I-Thiamine hydrochloride: Izibonelelo, ukusetyenziswa kunye nokunye

● YintoniThiamine Hydrochloride ?

I-Thiamine hydrochloride yifom ye-hydrochloride ye-vitamin B₁, kunye ne-chemical formula C₁₂H₁₇ClN₄OS·HCl, ubunzima be-molecular 337.27, kunye nenombolo ye-CAS 67-03-8. Ngumgubo wekristale omhlophe ukuya kutyheli-mhlophe kunye nevumba lebran yerayisi kunye nencasa ekrakra. Kulula ukufunxa umswakama kwimeko eyomileyo (inokuthi ithathe i-4% yomswakama xa ibonakaliswe emoyeni). Iipropati eziphambili zomzimba kunye neekhemikhali ziquka:

Ukunyibilika:Inyibilika kakhulu emanzini (1g/mL), inyibilika kancinane kwi-ethanol kunye ne-glycerol, kwaye ayinyibiliki kwizinyibilikisi zendalo ezifana ne-ether ne-benzene. 

Uzinzo:Izinzile kwindawo ene-acidic (pH 2-4) kwaye inokumelana nokushisa okuphezulu kwe-140 ° C; kodwa ibola ngokukhawuleza kwizisombululo ezingathathi hlangothi okanye ze-alkaline kwaye zingasebenzi lula ngemisebe ye-ultraviolet okanye i-redox agents.

Iimpawu zokufunyanwa:Isabela nge-cyanide yeferric ukuvelisa into eblue fluorescent "thiochrome", ethi ibe sisiseko sohlalutyo lobungakanani38.

Inkqubo yokulungiswa kwehlabathi jikelele yi-chemical synthesis, esebenzisa i-acrylonitrile okanye i-β-ethoxyethyl propionate njengezinto eziluhlaza kwaye iveliswa nge-condensation, i-cyclization, ukutshintshwa kunye namanye amanyathelo, ngokucoceka okungaphezulu kwe-99%.

●Ziziphi iiNzuzo zeThiamine Hydrochloride ?

I-Thiamine hydrochloride iguqulwa ibe yindlela esebenzayo ye-thiamine pyrophosphate (TPP) emzimbeni womntu, kwaye idlala imisebenzi emininzi ye-physiological:

1. Undoqo wemetabolism yamandla:njenge-coenzyme ye-α-ketoacid decarboxylase, ithatha inxaxheba ngokuthe ngqo kwinkqubo yokuguqulwa kwe-glucose kwi-ATP. Xa intsilelo, ikhokelela ekuqokeleleni kwepyruvate, okubangela i-lactic acidosis kunye nengxaki yamandla.

2. Ukhuseleko lweNervous System:Ukugcina ukuqhuba okuqhelekileyo kweempembelelo ze-nerve. Ukusilela okumandla kubangela i-beriberi, eneempawu eziqhelekileyo ezibandakanya i-peripheral neuritis, i-muscular atrophy, kunye nokusilela kwentliziyo. Ngokwembali, ibangele ubhubhani omkhulu e-Asia, ebulala amakhulu amawaka abantu ngonyaka.

3. Ixabiso lophando olukhulayo:

Ukhuseleko lweMyocardial:I-concentration ye-10μM inokuchasana nomonakalo we-acetaldehyde-induced myocardial cell, inhibit caspase-3 activation, kunye nokunciphisa iprotein carbonyl formation.

I-Anti-neurodegeneration:Kwiimvavanyo zezilwanyana, ukunqongophala kunokukhokelela ekuqokeleleni okungaqhelekanga kweprotheni ye-β-amyloid kwingqondo, ehambelana ne-pathology ye-Alzheimer's disease.

Amaqela asemngciphekweni omkhulu wokusilela aquka:ukusetyenziswa ixesha elide irayisi emhlophe esulungekileyo kunye nomgubo, utywala (i-ethanol inqanda ukufunxwa kwe-thiamine), abafazi abakhulelweyo, kunye nezigulane ezinesifo sohudo esingapheliyo.

●Yintoni usetyenziso lweThiamine Hydrochloride ?

1. Ishishini lokutya (esona sabelo sikhulu):

Izixhasi zezondlo:yongezwa kwiimveliso zecereal (3-5mg/kg), ukutya kweentsana (4-8mg/kg), kunye neziselo zobisi (1-2mg/kg) ukwenza ukulahleka kwezondlo ezibangelwa kukulungiswa kakuhle.

Imingeni yobuchwephesha:Ngenxa yokuba kulula ukubola kwindawo yealkaline, izinto eziphuma kuzo ezifana nethiamine nitrate zihlala zisetyenziswa njengeendawo zokutya okubhakiweyo.

2. Indawo yezonyango:

Usetyenziso lonyango:iinaliti zisetyenziselwa unyango olungxamisekileyo lwe-beriberi (i-neurological / heart failure), kunye namalungiselelo omlomo asetyenziswa njengonyango oluncedisayo lwe-neuritis kunye ne-indigestion.

Unyango oludityanisiweyo:zidibaniswe ne-magnesium agents ukuphucula ukusebenza kwe-Wernicke encephalopathy kunye nokunciphisa izinga lokuphindaphinda.

3. Ezolimo kunye ne-biotechnology:

Izinto ezibangela ukuxhathisa isifo sezityalo:Ukunyangwa kwe-50mM yoxinaniso lwerayisi, ukhukhamba, njl., kusebenze iijene ezinxulumene ne-pathogen (i-PR genes), kwaye iphakamisa ukuchasana nefungi kunye neentsholongwane.

Izongezo zokutya:Ukuphucula ukusebenza kakuhle kwemetabolism yeswekile kwimfuyo kunye neenkukhu, ngokukodwa kwiindawo ezixinzelelekileyo zokushisa (ukwanda kwemfuno yokukhupha i-sweat).

● Unikezelo OLUTSHA Umgangatho ophezuluThiamine HydrochlorideUmgubo