●YintoniSclareol ?
I-Sclareol, igama lekhemikhali (1R, 2R,8aS) -decahydro-1- (3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, i-molecular formula C₂₀H₃₆O₂, ubunzima bemolekyuli 308.350-309-307-CAS 308.25-301-308. Yikhompawundi ye-bicyclic diterpenoid, enenkangeleko yomgubo omhlophe wekristale, indawo yokunyibilika i-95-105℃, indawo yokubilisa i-398.3℃, enganyibiliki emanzini, kwaye inyibilika ngokulula kwizinyibilikisi zendalo. Olona phawu lwayo kukuba inevumba elihlala ixesha elide elifana ne-ambergris, enevumba elithozamisayo kunye nokusasazwa okunamandla, oko kuyenza ibe yeyona nto ilungileyo yokwenza iziqholo eziphezulu.
Umthombo wendalo ubukhulu becala i-inflorescence kunye neziqu kunye namagqabi esityalo saseLamiaceae iSalvia Sclarea L., ehlakulwa kwinqanaba elikhulu kwiindawo eziphakamileyo zeentaba ezifana neShaanxi esenyakatho neHonghe, Yunnan, eChina. Ngenxa yomahluko omkhulu wobushushu phakathi kwemini nobusuku kunye nokufuma okufanelekileyo, i-clarysol kwezi ndawo zokuvelisa inobunyulu obuphezulu kunye nevumba elicocekileyo.
Kukho iindlela ezininzi eziphambili zokwenza i-sclareol:
1. Ukwenziwa kweekhemikhali
Ngokubanzi,i-sclareolisicatshulwa sisetyenziswa njengento ekrwada yokutsalwa kunye nokuhlanjululwa. Intsalela ye-sclareol emva kokuchithwa kweoli iyachithwa kwi-ethanol, kwaye i-sclareol iyancipha ngendlela yeenaliti ezimhlophe emva kokukhenkceza okuphantsi kobushushu, ukucoca, unyango lwekhabhoni olusebenzayo, ukuhlanjululwa kunye namanye amanyathelo. Emva kwe-centrifugal dehydration, i-vacuum drying, ukutyumza kunye nokuhlola, i-sclareol enomxholo ophezulu wotywala inokufumaneka.
2. I-Biosynthesis
Ukwakhiwa kwefektri yeseli yegwele yotywala: Kuphononongo, i-synthases ezimbini ze-TPS kunye ne-LPPs kwi-sage zaqala ukudityaniswa kwi-yeast gene, eyandisa ngokufanelekileyo imveliso ye-yeast.i-sclareol. Emva koko i-N-terminus ye-TPS-LPPS idibaniswe nenxalenye yeprotheni yokubopha i-maltose ukuqhubela phambili ukuphucula ukuzinza kwe-enzyme kunye nokwandisa isivuno kwakhona. Emva koko, iqela lophando lahlula yonke indlela ye-metabolic kwiimodyuli ezintathu: indlela ephakathi ye-metabolic yokubonelela nge-acetyl coenzyme A, indlela ye-isoprenoid biosynthesis kunye nemodyuli yokulawula ukuguqulwa kwenkqubo. Ngokubuyiselwa kunye nokususwa kwezinye iijini ezinxulumeneyo, i-chassis strain enokubonelela ngokufanelekileyo i-acetyl-CoA kunye ne-NADPH yakhiwa, kwaye isivuno se-sclareol saphuculwa ngakumbi ngokugqithiswa kofuzo oluthile. Ekugqibeleni, umphumo wemodyuli nganye kwi-synthesis ye-sclareol yahlaziywa ngeprofayili ye-metabolic yobunzima obunjineli, kwaye kwafunyaniswa ukuba iimodyuli ezintathu zinefuthe le-synergistic. I-Fed-batch fermentation yenziwa kwiiflasks ze-shake kunye ne-bioreactors, kwaye ekugqibeleni i-sclareol yadityaniswa ngokufanelekileyo kwi-Saccharomyces cerevisiae kusetyenziswa i-glucose njengento ekrwada, kunye nesivuno se-11.4 g/L.
●Yintoni naIingeneloKwe Sclareol ?
Uphononongo lwakutsha nje luveze imisebenzi yebhayoloji ene-multi-dimensional ye-sclareol, ngakumbi kwicandelo lezifo zenkqubo yemithambo-luvo:
1. Anti-ukudumba kunye neuroprotective:
Ivimbela ukusetyenziswa ngokugqithiseleyo kwe-microglia, inciphisa amanqanaba ezinto ezivuthayo ze-TNF-α kunye ne-IL-1β, ikhulula ukuphazamiseka kwentshukumo kwiigundane ze-Parkinson, kwaye ikhusela i-dopamine neurons;
Ukuphucula ukusebenza kwengqondo kwiimodeli zesifo se-Alzheimer. I-dose ye-50-200mg / (kg·d) inokuthintela ukusebenza kwe-astrocytes kwingqondo kunye nokunciphisa i-deposition ye-β-amyloid protein.
2. Umsebenzi wokulwa nomhlaza:
Ine-cytotoxicity eyomeleleyo kwimigca yeeseli zomhlaza ezifana ne-mouse leukemia (P-388) kunye ne-human epidermal carcinoma (KB), kwaye inqanda ukwanda kwethumba ngokubangela i-apoptosis.
3. I-antibacterial kunye ne-antioxidant:
Inoluhlu olubanzi lokuthintela ukukhula kwebhaktheriya, kunye nokusebenza kwayo kwe-antioxidant ngamaxesha angama-50 e-vitamin E, efanelekile kwiingubo zenxeba kunye neemveliso zokunakekelwa kwesikhumba ezichasayo.
●Yintoni naIsiceloOf Sclareol ?
1. Ishishini lencasa nevumba:
Njengowona mthombo wemveliso we-ambergris, ithatha indawo ye-ambergris yendalo evela kwiminenga esengozini yokuphela. Isixa esincinci sisetyenziswa ngokuthe ngqo kwiziqholo eziphezulu zokunika ivumba elihlala lihleli kwaye lineengqimba.
2. Uphando lwamachiza kunye nophuhliso:
I-Alzheimer's disease / Parkinson's disease drug: ii-capsules zomlomo okanye ii-injection ziye zangena kuphando lwangaphambili, zijolise ekuvimbeleni i-neuroinflammation;
Unyango lwe-anti-cancer adjuvant: ludityaniswe namachiza echemotherapy ukomeleza ukubulawa kweeseli zethumba.
3. Izithambiso kunye nokutya:
Iimveliso zokunakekelwa kwesikhumba ezichasayo: yongeza i-0.5% -2% ukuvimbela i-photoaging kunye nokunciphisa i-ultraviolet erythema;
Izilondolozo zendalo: ezisetyenziselwa ukutya okunamafutha ukwandisa ubomi beshelufu, kwaye zikhuselekile kuneemveliso zokwenziwa kweekhemikhali.
●ENTSHA Unikezelo lomgangatho ophezuluSclareolUmgubo
Ixesha lokuposa: Jul-18-2025
