• Yintoni iI-TUDCA ?
Ukugqatswa lilanga ngoyena nobangela wemveliso yemelanin. Imitha yeultraviolet ekukhanyeni kwelanga yonakalisa i-deoxyribonucleic acid, okanye i-DNA, kwiiseli. I-DNA eyonakeleyo inokukhokelela kumonakalo kunye nokuchithwa kolwazi lwemfuza, kwaye kubangele utshintsho olubi lwemfuza, okanye ilahleko yemfuza ye-tumor suppressor, ekhokelela ekuveleni kwamathumba.
Nangona kunjalo, ukukhanya kwelanga "akubi kakhulu", kwaye konke oku "ityala" kwi-melanin. Enyanisweni, ngexesha elinzima, i-melanin iya kukhutshwa, ibambe ngokufanelekileyo amandla emitha ye-ultraviolet, ukukhusela i-DNA ukuba ingonakaliswe, ngaloo ndlela inciphisa umonakalo obangelwa yimisebe ye-ultraviolet emzimbeni womntu. Nangona i-melanin ikhusela umzimba womntu kumonakalo we-ultraviolet, inokwenza ulusu lwethu lube mnyama kwaye luphuhlise amabala. Ke ngoko, ukuthintela ukuveliswa kwe-melanin yindlela ebalulekileyo yokwenziwa mhlophe kwesikhumba kwishishini lobuhle.
• Ziziphi iingeneloI-TUDCAkuncediso lwezemidlalo ?
Inzuzo ephambili ye-TUDCA kukuphucula impilo yesibindi kunye nomsebenzi. Izifundo zikhankanya iziphumo ezinomdla zokunciphisa i-enzymes yesibindi emva kokuxhaswa kwe-TUDCA. I-enzymes yesibindi ephakanyisiweyo ibonisa impilo embi yesibindi kunye nomsebenzi, ngelixa i-enzymes yesibindi ephantsi ibonisa impilo yesibindi esiqhelekileyo kunye nomsebenzi. Ukongezwa kunye ne-TUDCA kubonise ukunciphisa okubalulekileyo kwi-enzyme ephambili yesibindi, emele ukuphuculwa kwempilo yesibindi.
Olu phuculo kwimpilo yesibindi yintoni eyenza i-TUDCA ibe nefuthe kakhulu kubasebenzisi bezinto ze-anabolic, ngokukodwa izinto zomlomo ze-anabolic. Ezi zinto zinokuba nefuthe elikhulu kwimpilo yethu yesibindi kunye nomsebenzi, kwaye ukuthatha izongezo zenkxaso yomjikelo zihlala zinconywa ngaphezu kovavanyo lwegazi oluqhelekileyo ukujonga impilo. I-TUDCA ithathwa njengenye yezongezo zezempilo zesibindi ezikhoyo namhlanje.
I-TUDCAiyakwazi ukukhusela i-mitochondria kumalungu eselula anokuthi abangele oku kuphazamiseka, ngaloo ndlela athintele i-apoptosis. Ikwenza oku ngokuthintela imolekyuli ebizwa ngokuba yiBax ukuba ingathuthwa isiwe kwimitochondria. Xa i-Bax idluliselwa kwi-cytosol ukuya kwi-mitochondria, iphazamisa i-membrane ye-mitochondrial, eqalisa le ngqungquthela yeziganeko. Ngokuvimba i-Bax nge-TUDCA, iya kuthintela ukuhlanganiswa kwe-membrane yeseli, ethi emva koko ithintele ukukhululwa kwe-cytochrome c, enokuthi ithintele i-mitochondria ekusebenziseni i-caspases. I-TUDCA ikhusela ukufa kweeseli ngokukhusela inwebu ye-mitochondrial yeseli.
I-TUDCA ikhusela ukufa kweeseli ngokukhusela inwebu ye-mitochondrial yeseli kwizinto eziyingozi. Le nkqubo kunye nempendulo yomzimba kutheni uphando lujonge kwiinzuzo zokuncedisa i-TUDCA kubantu abaneengxaki ze-neurological ezifana ne-Parkinson's, i-Huntington's, i-Alzheimer's, kunye nezigulane ze-ALS. Iziphumo zezi zifundo kunye neengcebiso zakwangoko zivuyisa kakhulu. I-TUDCA inokuba neziphumo eziluncedo kakhulu kwinani lezifo ezikhulu.
Uphando luye lwabonisa ukuba i-TUDCA iphucula ukuzwela kwe-insulin kwi-muscle kunye nesibindi, kwaye inefuthe elihle kwimpilo ye-thyroid.
• KagakananiI-TUDCAkufuneka ithathwe?
Iindidi zeedosi ziye zafundiswa ngezibonelelo zeTUDCA. Ukuqala nge-10-13 mg ye-TUDCA yokuncedisa ngosuku, izigulane ezinezifo ezingapheliyo zesibindi zifumana ukunciphisa okukhulu kwi-enzyme yesibindi kwiinyanga ze-3. Amanani ukuya kuthi ga kwi-1,750 mg ngosuku abonakaliswe ukuba luncedo kwisifo sesibindi esinamafutha kunye nokuphucula i-muscle kunye ne-insulin yesibindi. Izilwanyana eziphononongwayo zibonise iidosi ukuya kwi-4,000 mg (umntu olinganayo) waba nefuthe elihle kwi-neuroprotection ukusuka ekulahlekeni kweememori ezinxulumene neminyaka.
Nangona le milinganiselo eyingozi kakhulu, phakathi kwe-500 mg kunye ne-1,500 mg ngosuku kubonakala ngathi idosi efanelekileyo yokuvelisa iziphumo ze-TUDCA. Uninzi lwezongezelelo lubonakala luqulunqwe ukuba luqulathe i-100 - 250 mg ye-TUDCA ngokukhonza, ukuba ithathwe ngamaxesha amaninzi ngosuku. Njengoko zininzi zezi zithako, uphando oluninzi luyafuneka ukuze ufumane amanani athile.
• Kufuneka niniI-TUDCAkuthatyathwe?
I-TUDCA inokuthatyathwa nangaliphi na ixesha losuku, kwaye ithathwa ngokufanelekileyo ngokutya ukunceda ukufunxa. Njengoko kukhankanyiwe ngasentla, ezininzi izongezo zifakwe kwi-100 - 250 mg ngokukhonza. Kunconywa ukuba usasaze umthamo we-TUDCA yonke imini, uyithatha i-2, i-3, i-4 okanye amaxesha angama-5 ngosuku.
• Ithatha ixesha elingakanani ukuba iTUDCA isebenze?
I-TUDCA ayisebenzi ngobusuku. Izifundo ziye zabika iziphumo ezahlukeneyo ze-TUDCA emva kwe-1, i-2, i-3 okanye iinyanga ze-6 zokuncedisa. Ukususela kuphando olukhoyo, kukhuselekile ukuthetha ukuba ubuncinane iintsuku ze-30 (inyanga ye-1) yokuncedisa iyadingeka ukuze ubone ukuphuculwa kunye neenzuzo. Nangona kunjalo, ukusetyenziswa okuqhubekayo kunye nexesha elide kuya kuvelisa izibonelelo ezinkulu zokuncedisa nge-TUDCA.
Ixesha lokuposa: Dec-06-2024
