Anti-fouling revolution: idityaniswe ne-cuprous oxide ukuthintela ukunamathela kwe-barnacle kunye nokunciphisa ukusetyenziswa kwamafutha enqanawa nge-12%;

 

3. EzoLimo kunye neMathiriyeli:

Ukukhuselwa kwembewu: I-0.5% ye-agent egqumayo ikhusela ukungunda kwaye inyusa izinga lokuntshula nge-18%;

 

I-Antibacterial fiber: ilaphu le-polyester elimiliselweyo linezinga lokulwa neebhaktiriya elingaphezulu kwama-99%.

 

4. Ulwandiso lwezonyango:

Uvavanyo lwezizathu ezintathu ezingalunganga (akukho carcinogenicity/teratogenicity/mutagenicity), esetyenziselwa ijeli yamaqhakuva kunye nokwaleka kwe-antibacterial kwizixhobo zonyango.

 

●Iingcebiso:

Nangona ityhefu yomlomo ebukhaliof zinc pyrithioneiphantsi (LD₅₀>1000mg/kg kwiimpuku), izilumkiso zeklinikhi kwiminyaka yakutshanje:

 

Ubuthi bolusu: ukudibana kwexesha elide kubangela i-alergic dermatitis, kwaye ukudibana kwenkophe kunokubangela i-conjunctivitis;

 

Ukuchasana ngokupheleleyo:

→ Ulusu oluphukileyo (ukungena kwamanzi kwandisa amaxesha ama-3, okubangela ukuvezwa kwenkqubo);

→ Abasetyhini abakhulelweyo nabantwana (idatha yesithintelo segazi ebuchotsheni ayikho);

 

Ukusebenzisana kweziyobisi: Gwema ukusetyenziswa okudibeneyo kunye ne-EDTA (i-chelating zinc ions inciphisa ukusebenza kweziyobisi).

 

●ENTSHA Unikezelo lomgangatho ophezuluZinc PyrithioneUmgubo