●Yintoni i I-Minoxidil?
Kwingxelo yengozi yembali yonyango, i-minoxidil inokuthathwa njengenye yezona "zifunyenwe ngengozi". Xa yayiphuhliswa njengeyeza elichasayo kwiminyaka yoo-1960, umphumo wecala we-hypertrichosis obangelwa yiyo yaba yinto eguqukayo kunyango lokulahleka kweenwele. Emva kweminyaka ephantse ibe yi-60 yophuhliso, le khompawundi ifumene iifom ezininzi zedosi ezifana nezisombululo, amagwebu, kunye neejeli. Izinga elisebenzayo elipheleleyo le-5% ye-minoxidil ekuphatheni i-telogen effluvium idlula i-80%, ephinda iqinisekisa amandla ayo okuwela.
Igama lekhemikhali ye-minoxidil yi-6-(1-piperidinyl) -2,4-pyrimidinediamine-3-oxide, kunye ne-molecular formula ye-C₉H₁₅N₅O, indawo yokunyibilika ye-272-274℃, indawo yokubilisa ye-351.7℃, i-1.1. kwaye inyibilika ngokulula kwi-ethanol kunye nepropylene glycol.
●ZintoniIingeneloKwe I-Minoxidil ?
Ngokusekwe kuphando lwendlela yeemolekyuli, iminoxidil ibonisa iziphumo zebhayoloji ezinamacala amaninzi:
1. I-Vascular Dynamics
Yenza kusebenze i-ATP-sensitive potassium channels (KATP), ikhulula i-vascular smooth muscles, kwaye inyuse ukuhamba kwegazi kwe-scalp ngama-40% -60%.
Ukukhuthaza ukubonakaliswa kwe-VEGF, kwandisa ukuxinana kwemithambo yegazi emitsha ngamaxesha angama-2.3, kwaye kuphuculwe ukubonelelwa ngezondlo kwiifollicle zeenwele.
2. Ukulawulwa kwe-Hair Follicle Cycle
Yenza mfutshane inqanaba lokuphumla (ukusuka kwiintsuku ezili-100 ukuya kwiintsuku ezingama-40) kwaye wandise isigaba sokukhula sibe ngaphezulu kweentsuku ezingama-200.
I-Minoxidilinokusebenzisa indlela ye-Wnt / β-catenin, kwaye inyuse izinga lokunyuka kweeseli ze-hair papilla nge-75%.
3. Ukuphuculwa koBume beNdawo
Ivimbela umsebenzi we-5α-reductase, iyanciphisa i-DHT yoxinaniso nge-38%, kwaye ikhulula i-alopecia ye-androgenic.
Ukulawula izinto ezivuthayo ezifana ne-IL-6 kunye ne-TNF-α, kwaye iyanciphisa amanqaku okuvuvukala kwe-scalp nge-52%.
●ZintoniIsiceloOf I-Minoxidil?
I-Minoxidil igqobhoza imida yezalathisi zemveli:
1. Amayeza eNwele
I-Androgenetic alopecia: isisombululo se-5% siphatha i-AGA yamadoda, kwaye izinga lokugubungela iinwele landa ngama-47% kwiinyanga ezili-12.
I-Alopecia areata: Uphononongo lwaseJapan ngo-2025 lubonise ukuba ukusebenza kakuhle kwe-JAK inhibitors ezidityanisiweyo kunyuke ukusuka kuma-35% ukuya kuma-68% ngechiza elinye.
2. Ukuhlaziywa kolusu
Izilonda ezinyaweni zesifo seswekile: Ukusetyenziswa kwendawo kukhawulezisa ukuphiliswa kwenxeba kwaye kunciphise ixesha lokupholisa nge-30%.
Ukulungiswa kwescar: Inqanda ukubonakaliswa kwe-TGF-β1 kwaye kunciphisa ukuqina kwesiva nge-42%.
3. ULimo kunye noKhuseleko lokusiNgqongileyo
Ukulawulwa kokukhula kwezityalo: isisombululo se-0.1ppm siphatha irayisi, kwaye inani le-tillers landa nge-18%.
Ukulungiswa komhlaba: Ukusebenza kakuhle kwe-adsorption ye-cadmium yentsimbi enzima ifikelela kwi-89%, esetyenziselwa ukubuyisela i-ikholoji kwiindawo zemigodi.
●Amanyathelo okuzikhuselayeI-Minoxidil Ukusetyenziswa kwexesha elide
Izalathi zokubeka iliso: Qwalasela uxinzelelo lwegazi kunye nesantya sentliziyo, ngakumbi kwabo banezifo zentliziyo;
Amaqela aphikisanayo: Abasetyhini abakhulelweyo, abafazi abancancisayo, kunye nalabo abachasene nepropylene glycol abavunyelwe;
Ukukhethwa kwefom ye-dosage: I-5% yoxinaniso inconywa kumadoda, kwaye i-2% inokukhethwa kubasetyhini ukunciphisa imiphumo emibi;
Unyango oludibeneyo: Ukulahleka kweenwele ezinzima kunokudibaniswa ne-finasteride (kumadoda) okanye unyango lwe-laser oluphantsi kwamandla.
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●Newgreen Supply High Quality I-MinoxidilUmgubo
Ixesha lokuposa: Aug-20-2025
