●Yintoni iL-Citrulline?
I-L-Citrulline i-non-proteinogenic α-amino acid, ebizwa ngokuba yizazinzulu eziye zaqala ukuzihlukanisa ne-watermelon (i-Citrullus lanatus) ijusi ngo-1930. Igama layo lekhemikhali (S) -2-amino-5-ureidopentanoic acid, kunye ne-molecular formula ye-C₆H₁₃1 N₃₃ inombolo ye-CAS ₃ 7 ye-molecular ₆H₁₃1 ₃ ₃ 9 ye-molecular ₃9 CAS. 372-75-8237. Imveliso yanamhlanje yemizi-mveliso iyenzeka ikakhulu ngeendlela ezimbini:
Ukutsalwa kwendalo: ukwahluka kwizityalo ze-cucurbitaceae ezifana ne-vatala kunye ne-cucumber, kodwa ngokusebenza okuphantsi kunye neendleko eziphezulu;
I-Biosynthesis: i-catalytic generation kumjikelezo we-urea usebenzisa i-ornithine kunye ne-carbamoyl phosphate njenge-substrates, okanye ukuguqulwa kwe-oxidative ye-arginine phantsi kwesenzo se-nitric oxide synthase (NOS).
Iimpawu zomzimba kunye neekhemikhaliye L-Citrulline :
Iipropati kunye nokunyibilika: umgubo omhlophe wekristale, incasa emuncu kancinane; Inyibilika ngokulula emanzini (ukunyibilika 200g/L, 20℃), phantse ukunganyibiliki kwizinyibilikisi eziphilayo ezifana ne-ethanol kunye ne-ether;
Iimpawu ze-Optical: ukujikeleza okuthe ngqo + 24.5 ° ~ + 26.8 ° (c = 8, 6N HCl), eyona nto isalathiso esibalulekileyo sokuchongwa kobunyani;
Iziphene zokuzinza: ubuthathaka kukukhanya kunye nobushushu, indawo yokunyibilika yi-214-222 ℃ (iifom zekristale ezahlukeneyo), kulula ukubola ngaphezu kwe-100 ℃; kufuneka itywinwe kwaye igcinwe kude nokukhanya kunye nobushushu obuphantsi (0-5℃);
Imigangatho yokulawula umgangatho: iimveliso zodidi lwamayeza zifuna isinyithi esinzima ≤10ppm, umxholo wamanzi ≤0.30%, kunye nentsalela yokutshisa ≤0.10% (i-AJI92 standard).
●Yintoni naIingeneloKweL-Citrulline ?
Ixabiso eliphambili le-L-citrulline lilele ekukwazini ukuguqula kwi-arginine kunye nokukhulula i-nitric oxide (NO), ngaloo ndlela isebenze iziphumo ezininzi ze-physiological:
Ukukhuselwa kwentliziyo
Ukunciphisa uxinzelelo lwe-vascular nokuphucula ukuhamba kwegazi nge-NO-mediated vascular smooth muscle relaxation;
Uphononongo olwenziwa yiYunivesithi yaseTexas A&M e-United States yaqinisekisa ukuba indlela yayo ye-vasodilatory effect ifana ne "Viagra yendalo", enezinga lokuphucula i-40% ye-erectile dysfunction kwaye akukho miphumo emibi yeziyobisi.
I-Metabolism kunye noLawulo lwamajoni omzimba
Ukukhuthaza umjikelezo we-urea yesibindi, ukukhawulezisa imetabolism ye-ammonia, kunye nokunciphisa uxinzelelo lwegazi lwe-ammonia;
Ukwandisa umsebenzi we-macrophage kunye nokuphucula isakhono sokulwa neentsholongwane (ezifana nezinga lokucocwa kwentsholongwane yomkhuhlane linyuke ngama-35%).
Inzwa kunye nokusebenza kweMoto
Wela umqobo wegazi-ubuchopho ukunyusa amanqanaba e-NO kwingqondo kunye nokuphucula amandla okufumana ulwazi lwememori;
I-Neutralize iintlobo ze-oksijeni ezisebenzayo (ROS) ezenziwe ngokuzilolonga kunye nokwandisa ixesha lokunyamezela kwemisipha nge-22%.
●Yintoni naIsiceloOf L-Citrulline?
1. Ishishini lezempilo:
Imveliso yezondlo zezemidlalo: idibaniswe ne-branched-chain amino acids, i-concentration ye-ketone yegazi emva kokuzivocavoca igcinwe ngaphezu kwe-4mM, kwaye ixesha lokubuyisela imisipha lifinyezwa yi-30% (isabelo semarike yehlabathi kwi-2024 yi-45%);
Ukuphucula umsebenzi wesondo: i-citrulline inokukhuthaza i-vasodilation kunye nokuphucula ukungasebenzi kakuhle kwe-erectile
2. Ishishini lokutya:
I-preservative yendalo: inqanda ukwanda kwee-microorganisms kwimveliso yenyama yasemanzini, kwaye inani elipheleleyo le-colon ye-salmon efrijini liyancipha nge-90%;
Izongezo ezisebenzayo: "L-Citrulline + γ-aminobutyric acid" i-yogurt esebenzayo, i-synchronously ilawula uxinzelelo lwe-vascular kunye nokukhathazeka.
3. I-Biomedicine:
Unyango lwe-Alzheimer's disease: sebenzisa indlela ye-cAMP / PI3K-Akt, ukwandisa ukubonakaliswa kwe-brain-derived neurotrophic factor (BDNF), kunye nokuphucula ukufunda kunye nokukwazi ukukhumbula iigundane zemodeli nge-40%;
Inkqubo yokuhanjiswa kweGene: njenge-pDNA nanocarrier, ukusebenza kakuhle kosulelo kuphindwe kali-100 ngaphezulu kwe-liposomes, kwaye iyakungena kwiSigaba soku-I solingo lwezonyango lonyango lwethumba lobuchopho ngo-2025.
4. I-Cosmetic Innovation
Ukudibanisa kunye ne-polysaccharide moisturizers, ukuphumelela kokunyanga kwesikhumba esomileyo kungaphezulu kwe-80%;
Ivimbela ukuhanjiswa kweempawu ze-nerve kwi-pruritic dermatitis kunye nokulungisa umsebenzi womqobo we-stratum corneum.
●Newgreen Supply High QualityL-CitrullineUmgubo
Ixesha lokuposa: Jul-16-2025
