I-Sodium 3-Hydroxybutyrate : Izibonelelo, izicelo kunye nokunye

●Yintoni i Isodium 3-Hydroxybutyrate ?

I-sodium 3-hydroxybutyrate (i-sodium β-hydroxybutyrate, i-BHB-Na) yinto ephambili ye-ketone body metabolism. Ikhona ngokwemvelo egazini kunye nomchamo, ngakumbi kwimeko yendlala okanye i-carbohydrate ephantsi. Ukulungiswa kwendabuko kusekelwe kwi-hydrolysis ye-3-hydroxybutyric acid esters (methyl ester / ester ester) kunye ne-sodium hydroxide, kodwa idinga i-organic solvent recrystallization, ekhokelela kwinkqubo eyinkimbinkimbi, ukufunxa lula umswakama kunye ne-agglomeration yeemveliso, kunye ne-solvents eseleyo inokuchaphazela ukhuseleko lwezicelo zonyango.

Okwangoku, ezinye iinkampani ziye zenza inkqubela phambili kwinkqubo yokwenziwa kwezinto ezintsha: ukungcola kwe-crotonic acid kulawulwa ngaphantsi kwe-16ppm nge-methanol-acetone fractional crystallization method, kwaye ukuhlambuluka kunyuswe kwi-99.5%, ehambelana nomgangatho we-injection;

Itekhnoloji ye-crystallization yenyathelo elinye lokumisa isitshizi isebenzisa i-160 ℃ umoya oshushu ukuguqula ngokuthe ngqo ulwelo olusabelayo lube ziikristale ezingqukuva, ezinemveliso yemveliso engaphezulu kwe-95%. I-X-ray diffraction spectrum ibonisa iimpawu ze-17 (2θ = 6.1 °, 26.0 °, njl.), kunye nokuzinza kwesakhiwo se-crystal ngamaxesha e-3 ngaphezu kwenkqubo yendabuko, eyisombulula ngokupheleleyo ingxaki yokufunxa umswakama.

●Yintoni naIingeneloKwe Isodium 3-Hydroxybutyrate ?

Njenge "imolekyuli ephezulu yamafutha", i-sodium 3-hydroxybutyrate inika amandla ngokuthe ngqo kwisithintelo segazi-ingqondo, kwaye indlela yayo yezendalo iye yaphononongwa ngokunzulu kwiminyaka yakutshanje:

Ummiselo weMetabolic:Kwimodeli yesifo seswekile, iphucula ubuntununtunu kwi-insulin. I-dose enye (i-0.2 mg / kg) inokunyusa izinga le-glycogen yesibindi se-synthesis nge-40%;

Ukhuseleko lweNeuro:Izifundo ziye zafumanisa ukuba i-derivative yayo ye-3-hydroxybutyrate methyl ester ingenza i-L-type calcium channels isebenze, ikhulise i-calcium ion concentration kwiiseli ze-glial nge-50%, kwaye inqanda i-apoptosis ye-cell nge-35%, inika indlela entsha yonyango lwe-Alzheimer's;

I-Anti-Inflammatory kunye ne-Antioxidant:Ngokunciphisa i-lipid peroxides kunye neentlobo ze-oksijeni ezisebenzayo (i-ROS), ikhulula ukuvuvukala kwemisipha emva kokuzivocavoca, kunye nokusebenza kokunyamezela kwabadlali kuphucula nge-22% emva kokuxhaswa.

●Yintoni naIsiceloKweIsodium 3-Hydroxybutyrate ?

1. Umzi mveliso wezempilo: uMthwali onguNdoqo woQoqosho lweKetogenic

Ukulawulwa kobunzima: njengeyona nto iphambili yezongezelelo ze-ketogenic, ivuselela ukusebenza kakuhle kwe-ketogenic yesibindi.

Isondlo sezemidlalo: iziselo ze-electrolyteIsodium 3-Hydroxybutyrateidibaniswe ne-branched-chain amino acids inokugcina i-ketone concentrations yegazi ngaphezu kwe-4mM emva kokuzivocavoca kunye nokunciphisa ixesha lokubuyisela imisipha nge-30%.

2. Intsimi yezoNyango: Ithemba elitsha leZifo ze-Neurodeergenerative

Ukunyangwa kwe-adjuvant ye-epilepsy: idibaniswe ne-anticonvulsants inokunciphisa ukuphindaphinda kwe-seizure ngama-30%, kwaye izilingo zeklinikhi zesigaba se-III ziye zaqaliswa;

Inkqubo yonikezelo ekujoliswe kuyo: I-Cy7 fluorescent probes ebhalwe phantsi iphumelele kwi-vivo tracing, kunye ne-infrared imaging ekufutshane ibonisa ukuba ityetyiswe kwi-hippocampus ngaphakathi kweeyure ze-2, inikezela ngomthwalo wolawulo lweziyobisi zengqondo.

3. ISayensi yeMathiriyeli: ISitshixo sebhayoloji ukuQhosha ungcoliseko oluMhlophe

Iiplastiki ze-Biodegradable: I-Copolymerized nge-polyester enevumba elimnandi ukwenza i-PHB (i-poly 3-hydroxybutyrate), ene-melting point ye-175 ° C kunye ne-oxygen permeability ye-1/10 kuphela ye-PET. Ingonakaliswa ngokupheleleyo kumhlaba we-anaerobic kwiintsuku ezingama-60. I-Guangdong Yuanda New Materials Co., Ltd. iphumelele imveliso yobuninzi bomgangatho woshishino;

Ukutshatyalaliswa kwefilimu yezolimo: I-PE mulch ene-5% ye-sodium 3-hydroxybutyrate eyongeziweyo, elahlekelwa iimpawu zayo zomatshini ngokukhawuleza emva kokusetyenziswa, kwaye ayinayo i-microplastic residus emva kokudibanisa.

●ENTSHA Unikezelo lomgangatho ophezuluIsodium 3-Hydroxybutyrate Umgubo